دورية أكاديمية
Photodynamic antimicrobial effects of bis-indole alkaloid indigo from Indigofera truxillensis Kunth (Leguminosae).
| العنوان: | Photodynamic antimicrobial effects of bis-indole alkaloid indigo from Indigofera truxillensis Kunth (Leguminosae). |
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| المؤلفون: | Andreazza NL; Instituto de Biologia, Departamento de Biologia Vegetal, PPG BTPB e PPG BV, Universidade Estadual de Campinas (UNICAMP), 13083-970, Campinas, SP, Brazil, nathilu@gmail.com., de Lourenço CC, Stefanello MÉ, Atvars TD, Salvador MJ |
| المصدر: | Lasers in medical science [Lasers Med Sci] 2015 May; Vol. 30 (4), pp. 1315-24. Date of Electronic Publication: 2015 Mar 13. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: England NLM ID: 8611515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-604X (Electronic) Linking ISSN: 02688921 NLM ISO Abbreviation: Lasers Med Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Springer Original Publication: London : Baillière Tindall, c1986- |
| مواضيع طبية MeSH: | Photochemotherapy*, Anti-Bacterial Agents/*pharmacology , Indigo Carmine/*pharmacology , Photosensitizing Agents/*pharmacology, Anti-Bacterial Agents/chemistry ; Candida/drug effects ; Escherichia coli/drug effects ; Indigofera/chemistry ; Lasers, Semiconductor ; Microbial Sensitivity Tests ; Photosensitizing Agents/chemistry ; Proteus vulgaris/drug effects ; Singlet Oxygen/chemistry ; Staphylococcus aureus/drug effects ; Staphylococcus epidermidis/drug effects |
| مستخلص: | Multidrug-resistant microbial infections represent an exponentially growing problem affecting communities worldwide. Photodynamic therapy is a promising treatment based on the combination of light, oxygen, and a photosensitizer that leads to reactive oxygen species production, such as superoxide (type I mechanism) and singlet oxygen (type II mechanism) that cause massive oxidative damage and consequently the host cell death. Indigofera genus has gained considerable interest due its mutagenic, cytotoxic, and genotoxic activity. Therefore, this study was undertaken to investigate the effect of crude extracts, alkaloidal fraction, and isolated substance derived from Indigofera truxillensis in photodynamic antimicrobial chemotherapy on the viability of bacteria and yeast and evaluation of mechanisms involved. Our results showed that all samples resulted in microbial photoactivation in subinhibitory concentration, with indigo alkaloid presenting a predominant photodynamic action through type I mechanism. The use of CaCl2 and MgCl2 as cell permeabilizing additives also increased gram-negative bacteria susceptibility to indigo. |
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| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Photosensitizing Agents) 17778-80-2 (Singlet Oxygen) D3741U8K7L (Indigo Carmine) |
| تواريخ الأحداث: | Date Created: 20150313 Date Completed: 20151230 Latest Revision: 20181202 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s10103-015-1735-4 |
| PMID: | 25764449 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1435-604X |
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| DOI: | 10.1007/s10103-015-1735-4 |