دورية أكاديمية
[Successful treatment with rituximab in a patient with splenic marginal zone B-cell lymphoma accompanied by cold agglutinin disease].
| العنوان: | [Successful treatment with rituximab in a patient with splenic marginal zone B-cell lymphoma accompanied by cold agglutinin disease]. |
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| المؤلفون: | Yasuyama M; Department of Medicine, Tokyo Women's Medical University, Medical Center East; Toshima Central Hospital., Kawauchi K, Otsuka K, Tamura H, Fujibayashi M |
| المصدر: | Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics [Nihon Ronen Igakkai Zasshi] 2014; Vol. 51 (6), pp. 569-75. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | Japanese |
| بيانات الدورية: | Publisher: Japan Geriatrics Society Country of Publication: Japan NLM ID: 7507332 Publication Model: Print Cited Medium: Internet ISSN: 0300-9173 (Print) Linking ISSN: 03009173 NLM ISO Abbreviation: Nihon Ronen Igakkai Zasshi Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Tokyo : Japan Geriatrics Society |
| مواضيع طبية MeSH: | Anemia, Hemolytic, Autoimmune/*etiology , Antineoplastic Agents/*therapeutic use , Lymphoma, B-Cell, Marginal Zone/*drug therapy , Rituximab/*therapeutic use , Splenic Neoplasms/*drug therapy, Aged, 80 and over ; Humans ; Lymphoma, B-Cell, Marginal Zone/complications ; Male |
| مستخلص: | An 81-year-old man was admitted to our hospital due to dyspnea in July 2008. A physical examination revealed marked splenomegaly, and the results of laboratory tests were as follows: hemoglobin (Hb)=7.0 g/dL, Ret=6.4%, WBC=24,100/μL (Ly: 20,003/μL), indirect bilirubin=3.6 mg/dL, LDH=232 IU/L. The cold agglutinin titer was 1 : 8,192, and a direct antiglobulin test was positive. A PET scan showed abnormal accumulation in the spleen and bone marrow. A bone marrow aspirate examination and biopsy demonstrated diffuse involvement of abnormal lymphocytes that were found to be positive for CD20 and negative for CD5, CD10, and cyclin D1. The immunoglobulin genes were clonally rearranged. Based on these findings, splenic marginal zone B-cell lymphoma (SMZL) associated with cold agglutinin disease (CAD) was diagnosed. Because the patient refused splenectomy, he was treated with four cycles of rituximab therapy (375 mg/kg, once a week). The Hb level and lymphocyte count subsequently normalized and the splenomegaly resolved. One year later, he relapsed and was again treated with rituximab therapy with complete remission. CAD accompanied by SMZL is very rare. Rituximab may be chosen as an alternative and effective therapeutic option in patients with SMZL-particularly those with autoimmune hemolytic anemia. |
| المشرفين على المادة: | 0 (Antineoplastic Agents) 4F4X42SYQ6 (Rituximab) |
| تواريخ الأحداث: | Date Created: 20150310 Date Completed: 20161006 Latest Revision: 20161230 |
| رمز التحديث: | 20221213 |
| DOI: | 10.3143/geriatrics.51.569 |
| PMID: | 25749330 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0300-9173 |
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| DOI: | 10.3143/geriatrics.51.569 |