دورية أكاديمية
أعرض في EDS

Renoprotective Effects of Vitex megapotamica (Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet.

التفاصيل البيبلوغرافية
العنوان: Renoprotective Effects of Vitex megapotamica (Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet.
المؤلفون: Araújo Vde O; Instituto de Ciências Biológicas, Médicas e da Saúde, Universidade Paranaense, P.O. Box 224, 87.502-210 Umuarama, PR, Brazil., Gasparotto FM; Laboratório de Farmacologia Cardiovascular, Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Rodovia Dourados, Itahum, Km 12, P.O. Box 533, 79.804-970 Dourados, MS, Brazil., Pires VA; Instituto de Ciências Biológicas, Médicas e da Saúde, Universidade Paranaense, P.O. Box 224, 87.502-210 Umuarama, PR, Brazil., Maciel AA; Instituto de Ciências Biológicas, Médicas e da Saúde, Universidade Paranaense, P.O. Box 224, 87.502-210 Umuarama, PR, Brazil., Ortmann CF; Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, Rua Roberto Sampaio Gonzaga, 88.040-380 Florianópolis, SC, Brazil., Cardozo Junior EL; Instituto de Ciências Biológicas, Médicas e da Saúde, Universidade Paranaense, P.O. Box 224, 87.502-210 Umuarama, PR, Brazil., Lourenço EL; Instituto de Ciências Biológicas, Médicas e da Saúde, Universidade Paranaense, P.O. Box 224, 87.502-210 Umuarama, PR, Brazil., Gasparotto Junior A; Laboratório de Farmacologia Cardiovascular, Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Rodovia Dourados, Itahum, Km 12, P.O. Box 533, 79.804-970 Dourados, MS, Brazil.
المصدر: Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2015; Vol. 2015, pp. 475380. Date of Electronic Publication: 2015 Feb 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub Country of Publication: United States NLM ID: 101215021 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1741-427X (Print) Linking ISSN: 1741427X NLM ISO Abbreviation: Evid Based Complement Alternat Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2011- : New York, NY : Hindawi Pub.
Original Publication: Oxford, UK : Oxford University Press, c2004-
مستخلص: Although Vitex megapotamica (Spreng.) Moldenke is used in Brazilian folk medicine as hypolipidemic drug no study has been conducted to evaluate the effects of this species in an experimental model of atherosclerosis. So, the aim of this study was to evaluate the possible renoprotective activity of methanolic extract obtained from Vitex megapotamica (MEVM) using C57BL/6 LDLr-null mice submitted to high fat diet (HFD). MEVM was orally administered at doses of 30, 100, and 300 mg/kg, for three weeks, starting from the 2nd week of HFD. Systolic blood pressure (SBP) and diuretic activity were measured weekly. At the end of experiments the serum lipids, atherogenic index serum (AIS), oxidative stress, and markers of renal function were determined. HFD induced a significant increase in the systolic blood pressure, dyslipidemia, increase in AIS, and lipid peroxidation accompanied by an important reduction in renal function. Treatment with MEVM was able to prevent increase in SBP, total cholesterol, triglycerides, AIS, urea, and creatinine levels in LDLr-null mice. These effects were accompanied by a significant reduction in oxidative stress and renal injury. The data reported here support the potential of Vitex megapotamica as candidate to be an herbal medicine used in cardiovascular or renal diseases.
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تواريخ الأحداث: Date Created: 20150320 Date Completed: 20150319 Latest Revision: 20201001
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4350963
DOI: 10.1155/2015/475380
PMID: 25788962
قاعدة البيانات: MEDLINE
الوصف
تدمد:1741-427X
DOI:10.1155/2015/475380