دورية أكاديمية
أعرض في EDS

In-vivo imaging of grey and white matter neuroinflammation in Alzheimer's disease: a positron emission tomography study with a novel radioligand, [18F]-FEPPA.

التفاصيل البيبلوغرافية
العنوان: In-vivo imaging of grey and white matter neuroinflammation in Alzheimer's disease: a positron emission tomography study with a novel radioligand, [18F]-FEPPA.
المؤلفون: Suridjan I; Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada., Pollock BG; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada., Verhoeff NP; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.; Centre for Mental Health, Baycrest Health Sciences, Toronto, ON, Canada., Voineskos AN; Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada., Chow T; Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.; Centre for Mental Health, Baycrest Health Sciences, Toronto, ON, Canada.; Department of Medicine (Neurology), University of Toronto, Toronto, ON, Canada., Rusjan PM; Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada., Lobaugh NJ; Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Department of Medicine (Neurology), University of Toronto, Toronto, ON, Canada., Houle S; Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada., Mulsant BH; Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada., Mizrahi R; Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
المصدر: Molecular psychiatry [Mol Psychiatry] 2015 Dec; Vol. 20 (12), pp. 1579-87. Date of Electronic Publication: 2015 Feb 24.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Publication: 2000- : Houndmills, Basingstoke, UK : Nature Publishing Group Specialist Journals
Original Publication: Houndmills, Hampshire, UK ; New York, NY : Stockton Press, c1996-
مواضيع طبية MeSH: Alzheimer Disease/*pathology , Encephalitis/*pathology , Gray Matter/*pathology , White Matter/*pathology, Aged ; Aged, 80 and over ; Anilides ; Cognition Disorders/pathology ; Female ; Fluorine Radioisotopes ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Positron-Emission Tomography ; Pyridines ; Radioligand Assay
مستخلص: Our primary aim was to compare neuroinflammation in cognitively intact control subjects and patients with Alzheimer's disease (AD) by using positron emission tomography (PET) with translocator protein 18 kDa (TSPO)-specific radioligand [(18)F]-FEPPA. [(18)F]-FEPPA PET scans were acquired on a high-resolution research tomograph in 21 patients with AD (47- 81 years) and 21 control subjects (49-82 years). They were analyzed by using a 2-tissue compartment model with arterial plasma input function. Differences in neuroinflammation, indexed as [(18)F]-FEPPA binding were compared, adjusting for differences in binding affinity class as determined by a single polymorphism in the TSPO gene (rs6971). In grey matter areas, [(18)F]-FEPPA was significantly higher in AD compared with healthy control subjects. Large increases were seen in the hippocampus, prefrontal, temporal, parietal and occipital cortex (average Cohen's d= 0.89). Voxel-based analyses confirmed significant clusters of neuroinflammation in the frontal, temporal and parietal cortex in patients with AD. In white matter, [(18)F]-FEPPA binding was elevated in the posterior limb of the internal capsule, and the cingulum bundle. Higher neuroinflammation in the parietal cortex (r= -0.7, P= 0.005), and posterior limb of the internal capsule (r= -0.8, P=0.001) was associated with poorer visuospatial function. In addition, a higher [(18)F]-FEPPA binding in the posterior limb of the internal capsule was associated with a greater impairment in language ability (r= -0.7, P=0.004). Elevated neuroinflammation can be detected in AD patients throughout the brain grey and white matter by using [(18)F]-FEPPA PET. Our results also suggest that neuroinflammation is associated with some cognitive deficits.
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معلومات مُعتمدة: R01 MH100043 United States MH NIMH NIH HHS
المشرفين على المادة: 0 (Anilides)
0 (Fluorine Radioisotopes)
0 (N-(2-((N-(4-phenoxypyridin-3-yl)acetamido)methyl)phenoxy)ethyl fluoride)
0 (Pyridines)
تواريخ الأحداث: Date Created: 20150225 Date Completed: 20160829 Latest Revision: 20210409
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8026116
DOI: 10.1038/mp.2015.1
PMID: 25707397
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-5578
DOI:10.1038/mp.2015.1