دورية أكاديمية
Subconjunctival and topical application of recombinant tissue plasminogen activator in rabbits.
| العنوان: | Subconjunctival and topical application of recombinant tissue plasminogen activator in rabbits. |
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| المؤلفون: | Reggi JR; Department of Ophthalmology, Santa Casa de São Paulo, São Paulo, SP, Brazil., Hida RY; Department of Ophthalmology, Santa Casa de São Paulo, São Paulo, SP, Brazil., Hida MM; Department of Ophthalmology, Universidade Estadual Paulista 'Júlio de Mesquita Filho', Botucatu, SP, Brazil., Nishiwaki-Dantas MC; Department of Ophthalmology, Santa Casa de São Paulo, São Paulo, SP, Brazil., Suzuki H; Department of Ophthalmology, University of São Paulo, São Paulo, SP, Brazil. |
| المصدر: | Arquivos brasileiros de oftalmologia [Arq Bras Oftalmol] 2015 Jan-Feb; Vol. 78 (1), pp. 6-9. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Conselho Brasileiro de Oftalmologia Country of Publication: Brazil NLM ID: 0400645 Publication Model: Print Cited Medium: Internet ISSN: 1678-2925 (Electronic) Linking ISSN: 00042749 NLM ISO Abbreviation: Arq Bras Oftalmol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: São Paulo : Conselho Brasileiro de Oftalmologia Original Publication: São Paulo. |
| مواضيع طبية MeSH: | Anterior Chamber/*chemistry , Aqueous Humor/*chemistry , Fibrin Fibrinogen Degradation Products/*analysis , Tissue Plasminogen Activator/*pharmacology, Administration, Topical ; Animals ; Double-Blind Method ; Injections, Intraocular/methods ; Latex Fixation Tests ; Male ; Models, Animal ; Paracentesis ; Prospective Studies ; Rabbits ; Random Allocation ; Recombinant Proteins/pharmacology ; Tissue Plasminogen Activator/administration & dosage |
| مستخلص: | Purpose: To quantify fibrin degradation products after topical and subconjunctival administration of recombinant tissue plasminogen activator in rabbits. Methods: Fibrin formation was induced in the anterior chamber in 25 rabbits. Subsequently, five rabbits received an injection of r-TPA (positive control) in the anterior chamber, another 10 received a subconjunctival injection of r-TPA, and the remaining 10 received instillations of topical r-TPA. Afterwards, samples of aqueous humor were collected and semi-quantitative analysis of fibrin degradation products (FDP) was performed. Results: No statistical differences were noted between the treatment and control groups at any time point. Fibrin degradation products semi-quantification showed statistical improvement in the control group and the subconjunctival group. Conclusion: Fibrin degradation products were observed in the anterior chamber after subconjunctival administration of r-TPA. However, it was probably not sufficient to cause fibrin degradation. Topical r-TPA did not effectively absorb anterior chamber fibrin. |
| المشرفين على المادة: | 0 (Fibrin Fibrinogen Degradation Products) 0 (Recombinant Proteins) EC 3.4.21.68 (Tissue Plasminogen Activator) |
| تواريخ الأحداث: | Date Created: 20150226 Date Completed: 20150709 Latest Revision: 20150226 |
| رمز التحديث: | 20221213 |
| DOI: | 10.5935/0004-2749.20150003 |
| PMID: | 25714529 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1678-2925 |
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| DOI: | 10.5935/0004-2749.20150003 |