دورية أكاديمية
أعرض في EDS

Mesoscale nanoparticles selectively target the renal proximal tubule epithelium.

التفاصيل البيبلوغرافية
العنوان: Mesoscale nanoparticles selectively target the renal proximal tubule epithelium.
المؤلفون: Williams RM; †Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States., Shah J; †Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States., Ng BD; †Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States., Minton DR; ‡Weill Cornell Graduate School of Medical Sciences, New York, New York 10065, United States., Gudas LJ; §Department of Pharmacology, Weill Cornell Medical College, New York, New York 10065, United States., Park CY; †Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.; ⊥Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, New York 10065., Heller DA; †Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.; §Department of Pharmacology, Weill Cornell Medical College, New York, New York 10065, United States.
المصدر: Nano letters [Nano Lett] 2015 Apr 08; Vol. 15 (4), pp. 2358-64. Date of Electronic Publication: 2015 Mar 26.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101088070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-6992 (Electronic) Linking ISSN: 15306984 NLM ISO Abbreviation: Nano Lett Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : American Chemical Society, c2001-
مواضيع طبية MeSH: Epithelium/*chemistry , Kidney Tubules, Proximal/*chemistry , Nanocapsules/*chemistry , Nanocapsules/*ultrastructure , Polyethylene Glycols/*chemical synthesis , Polyglactin 910/*chemical synthesis, Animals ; Female ; Materials Testing ; Mice ; Mice, Nude ; Organ Specificity ; Particle Size ; Tissue Distribution
مستخلص: We synthesized "mesoscale" nanoparticles, approximately 400 nm in diameter, which unexpectedly localized selectively in renal proximal tubules and up to 7 times more efficiently in the kidney than other organs. Although nanoparticles typically localize in the liver and spleen, modulating their size and opsonization potential allowed for stable targeting of the kidneys through a new proposed uptake mechanism. Applying this kidney targeting strategy, we anticipate use in the treatment of renal disease and the study of renal physiology.
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معلومات مُعتمدة: DP2 HD075698 United States HD NICHD NIH HHS; T32 CA062948 United States CA NCI NIH HHS; 2 P30 CA008748-48 United States CA NCI NIH HHS; DP2-HD075698 United States DP NCCDPHP CDC HHS; T32CA062948 United States CA NCI NIH HHS; 1 S10 OD016207-01 United States OD NIH HHS; P30 CA008748 United States CA NCI NIH HHS; S10 OD016207 United States OD NIH HHS
فهرسة مساهمة: Keywords: Nanotechnology; cancer; controlled release; nanomedicine; targeted drug delivery
المشرفين على المادة: 0 (Nanocapsules)
0 (poly(lactic-glycolic acid)-poly(ethyleneglycol) copolymer)
34346-01-5 (Polyglactin 910)
3WJQ0SDW1A (Polyethylene Glycols)
تواريخ الأحداث: Date Created: 20150327 Date Completed: 20160405 Latest Revision: 20240323
رمز التحديث: 20240323
مُعرف محوري في PubMed: PMC4518714
DOI: 10.1021/nl504610d
PMID: 25811353
قاعدة البيانات: MEDLINE
الوصف
تدمد:1530-6992
DOI:10.1021/nl504610d