دورية أكاديمية

HPV in oropharyngeal cancer: the basics to know in clinical practice.

التفاصيل البيبلوغرافية
العنوان: HPV in oropharyngeal cancer: the basics to know in clinical practice.
المؤلفون: Elrefaey S; Division of Otolaryngology Head and Neck Surgery, European Institute of Oncology, Milano, Italy; ; Department of Otolaryngology, Head and Neck Surgery, Alexandria University, Alexandria, Egypt;, Massaro MA; Division of Otolaryngology Head and Neck Surgery, European Institute of Oncology, Milano, Italy;, Chiocca S; Department of Experimental Oncology, IFOM-IEO Campus, European Institute of Oncology, Milano, Italy., Chiesa F; Division of Otolaryngology Head and Neck Surgery, European Institute of Oncology, Milano, Italy;, Ansarin M; Division of Otolaryngology Head and Neck Surgery, European Institute of Oncology, Milano, Italy;
المصدر: Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale [Acta Otorhinolaryngol Ital] 2014 Oct; Vol. 34 (5), pp. 299-309.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Pacini editore Country of Publication: Italy NLM ID: 8213019 Publication Model: Print Cited Medium: Internet ISSN: 1827-675X (Electronic) Linking ISSN: 0392100X NLM ISO Abbreviation: Acta Otorhinolaryngol Ital Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Pisa : Pacini editore, 1981-
مواضيع طبية MeSH: Carcinoma, Squamous Cell/*virology , Oropharyngeal Neoplasms/*virology , Papillomavirus Infections/*complications, Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/therapy ; Humans ; Oropharyngeal Neoplasms/diagnosis ; Oropharyngeal Neoplasms/therapy ; Papillomavirus Infections/diagnosis ; Papillomavirus Infections/therapy ; Papillomavirus Vaccines
مستخلص: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) is rising in contrast to the decreasing incidence of carcinomas in other subsites of the head and neck, in spite of the reduced prevalence of smoking. Human papilloma virus (HPV) infection, and in particular type 16 (HPV-16), is now recognized as a significant player in the onset of HPV positive OPSCC, with different epidemiological, clinical, anatomical, radiological, behavioural, biological and prognostic characteristics from HPV negative OPSCC. Indeed, the only subsite in the head and neck with a demonstrated aetiological viral link is, at present, the oropharynx. These observations lead to questions regarding management choices for patients based on tumour HPV status with important consequences on treatment, and on the role of vaccines and targeted therapy over the upcoming years.
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فهرسة مساهمة: Keywords: Clinical Trial; Head and Neck cancer; Human Papillomavirus; Oropharyngeal cancer; Prevention; Prognosis; Squamous Cell Carcinoma; Treatment; Vaccination
Local Abstract: [Publisher, Italian] L'incidenza del carcinoma spinocellulare dell'orofaringe (OPSCC) è in aumento in contrasto con la diminuzione dell'incidenza di carcinomi in altre sedi del distretto cervico-facciale, nonostante la ridotta prevalenza del fumo. L'infezione da Papilloma Virus Umano (HPV), in particolare di tipo 16 (HPV 16), è ora riconosciuto come un importante fattore nell'insorgenza di HPV OPSCC positivo, con diverse caratteristiche radiologiche, epidemiologiche, cliniche, anatomiche, biologiche e prognostiche rispetto all'HPV OPSCC negativo. In effetti l'unica sede del distretto cervico-facciale con un collegamento virale eziologico dimostrato è, attualmente, l'orofaringe. Queste osservazioni portano a domande riguardanti le scelte di gestione per i pazienti in base allo stato del tumore HPV con importanti conseguenze sul trattamento e sul ruolo dei vaccini e terapia mirata per i prossimi anni.
المشرفين على المادة: 0 (Papillomavirus Vaccines)
تواريخ الأحداث: Date Created: 20150225 Date Completed: 20161215 Latest Revision: 20220408
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4299160
PMID: 25709145
قاعدة البيانات: MEDLINE