دورية أكاديمية
أعرض في EDS

Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline.

التفاصيل البيبلوغرافية
العنوان: Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline.
المؤلفون: Cho KO; 1] Department of Molecular Biology and Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center, Dallas, Texas 75390, USA [2] Department of Pharmacology, School of Medicine, The Catholic University of Korea, Seoul 137-701, South Korea., Lybrand ZR; Department of Molecular Biology and Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center, Dallas, Texas 75390, USA., Ito N; 1] Department of Psychiatry, UT Southwestern Medical Center, Dallas, Texas 75390, USA [2] Department of Clinical Research, Oriental Medicine Research Center, Kitasato University, Tokyo 108-8641, Japan., Brulet R; Department of Molecular Biology and Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center, Dallas, Texas 75390, USA., Tafacory F; Department of Molecular Biology and Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center, Dallas, Texas 75390, USA., Zhang L; Department of Molecular Biology and Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center, Dallas, Texas 75390, USA., Good L; Department of Neurology &Neurotherapeutics, UT Southwestern Medical Center, Dallas, Texas 75390, USA., Ure K; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital and Baylor College of Medicine, Houston, Texas 77030, USA., Kernie SG; Department of Pediatrics, Columbia University, New York, New York 10027, USA., Birnbaum SG; Department of Psychiatry, UT Southwestern Medical Center, Dallas, Texas 75390, USA., Scharfman HE; The Nathan Kline Institute for Psychiatric Research and NYU Langone Medical Center, Orangeburg, New York 10962, USA., Eisch AJ; Department of Psychiatry, UT Southwestern Medical Center, Dallas, Texas 75390, USA., Hsieh J; Department of Molecular Biology and Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center, Dallas, Texas 75390, USA.
المصدر: Nature communications [Nat Commun] 2015 Mar 26; Vol. 6, pp. 6606. Date of Electronic Publication: 2015 Mar 26.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Cognition Disorders/*physiopathology , Epilepsy, Temporal Lobe/*physiopathology , Hippocampus/*growth & development , Neurogenesis/*genetics, Animals ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cognition Disorders/chemically induced ; Cognition Disorders/etiology ; Disease Models, Animal ; Doublecortin Domain Proteins ; Epilepsy/chemically induced ; Epilepsy/complications ; Epilepsy/physiopathology ; Epilepsy, Temporal Lobe/chemically induced ; Epilepsy, Temporal Lobe/complications ; Hippocampus/metabolism ; Hippocampus/physiopathology ; Immunohistochemistry ; Mice ; Mice, Transgenic ; Microtubule-Associated Proteins/metabolism ; Muscarinic Agonists/toxicity ; Nerve Tissue Proteins/metabolism ; Neural Stem Cells ; Neurogenesis/physiology ; Neurons/metabolism ; Neuropeptides/metabolism ; Pilocarpine/toxicity
مستخلص: Acute seizures after a severe brain insult can often lead to epilepsy and cognitive impairment. Aberrant hippocampal neurogenesis follows the insult but the role of adult-generated neurons in the development of chronic seizures or associated cognitive deficits remains to be determined. Here we show that the ablation of adult neurogenesis before pilocarpine-induced acute seizures in mice leads to a reduction in chronic seizure frequency. We also show that ablation of neurogenesis normalizes epilepsy-associated cognitive deficits. Remarkably, the effect of ablating adult neurogenesis before acute seizures is long lasting as it suppresses chronic seizure frequency for nearly 1 year. These findings establish a key role of neurogenesis in chronic seizure development and associated memory impairment and suggest that targeting aberrant hippocampal neurogenesis may reduce recurrent seizures and restore cognitive function following a pro-epileptic brain insult.
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معلومات مُعتمدة: R01 NS038572 United States NS NINDS NIH HHS; R01 DA016765 United States DA NIDA NIH HHS; R21 MH094715 United States MH NIMH NIH HHS; R01NS081203 United States NS NINDS NIH HHS; R01DA016765 United States DA NIDA NIH HHS; K02AG041815 United States AG NIA NIH HHS; R01 AG032383 United States AG NIA NIH HHS; 5T32GM083831-05 United States GM NIGMS NIH HHS; T32 GM083831 United States GM NIGMS NIH HHS; R01AG032383 United States AG NIA NIH HHS; T32 HL007360 United States HL NHLBI NIH HHS; 5T32HL007360-34 United States HL NHLBI NIH HHS; R01 NS081203 United States NS NINDS NIH HHS; R01 NS076775 United States NS NINDS NIH HHS; R01NS076775 United States NS NINDS NIH HHS; R01NS038572 United States NS NINDS NIH HHS; K02 AG041815 United States AG NIA NIH HHS; K02 DA023555 United States DA NIDA NIH HHS; K02DA023555 United States DA NIDA NIH HHS; R01 NS048192 United States NS NINDS NIH HHS; R21 DA023701 United States DA NIDA NIH HHS
المشرفين على المادة: 0 (Basic Helix-Loop-Helix Transcription Factors)
0 (Doublecortin Domain Proteins)
0 (Microtubule-Associated Proteins)
0 (Muscarinic Agonists)
0 (Nerve Tissue Proteins)
0 (Neuropeptides)
01MI4Q9DI3 (Pilocarpine)
169238-82-8 (Neurogenic differentiation factor 1)
تواريخ الأحداث: Date Created: 20150327 Date Completed: 20160325 Latest Revision: 20220310
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4375780
DOI: 10.1038/ncomms7606
PMID: 25808087
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/ncomms7606