دورية أكاديمية
Oxidative airway inflammation leads to systemic and vascular oxidative stress in a murine model of allergic asthma.
| العنوان: | Oxidative airway inflammation leads to systemic and vascular oxidative stress in a murine model of allergic asthma. |
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| المؤلفون: | Al-Harbi NO; Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Nadeem A; Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Electronic address: anadeem@ksu.edu.sa., Al-Harbi MM; Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Imam F; Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Al-Shabanah OA; Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Ahmad SF; Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Sayed-Ahmed MM; Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Bahashwan SA; Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Medina, Saudi Arabia. |
| المصدر: | International immunopharmacology [Int Immunopharmacol] 2015 May; Vol. 26 (1), pp. 237-45. Date of Electronic Publication: 2015 Apr 03. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier Science, c2001- |
| مواضيع طبية MeSH: | Antioxidants/*therapeutic use , Aorta/*drug effects , Asthma/*immunology , Hydrogen Peroxide/*toxicity , Oxidative Stress/*drug effects , Respiratory Hypersensitivity/*immunology, Animals ; Antioxidants/metabolism ; Aorta/immunology ; Aorta/metabolism ; Asthma/drug therapy ; Asthma/metabolism ; Disease Models, Animal ; Female ; Inhalation Exposure ; Lipid Peroxidation/drug effects ; Lipid Peroxidation/immunology ; Ovalbumin/immunology ; Oxidative Stress/immunology ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Respiratory Hypersensitivity/drug therapy ; Respiratory Hypersensitivity/metabolism |
| مستخلص: | Oxidant-antioxidant imbalance plays an important role in repeated cycles of airway inflammation observed in asthma. It is when reactive oxygen species (ROS) overwhelm antioxidant defenses that a severe inflammatory state becomes apparent and may impact vasculature. Several studies have shown an association between airway inflammation and cardiovascular complications; however so far none has investigated the link between airway oxidative stress and systemic/vascular oxidative stress in a murine model of asthma. Therefore, this study investigated the contribution of oxidative stress encountered in asthmatic airways in modulation of vascular/systemic oxidant-antioxidant balance. Rats were sensitized intraperitoneally with ovalbumin (OVA) in the presence of aluminum hydroxide followed by several intranasal (i.n.) challenges with OVA. Rats were then assessed for airway and vascular inflammation, oxidative stress (ROS, lipid peroxides) and antioxidants measured as total antioxidant capacity (TAC) and thiol content. Challenge with OVA led to increased airway inflammation and oxidative stress with a concomitant increase in vascular inflammation and oxidative stress. Oxidative stress in the vasculature was significantly inhibited by antioxidant treatment, N-acetyl cysteine; whereas hydrogen peroxide (H2O2) inhalation worsened it. Therefore, our study shows that oxidative airway inflammation is associated with vascular/systemic oxidative stress which might predispose these patients to increased cardiovascular risk. (Copyright © 2015 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Airway inflammation; Allergens; Antioxidants; Aorta; Blood; Oxidative stress |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Reactive Oxygen Species) 9006-59-1 (Ovalbumin) BBX060AN9V (Hydrogen Peroxide) |
| تواريخ الأحداث: | Date Created: 20150407 Date Completed: 20160216 Latest Revision: 20220409 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.intimp.2015.03.032 |
| PMID: | 25843257 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-1705 |
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| DOI: | 10.1016/j.intimp.2015.03.032 |