دورية أكاديمية
أعرض في EDS

Concordance between 11C-PIB-PET and clinical diagnosis in a memory clinic.

التفاصيل البيبلوغرافية
العنوان: Concordance between 11C-PIB-PET and clinical diagnosis in a memory clinic.
المؤلفون: Patricio CM; Ageing and Memory Center, Instituto de Investigaciones Neurologicas 'Raúl Carrea' (FLENI), Buenos Aires, Argentina patriciochrem@gmail.com., Gabriela C; Ageing and Memory Center, Instituto de Investigaciones Neurologicas 'Raúl Carrea' (FLENI), Buenos Aires, Argentina., Julieta RM; Ageing and Memory Center, Instituto de Investigaciones Neurologicas 'Raúl Carrea' (FLENI), Buenos Aires, Argentina., Marcos FS; Ageing and Memory Center, Instituto de Investigaciones Neurologicas 'Raúl Carrea' (FLENI), Buenos Aires, Argentina., Federico N; Ageing and Memory Center, Instituto de Investigaciones Neurologicas 'Raúl Carrea' (FLENI), Buenos Aires, Argentina., Griselda R; Ageing and Memory Center, Instituto de Investigaciones Neurologicas 'Raúl Carrea' (FLENI), Buenos Aires, Argentina., Claudio W; Ageing and Memory Center, Instituto de Investigaciones Neurologicas 'Raúl Carrea' (FLENI), Buenos Aires, Argentina., Santiago P; Ageing and Memory Center, Instituto de Investigaciones Neurologicas 'Raúl Carrea' (FLENI), Buenos Aires, Argentina., Leonardo T; Ageing and Memory Center, Instituto de Investigaciones Neurologicas 'Raúl Carrea' (FLENI), Buenos Aires, Argentina., Jorge C; Ageing and Memory Center, Instituto de Investigaciones Neurologicas 'Raúl Carrea' (FLENI), Buenos Aires, Argentina., Alejandra A; Ageing and Memory Center, Instituto de Investigaciones Neurologicas 'Raúl Carrea' (FLENI), Buenos Aires, Argentina., Janus K; Ageing and Memory Center, Instituto de Investigaciones Neurologicas 'Raúl Carrea' (FLENI), Buenos Aires, Argentina., Salvador G; Ageing and Memory Center, Instituto de Investigaciones Neurologicas 'Raúl Carrea' (FLENI), Buenos Aires, Argentina., Ramon L; Ageing and Memory Center, Instituto de Investigaciones Neurologicas 'Raúl Carrea' (FLENI), Buenos Aires, Argentina., Gustavo S; Ageing and Memory Center, Instituto de Investigaciones Neurologicas 'Raúl Carrea' (FLENI), Buenos Aires, Argentina., Silvia V; Ageing and Memory Center, Instituto de Investigaciones Neurologicas 'Raúl Carrea' (FLENI), Buenos Aires, Argentina., Ricardo A; Ageing and Memory Center, Instituto de Investigaciones Neurologicas 'Raúl Carrea' (FLENI), Buenos Aires, Argentina.
المصدر: American journal of Alzheimer's disease and other dementias [Am J Alzheimers Dis Other Demen] 2015 Sep; Vol. 30 (6), pp. 599-606. Date of Electronic Publication: 2015 Mar 26.
نوع المنشور: Journal Article; Observational Study
اللغة: English
بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 101082834 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-2731 (Electronic) Linking ISSN: 15333175 NLM ISO Abbreviation: Am J Alzheimers Dis Other Demen Subsets: MEDLINE
أسماء مطبوعة: Publication: Thousand Oaks, Calif. : Sage Publications
Original Publication: Weston, MA : Prime National Pub. Corp., c2000-
مواضيع طبية MeSH: Amnesia/*diagnosis , Amyloid beta-Peptides/*metabolism , Cerebral Amyloid Angiopathy/*diagnosis , Cerebral Cortex/*metabolism , Cognitive Dysfunction/*diagnosis , Dementia/*diagnosis , Positron-Emission Tomography/*standards, Aged ; Alzheimer Disease/diagnosis ; Aniline Compounds ; Aphasia, Primary Progressive/diagnosis ; Atrophy/diagnosis ; Benzothiazoles ; Cerebral Cortex/pathology ; Female ; Frontotemporal Lobar Degeneration/diagnosis ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Thiazoles
مستخلص: Introduction: Today, ligands that bind to fibrillar β-amyloid are detectable by Positron Emission Tomography (PET) allowing for in vivo visualization for Abeta burden. However, amyloid plaques detection per se does not establish Alzheimer's Disease diagnosis. In this sense, the utility of amyloid imaging to improve clinical diagnosis was settled only for specific clinical scenarios and few studies have assessed amyloid molecular neuroimaging in a broader clinical setting. The aim of this study is to determine the frequency of PiB amyloid findings in different diagnostic syndromes grouped into high and low probability pre- test categories, taking into account pre-test clinical assumption of the presence of AD related pathology.
Methods: 144 patients were assigned into categories of high or low pretest probability according to clinical suspicion of AD pathology. The high probability group included: amnestic Mild Cognitive Impairment (MCI), amnestic and other domains MCI, Dementia of Alzheimer's Type (DAT), Posterior Cortical Atrophy (PCA), logopenic Primary Progressive Aphasia (PPA), Cerebral Amyloid Angiopathy and mixed dementia. The low assumption group included: normal controls, non-amnestic MCI, non-logopenic PPA and Frontotemporal Dementia (FTD).
Results: Only normal controls and DAT patients (typical and atypical presentation) were the most consistent across clinical and molecular diagnostics. MCI, non-logopenic PPA and FTD were the syndromic diagnoses that most discrepancies were found.
Discussion: This study demonstrates that detecting in vivo amyloid plaques by molecular imaging is considerably frequent in most of the dementia syndromes and shows that there are frequent discordance between molecular diagnosis and clinical assumption.
(© The Author(s) 2015.)
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فهرسة مساهمة: Keywords: 11C-PIB-PET; amyloid; memory clinic; neuroimaging
المشرفين على المادة: 0 (2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole)
0 (Amyloid beta-Peptides)
0 (Aniline Compounds)
0 (Benzothiazoles)
0 (Thiazoles)
تواريخ الأحداث: Date Created: 20150331 Date Completed: 20160526 Latest Revision: 20240402
رمز التحديث: 20240402
مُعرف محوري في PubMed: PMC10852556
DOI: 10.1177/1533317515576387
PMID: 25817631
قاعدة البيانات: MEDLINE
الوصف
تدمد:1938-2731
DOI:10.1177/1533317515576387