دورية أكاديمية
أعرض في EDS

Dietary n-3 polyunsaturated fatty acid intakes modify the effect of genetic variation in fatty acid desaturase 1 on coronary artery disease.

التفاصيل البيبلوغرافية
العنوان: Dietary n-3 polyunsaturated fatty acid intakes modify the effect of genetic variation in fatty acid desaturase 1 on coronary artery disease.
المؤلفون: Liu F; Department of Epidemiology and health statistics, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China., Li Z; Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, Guangdong, China., Lv X; Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, Guangdong, China., Ma J; Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, Guangdong, China.
المصدر: PloS one [PLoS One] 2015 Apr 07; Vol. 10 (4), pp. e0121255. Date of Electronic Publication: 2015 Apr 07 (Print Publication: 2015).
نوع المنشور: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Coronary Artery Disease*/blood , Coronary Artery Disease*/genetics , Dietary Supplements* , Docosahexaenoic Acids*/administration & dosage , Docosahexaenoic Acids*/pharmacokinetics , Eicosapentaenoic Acid*/administration & dosage , Eicosapentaenoic Acid*/pharmacokinetics , Polymorphism, Single Nucleotide*, Fatty Acid Desaturases/*genetics, Aged ; Asian People ; China ; Delta-5 Fatty Acid Desaturase ; Female ; Humans ; Male ; Middle Aged
مستخلص: Background: Previous studies suggested that dietary fatty acids could affect blood lipids by interacting with genetic variations in fatty acid desaturase 1 (FADS1). However, little is known about their direct effects on coronary artery disease (CAD). The aim of this study was to evaluate whether dietary n-3 long-chain polyunsaturated fatty acids (LCPUFAs)-eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) could modulate the effect of FADS1 rs174547 polymorphism on CAD.
Methods: FADS1 single-nucleotide polymorphisms rs174547 genotypes were measured in 440 CAD patients and 838 healthy controls. Dietary EPA and DHA intakes were assessed with a validated quantitative frequency food questionnaire. The association between FADS1 rs174547 and CAD was estimated using logistic regression under both dominant and additive genetic models. The interactions between rs174547 polymorphism and LCPUFAs were analyzed by using multiple logistic regression and the "genotype × n-3 LCPUFAs" interaction term was included into the model.
Results: We found that the minor T allele of FADS1 rs174547 increased CAD risk (OR = 1.36, 95%CIs 1.03-1.80), and observed significant interaction between rs174547 and dietary EPA intakes on CAD (P-interaction = 0.028). The T-allele was only associated with higher CAD risk among individuals with lower dietary EPA intakes, but not in those with higher EPA intakes. Similarly, significant interaction was also observed between rs174547 and dietary DHA intakes on CAD (P-interaction = 0.020).
Conclusions: Dietary n-3 LCPUFA intakes could modulate the association between FADS1 rs174547 polymorphism and CAD. High dietary n-3 LCPUFA intakes could negate the unfavorable effect of genetic variation in FADS1 on CAD in middle-aged and elderly Chinese population.
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المشرفين على المادة: 0 (Delta-5 Fatty Acid Desaturase)
25167-62-8 (Docosahexaenoic Acids)
AAN7QOV9EA (Eicosapentaenoic Acid)
EC 1.14.19.- (Fatty Acid Desaturases)
EC 1.14.19.3 (FADS1 protein, human)
تواريخ الأحداث: Date Created: 20150408 Date Completed: 20160327 Latest Revision: 20221207
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4388373
DOI: 10.1371/journal.pone.0121255
PMID: 25849351
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0121255