دورية أكاديمية
أعرض في EDS

Mechanisms involved in the anti-inflammatory action of a polysulfated fraction from Gracilaria cornea in rats.

التفاصيل البيبلوغرافية
العنوان: Mechanisms involved in the anti-inflammatory action of a polysulfated fraction from Gracilaria cornea in rats.
المؤلفون: Coura CO; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil., Souza RB; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil., Rodrigues JA; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil., Vanderlei Ede S; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil., de Araújo IW; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil., Ribeiro NA; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil., Frota AF; Faculty of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil., Ribeiro KA; Faculty of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil., Chaves HV; Faculty of Dentistry, Federal University of Ceará, Sobral, Ceará, Brazil., Pereira KM; Faculty of Dentistry, Federal University of Ceará, Sobral, Ceará, Brazil., da Cunha RM; Biotechnology Nucleus of Sobral, Sobral, Ceará, Brazil., Bezerra MM; Faculty of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil., Benevides NM; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
المصدر: PloS one [PLoS One] 2015 Mar 25; Vol. 10 (3), pp. e0119319. Date of Electronic Publication: 2015 Mar 25 (Print Publication: 2015).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Gracilaria*, Anti-Inflammatory Agents/*therapeutic use , Edema/*drug therapy , Plant Extracts/*therapeutic use, Animals ; Carrageenan ; Cyclooxygenase 2/metabolism ; Edema/chemically induced ; Interleukin-1beta/metabolism ; Phytotherapy ; Rats ; Rats, Wistar ; Tumor Necrosis Factor-alpha/metabolism
مستخلص: The anti-inflammatory mechanisms of the sulfated polysaccharidic fraction obtained from red marine alga Gracilaria cornea (Gc-FI) were investigated using a paw edema model induced in rats by different inflammatory agents (carrageenan, dextran, serotonin, bradykinin, compound 48/80 or L-arginine). Gc-FI at the doses of 3, 9 or 27 mg/kg, subcutaneously--s.c., significantly inhibited rat paw edema induced by carrageenan and dextran, as confirmed by myeloperoxidase and Evans' blue assessments, respectively. Gc-FI (9 mg/kg, s.c.) inhibited rat paw edema induced by histamine, compound 48/80 and L-arginine. Additionally, Gc-FI (9 mg/kg, s.c.) inhibited Cg-induced edema in animals with intact mast cells but did not inhibit that with degranulated mast cells by compound 48/80, revealing a protective role on mast cell membranes. Gc-FI down-regulated the IL-1β, TNF-α and COX-2 mRNA and protein levels compared with those of the carrageenan group, based on qRT-PCR and immunohistochemistry analyses. After inhibition with ZnPP IX, a specific heme oxygenase-1 (HO-1) inhibitor, the anti-inflammatory effect of Gc-FI was not observed in Cg-induced paw edema, suggesting that the anti-inflammatory effect of Gc-FI is, in part, dependent on the integrity of the HO-1 pathway. Gc-FI can target a combination of multiple points involved in inflammatory phenomena.
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المشرفين على المادة: 0 (Anti-Inflammatory Agents)
0 (Interleukin-1beta)
0 (Plant Extracts)
0 (Tumor Necrosis Factor-alpha)
9000-07-1 (Carrageenan)
EC 1.14.99.1 (Cyclooxygenase 2)
تواريخ الأحداث: Date Created: 20150326 Date Completed: 20160226 Latest Revision: 20240326
رمز التحديث: 20240326
مُعرف محوري في PubMed: PMC4373681
DOI: 10.1371/journal.pone.0119319
PMID: 25807556
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0119319