دورية أكاديمية
Bioactivity and chemical composition of the essential oil from the leaves of Guatteria australis A.St.-Hil.
| العنوان: | Bioactivity and chemical composition of the essential oil from the leaves of Guatteria australis A.St.-Hil. |
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| المؤلفون: | Siqueira CA; a Departamento de Biologia Vegetal , Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP) , 13083-970 Campinas , SP , Brazil., Serain AF, Pascoal AC, Andreazza NL, de Lourenço CC, Ruiz AL, de Carvalho JE, de Souza AC, Mesquita JT, Tempone AG, Salvador MJ |
| المصدر: | Natural product research [Nat Prod Res] 2015; Vol. 29 (20), pp. 1966-9. Date of Electronic Publication: 2015 Feb 24. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*chemistry , Antineoplastic Agents, Phytogenic/*chemistry , Antiprotozoal Agents/*chemistry , Guatteria/*chemistry , Oils, Volatile/*chemistry , Plant Oils/*chemistry, Anti-Bacterial Agents/isolation & purification ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antioxidants/chemistry ; Antioxidants/isolation & purification ; Antiprotozoal Agents/isolation & purification ; HT29 Cells ; Humans ; Plant Leaves/chemistry ; Polycyclic Sesquiterpenes ; Sesquiterpenes/chemistry ; Sesquiterpenes/isolation & purification ; Sesquiterpenes, Germacrane/chemistry ; Sesquiterpenes, Germacrane/isolation & purification |
| مستخلص: | Essential oil from the leaves of Guatteria australis was obtained by hydrodistillation, analyzed by Gas Chromatography coupled to Mass Spectromery (GC-MS) and their antiproliferative, antileishmanial, antibacterial, antifungal and antioxidant activities were also evaluated. Twenty-three compounds were identified among which germacrene B (50.66%), germacrene D (22.22%) and (E)-caryophyllene (8.99%) were the main compounds. The highest antiproliferative activity was observed against NCI-ADR/RES (TGI = 31.08 μg/ml) and HT-29 (TGI = 32.81 μg/ml) cell lines. It also showed good antileishmanial activity against Leishmania infantum (IC50 = 30.71 μg/ml). On the other hand, the oil exhibited a small effect against Staphylococcus aureus ATCC 6538, S. aureus ATCC 14458 and Escherichia coli ATCC 10799 (MIC = 250 μg/ml), as well as small antioxidant activity (457 μmol TE/g) assessed through ORACFL assay. These results represent the first report regarding chemical composition and bioactivity of G. australis essential oil. |
| فهرسة مساهمة: | Keywords: Annonaceae; Guatteria australis; bioactivity; essential oil |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Antineoplastic Agents, Phytogenic) 0 (Antioxidants) 0 (Antiprotozoal Agents) 0 (Oils, Volatile) 0 (Plant Oils) 0 (Polycyclic Sesquiterpenes) 0 (Sesquiterpenes) 0 (Sesquiterpenes, Germacrane) BHW853AU9H (caryophyllene) V2I9ATG34E (germacrene D) |
| تواريخ الأحداث: | Date Created: 20150225 Date Completed: 20151208 Latest Revision: 20191210 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/14786419.2015.1015017 |
| PMID: | 25710362 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1478-6427 |
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| DOI: | 10.1080/14786419.2015.1015017 |