دورية أكاديمية
Determination of quinolones and fluoroquinolones, tetracyclines and sulfonamides in bovine, swine and poultry liver using LC-MS/MS.
| العنوان: | Determination of quinolones and fluoroquinolones, tetracyclines and sulfonamides in bovine, swine and poultry liver using LC-MS/MS. |
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| المؤلفون: | Martins MT; a Ministério da Agricultura , Pecuária e Abastecimento, Laboratório Nacional Agropecuário - LANAGRO/RS , Porto Alegre , RS , Brazil., Barreto F, Hoff RB, Jank L, Arsand JB, Feijó TC, Schapoval EE |
| المصدر: | Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment [Food Addit Contam Part A Chem Anal Control Expo Risk Assess] 2015; Vol. 32 (3), pp. 333-41. Date of Electronic Publication: 2015 Feb 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101485040 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-0057 (Electronic) Linking ISSN: 19440057 NLM ISO Abbreviation: Food Addit Contam Part A Chem Anal Control Expo Risk Assess Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Abingdon, Oxon ; Philadelphia, PA : Taylor & Francis, 2008- |
| مواضيع طبية MeSH: | Drug Residues/*analysis , Fluoroquinolones/*analysis , Liver/*chemistry , Quinolones/*analysis , Sulfonamides/*analysis , Tetracyclines/*analysis, Animals ; Anti-Bacterial Agents/analysis ; Cattle ; Chromatography, Liquid ; Poultry ; Swine ; Tandem Mass Spectrometry ; Veterinary Drugs/analysis |
| مستخلص: | Antibacterials are widely used in veterinary medicine. Residues of these drugs can remain in food of animal origin, including bovine liver. This paper describes a fast and simple analytical method for the determination of quinolones and fluoroquinolones, tetracyclines and sulfonamides in bovine liver samples. Deuterated enrofloxacin, sulfapyridine and demeclocycline were used as internal standards. The homogenised liver samples were extracted with acidified acetonitrile. Steps of non-solid-phase extraction (SPE) clean-up and concentration were used in the presented method. The final extracts were analysed by sensitive and selective detection of all components in a single run using LC-MS/MS. Acceptable recoveries between 66% and 110% were obtained. Good linearity (r(2)) above 0.96, considering three different days, for all drugs was achieved in concentrations ranging from 0.0 to 2.0 × the maximum residue limit (MRL). Intraday precision with coefficient of variation (CV%) (n = 6) lower than 14.7% and inter-day precision lower than 18.8% in agreement with European Commission Decision 2002/657/EC were obtained in concentrations ranging from 0.5 to 1.5 MRL. Accuracy was between 86% and 110%. Limits of detection and quantitation, as well as decision limit (CCα) and detection capability (CCβ), were also evaluated. |
| فهرسة مساهمة: | Keywords: antibacterials; bovine liver; food control; mass spectrometry; validation |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Fluoroquinolones) 0 (Quinolones) 0 (Sulfonamides) 0 (Tetracyclines) 0 (Veterinary Drugs) |
| تواريخ الأحداث: | Date Created: 20150217 Date Completed: 20160107 Latest Revision: 20150408 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1080/19440049.2015.1007091 |
| PMID: | 25686359 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1944-0057 |
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| DOI: | 10.1080/19440049.2015.1007091 |