دورية أكاديمية

Serum selenium and ceruloplasmin in nigerians with peripartum cardiomyopathy.

التفاصيل البيبلوغرافية
العنوان: Serum selenium and ceruloplasmin in nigerians with peripartum cardiomyopathy.
المؤلفون: Karaye KM; Department of Medicine, Bayero University and Aminu Kano Teaching Hospital, PO Box 4445, Kano, Nigeria. kkaraye@yahoo.co.uk.; Department of Public Health and Clinical Medicine, Umea University, SE-901 87 Umea, Sweden. kkaraye@yahoo.co.uk., Yahaya IA; Department of Chemical Pathology, Bayero University and Aminu Kano Teaching Hospital, Kano, Nigeria. yahadagiri2@yahoo.com., Lindmark K; Department of Public Health and Clinical Medicine, Umea University, SE-901 87 Umea, Sweden. krister.lindmark@vll.se.; Department of Cardiology, Umea Heart Centre, SE-901 85 Umea, Sweden. krister.lindmark@vll.se., Henein MY; Department of Public Health and Clinical Medicine, Umea University, SE-901 87 Umea, Sweden. michael.henein@umu.se.; Department of Cardiology, Umea Heart Centre, SE-901 85 Umea, Sweden. michael.henein@umu.se.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2015 Apr 07; Vol. 16 (4), pp. 7644-54. Date of Electronic Publication: 2015 Apr 07.
نوع المنشور: Journal Article; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Cardiomyopathies/*etiology , Ceruloplasmin/*metabolism , Peripartum Period/*blood , Selenium/*deficiency, Adult ; Cardiomyopathies/blood ; Cardiomyopathies/enzymology ; Case-Control Studies ; Female ; Humans ; Nigeria ; Rural Population ; Selenium/blood ; Socioeconomic Factors ; Young Adult
مستخلص: The study aimed to determine if selenium deficiency, serum ceruloplasmin and traditional birth practices are risk factors for peripartum cardiomyopathy (PPCM), in Kano, Nigeria. This is a case-control study carried out in three hospitals, and PPCM patients were followed up for six months. Critically low serum selenium concentration was defined as <70 µg/L. A total of 39 PPCM patients and 50 controls were consecutively recruited after satisfying the inclusion criteria. Mean serum selenium in patients (61.7 ± 14.9 µg/L) was significantly lower than in controls (118.4 ± 45.6 µg/L) (p < 0.001). The prevalence of serum selenium <70 µg/L was significantly higher among patients (76.9%) than controls (22.0%) (p < 0.001). The mean ceruloplasmin and prevalence of socio-economic indices, multiparity, pregnancy-induced hypertension, obesity and twin pregnancy were not different between the groups (p > 0.05). Logistic regression showed that rural residency significantly increased the odds for serum selenium <70 µg/L by 2.773-fold (p = 0.037). Baseline serum levels of selenium and ceruloplasmin were not associated with six-month mortality. This study has shown that selenium deficiency is a risk factor for PPCM in Kano, Nigeria, and is related to rural residency. However, serum ceruloplasmin, customary birth practices and some other characteristics were not associated with PPCM in the study area.
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المشرفين على المادة: EC 1.16.3.1 (Ceruloplasmin)
H6241UJ22B (Selenium)
تواريخ الأحداث: Date Created: 20150409 Date Completed: 20160104 Latest Revision: 20230403
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4425040
DOI: 10.3390/ijms16047644
PMID: 25853263
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms16047644