دورية أكاديمية
Intellectual functioning in relation to autism and ADHD symptomatology in children and adolescents with 22q11.2 deletion syndrome.
| العنوان: | Intellectual functioning in relation to autism and ADHD symptomatology in children and adolescents with 22q11.2 deletion syndrome. |
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| المؤلفون: | Hidding E; Department of Clinical Child and Adolescent Studies, Faculty of Social and Behavioural Sciences, Leiden University, Leiden, The Netherlands., Swaab H; Department of Clinical Child and Adolescent Studies, Faculty of Social and Behavioural Sciences and Leiden Institute of Brain and Cognition, Leiden University, Leiden, The Netherlands., de Sonneville LM; Department of Clinical Child and Adolescent Studies, Faculty of Social and Behavioural Sciences and Leiden Institute of Brain and Cognition, Leiden University, Leiden, The Netherlands., van Engeland H; Department of Psychiatry, Brain Center Rudolph Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands., Sijmens-Morcus ME; Department of Clinical Child and Adolescent Studies, Faculty of Social and Behavioural Sciences, Leiden University, Leiden, The Netherlands., Klaassen PW; Department of Pediatric Psychology, University Medical Centre Utrecht, Utrecht, The Netherlands., Duijff SN; Department of Psychiatry, Brain Center Rudolph Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands.; Department of Pediatric Psychology, University Medical Centre Utrecht, Utrecht, The Netherlands., Vorstman JA; Department of Psychiatry, Brain Center Rudolph Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands. |
| المصدر: | Journal of intellectual disability research : JIDR [J Intellect Disabil Res] 2015 Sep; Vol. 59 (9), pp. 803-15. Date of Electronic Publication: 2015 Feb 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Scientific Publications on behalf of the Royal Society for Mentally Handicapped Children and Adults Country of Publication: England NLM ID: 9206090 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2788 (Electronic) Linking ISSN: 09642633 NLM ISO Abbreviation: J Intellect Disabil Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, UK : Blackwell Scientific Publications on behalf of the Royal Society for Mentally Handicapped Children and Adults, 1992- |
| مواضيع طبية MeSH: | 22q11 Deletion Syndrome/*physiopathology , Attention Deficit Disorder with Hyperactivity/*physiopathology , Autism Spectrum Disorder/*physiopathology , Intelligence/*physiology, 22q11 Deletion Syndrome/complications ; Adolescent ; Attention Deficit Disorder with Hyperactivity/etiology ; Autism Spectrum Disorder/etiology ; Child ; Female ; Humans ; Male ; Severity of Illness Index ; Wechsler Scales |
| مستخلص: | Background: The 22q11.2 deletion syndrome (22q11DS; velo-cardio-facial syndrome) is associated with an increased risk of various disorders, including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). With this study, we aimed to investigate the relation between intellectual functioning and severity of ASD and ADHD symptomatology in 22q11DS. Method: A sample of 102 individuals (62 females) with 22q11DS aged 9 to 18.5 years were assessed using age appropriate Wechsler scales of intelligence as well as psychological and psychiatric assessment to evaluate the presence of ASD and ADHD symptomatology. Results: Intelligence profiles were characterised by lower scores on the factor perceptual organisation and higher scores on the factor processing speed, with on subtest level higher scores on digit span and lower scores on arithmetic and vocabulary as compared with the mean factor or subtest score respectively. No differences in intelligence profiles were found between subgroups with and without ASD and/or ADHD. Low scores on coding were associated with higher severity of ASD symptomatology, while lower scores on block design were associated with more severe ADHD symptomatology. Conclusions: On several sub-domains of intelligence, poorer performance was associated with higher severity of ASD and ADHD symptomatology. The impact of developmental disorders in 22q11DS can be traced in specific domains of intellectual functioning as well as in severity of symptomatology. (© 2015 MENCAP and International Association of the Scientific Study of Intellectual and Developmental Disabilities and John Wiley & Sons Ltd.) |
| فهرسة مساهمة: | Keywords: 22q11 deletion syndrome; ADHD; autism; intelligence; velo-cardio-facial syndrome |
| تواريخ الأحداث: | Date Created: 20150217 Date Completed: 20160601 Latest Revision: 20150821 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1111/jir.12187 |
| PMID: | 25683771 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1365-2788 |
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| DOI: | 10.1111/jir.12187 |