دورية أكاديمية
Organization of a type I keratin gene. Evidence for evolution of intermediate filaments from a common ancestral gene.
| العنوان: | Organization of a type I keratin gene. Evidence for evolution of intermediate filaments from a common ancestral gene. |
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| المؤلفون: | Krieg TM, Schafer MP, Cheng CK, Filpula D, Flaherty P, Steinert PM, Roop DR |
| المصدر: | The Journal of biological chemistry [J Biol Chem] 1985 May 25; Vol. 260 (10), pp. 5867-70. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print Cited Medium: Print ISSN: 0021-9258 (Print) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [New York, NY] : Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Original Publication: Baltimore, MD : American Society for Biochemistry and Molecular Biology |
| مواضيع طبية MeSH: | Genes*, Keratins/*genetics, Animals ; Base Sequence ; Biological Evolution ; Chromosome Mapping ; Cloning, Molecular ; Cricetinae ; DNA/genetics ; Humans ; Intermediate Filament Proteins/genetics ; Mice ; Vimentin/genetics |
| مستخلص: | The genomic structure of the mouse 59-kDa keratin gene, a Type I intermediate filament (IF) gene is presented. A comparison of the organization of this gene with that of the human 67-kDa keratin, a Type II IF gene, and hamster vimentin, a Type III IF gene, suggests a common evolutionary origin for Type I, II, and III IF genes. Most introns in these three types of IF genes occur at similar positions within the region encoding sequences predicted to form coiled-coils, but do not delineate structural subdomains. Interestingly though, most of the introns interrupt at or near the beginning of the characteristic 7-residue (heptad) repeat of sequences which form the coiled-coil. These data suggest that the three types of IF genes arose from a common ancestor which may have been assembled from smaller units containing multiple heptad repeats. Subsequent duplication events may then have formed the three known alpha-helical types and each of their various members. |
| سلسلة جزيئية: | GENBANK K00391; L00193; M10081 |
| المشرفين على المادة: | 0 (Intermediate Filament Proteins) 0 (Vimentin) 68238-35-7 (Keratins) 9007-49-2 (DNA) |
| تواريخ الأحداث: | Date Created: 19850525 Date Completed: 19850627 Latest Revision: 20210210 |
| رمز التحديث: | 20240627 |
| PMID: | 2581944 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0021-9258 |
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