دورية أكاديمية
[Influence of delta-sleep peptide on the enzymes activity of mitochondrial electron transport chain in various rat tissues during aging of the organism].
| العنوان: | [Influence of delta-sleep peptide on the enzymes activity of mitochondrial electron transport chain in various rat tissues during aging of the organism]. |
|---|---|
| المؤلفون: | Bondarenko TI, Kutilin DS, Mikhaleva II |
| المصدر: | Advances in gerontology = Uspekhi gerontologii [Adv Gerontol] 2014; Vol. 27 (3), pp. 496-502. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Ėskulap Country of Publication: Russia (Federation) NLM ID: 100971443 Publication Model: Print Cited Medium: Print ISSN: 1561-9125 (Print) Linking ISSN: 15619125 NLM ISO Abbreviation: Adv Gerontol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Sankt-Peterburg : Ėskulap, |
| مواضيع طبية MeSH: | Aging/*drug effects , Delta Sleep-Inducing Peptide/*pharmacology , Mitochondria/*drug effects , NADH Dehydrogenase/*metabolism, Aging/metabolism ; Animals ; Antioxidants/metabolism ; Brain/drug effects ; Brain/enzymology ; Brain/metabolism ; Delta Sleep-Inducing Peptide/administration & dosage ; Electron Transport/drug effects ; Free Radicals/metabolism ; Injections, Subcutaneous ; Liver/drug effects ; Liver/enzymology ; Liver/metabolism ; Male ; Mitochondria/enzymology ; Mitochondria/physiology ; Myocardium/enzymology ; Myocardium/metabolism ; Rats |
| مستخلص: | It is shown that subcutaneous injection of exogenous delta-sleep inducing peptide (DSIP) to rats aged 2-24 months in a dose of 100 μg/kg animal body weight by courses of 5 consecutive days per month has a stabilizing effect on the NADH-dehydrogenase activity in the mitochondrial fractions of various tissues, which together with increasing capacity of the antioxidant system should reduce the production of free radicals and their adverse action on cells macromolecule, herewith the activity of succinate dehydrogenase did not change. |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Free Radicals) 69431-45-4 (Delta Sleep-Inducing Peptide) EC 1.6.99.3 (NADH Dehydrogenase) |
| تواريخ الأحداث: | Date Created: 20150402 Date Completed: 20150908 Latest Revision: 20161021 |
| رمز التحديث: | 20221213 |
| PMID: | 25826998 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1561-9125 |
|---|