دورية أكاديمية
أعرض في EDS

[Subarachnoid meloxicam does not inhibit the mechanical hypernociception on carrageenan test in rats].

التفاصيل البيبلوغرافية
العنوان: [Subarachnoid meloxicam does not inhibit the mechanical hypernociception on carrageenan test in rats].
عنوان ترانسليتريتد: Meloxicam subaracnoide não inibe a hipernocicepção mecânica no teste da carragenina em ratos.
المؤلفون: Moura LF; Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil. Electronic address: lanucha_moura@terra.com.br., Vidor SB; Programa de Pós-Graduação em Ciências Veterinárias, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil., Trindade AB; Programa de Pós-Graduação em Ciências Veterinárias, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil., Mörschbächer PD; Programa de Pós-Graduação em Ciências Veterinárias, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil., Oleskovicz N; Universidade do Estado de Santa Catarina, Florianópolis, SC, Brasil., Contesini EA; Faculdade de Veterinária da Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil.
المصدر: Revista brasileira de anestesiologia [Rev Bras Anestesiol] 2015 Mar-Apr; Vol. 65 (2), pp. 124-9. Date of Electronic Publication: 2014 Sep 26.
نوع المنشور: English Abstract; Journal Article
اللغة: Portuguese
بيانات الدورية: Publisher: Elsevier Editora Ltda. em nome de Sociedade Brasileira de Anestesiologia Country of Publication: Brazil NLM ID: 0401316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1806-907X (Electronic) Linking ISSN: 00347094 NLM ISO Abbreviation: Rev Bras Anestesiol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: [Rio de Janeiro, Brazil] : Elsevier Editora Ltda. em nome de Sociedade Brasileira de Anestesiologia
Original Publication: Rio de Janeiro : Sociedade Brasileira de Anestesiologia
مستخلص: Background and Objective: Evaluate the antinociceptive effects of subarachnoid meloxicam on the mechanical hypernociception induced by carrageenan in rats.
Methods: Randomized controlled trial. Eighteen adult male Wistar rats underwent a cannula implantation into the subarachnoid space and were randomly divided into two groups: Group I (GI) received saline solution 5μL, while Group II (GII) received meloxicam 30mg. The mechanical hypernociception was induced by intraplantar injection of carrageenan and evaluated using a digital analgesymeter every 30minutes during a 4 hour period. The results were recorded as the Δ withdrawal threshold (in g), calculated by subtracting the measurement value after
Results: The Δ withdrawal threshold mean values were lower in the group of patients treated with meloxicam over all time points between 45 and 165minutes, however, there was no statistical significance, (p=0.835) for this difference.
Conclusion: Subarachnoid meloxicam at a dose of 30μg.animal(-1) did not suppress the mechanical hypernociception in a model of inflammatory pain induced by intraplantar administration of carrageenan in rats. The data suggest that other dosages should be investigated the drug effect is discarded.
(Copyright © 2014 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.)
فهرسة مساهمة: Keywords: AINE; Carrageenan; Carragenina; Dor; Medula espinhal; NSAIDs; Pain; Spinal cord
تواريخ الأحداث: Date Created: 20150306 Date Completed: 20150305 Latest Revision: 20150305
رمز التحديث: 20231215
DOI: 10.1016/j.bjan.2013.10.018
PMID: 25740279
قاعدة البيانات: MEDLINE
الوصف
تدمد:1806-907X
DOI:10.1016/j.bjan.2013.10.018