دورية أكاديمية
[Mutagenic activation and carcinogenicity of aminoazo dyes of ortho-aminoazotoluene and 3'-methyl-4-dimethylaminoazobenzene in experiments on suckling mice].
| العنوان: | [Mutagenic activation and carcinogenicity of aminoazo dyes of ortho-aminoazotoluene and 3'-methyl-4-dimethylaminoazobenzene in experiments on suckling mice]. |
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| المؤلفون: | Kaledin VI, Il'nitskaia SI, Ovchinnikova LP, Popova NA, Bogdanova LA, Morozkova TS |
| المصدر: | Biofizika [Biofizika] 2014 May-Jun; Vol. 59 (3), pp. 527-32. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Izdatelstvo Nauka Country of Publication: Russia (Federation) NLM ID: 0372666 Publication Model: Print Cited Medium: Print ISSN: 0006-3029 (Print) Linking ISSN: 00063029 NLM ISO Abbreviation: Biofizika Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva : Izdatelstvo Nauka |
| مواضيع طبية MeSH: | Liver Neoplasms, Experimental*/chemically induced , Liver Neoplasms, Experimental*/enzymology , Liver Neoplasms, Experimental*/genetics , Liver Neoplasms, Experimental*/pathology, Carcinogens/*toxicity , Coloring Agents/*toxicity , Methyldimethylaminoazobenzene/*toxicity , Mutagens/*toxicity , o-Aminoazotoluene/*toxicity, Animals ; Carcinogens/pharmacology ; Coloring Agents/pharmacology ; Liver/enzymology ; Liver/pathology ; Methyldimethylaminoazobenzene/pharmacology ; Mice ; Mice, Inbred CBA ; Mice, Inbred ICR ; Mutagens/pharmacology ; Rats ; Salmonella typhimurium/genetics ; Salmonella typhimurium/metabolism ; o-Aminoazotoluene/pharmacology |
| مستخلص: | It is found that after administration of 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB,) which was hepatocarcinogenic to rats, in suckling mice, the number of neoplastic lesions in the liver of mice was 3 times higher than after analogous administration of equimolar dose of ortho-aminoazotoluene (OAT)). However, in the Ames test (TA-98 strain of Salmonella typhimurium) with activation by hepatic enzymes (S-9 fraction) of both intact and Aroclor-1254-induced mice and rats OAT contributed by an order of magnitude to revertant colonies compared to 3'-Me-DAB. In vivo inhibition of sulfotransferase activity, the enzyme which catalyzes the final stage of the mutagenic activation of aminoazo dyes, had no effect on carcinogenicity of 3'-Me-DAB but more than 4 times elevated that of OAT. It was concluded that the mechanism of carcinogenic action of aminoazo dyes studied is not genotoxic and that the carcinogenic potential of OAT is lost in the process of mutagenic activation. |
| المشرفين على المادة: | 0 (Carcinogens) 0 (Coloring Agents) 0 (Mutagens) 55-80-1 (Methyldimethylaminoazobenzene) QHZ900P7ZA (o-Aminoazotoluene) |
| تواريخ الأحداث: | Date Created: 20150227 Date Completed: 20150331 Latest Revision: 20150226 |
| رمز التحديث: | 20221213 |
| PMID: | 25715596 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0006-3029 |
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