دورية أكاديمية
أعرض في EDS

Higher circulating adiponectin levels are associated with increased risk of atrial fibrillation in older adults.

التفاصيل البيبلوغرافية
العنوان: Higher circulating adiponectin levels are associated with increased risk of atrial fibrillation in older adults.
المؤلفون: Macheret F; Department of Medicine, Penn Presbyterian Medical Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA., Bartz TM; Department of Biostatistics, University of Washington, Seattle, Washington, USA., Djousse L; Division of Aging, Department of Medicine, Brigham and Women's Hospital and Boston VA Healthcare System, Boston, Massachusetts, USA., Ix JH; Department of Medicine, and the Division of Preventive Medicine, Department of Family and Preventive Medicine, University of California San Diego, and Nephrology Section, Veteran Affairs San Diego Health Care System, San Diego, California, USA., Mukamal KJ; Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Zieman SJ; Division of Geriatrics and Clinical Gerontology, National Institute on Aging, Bethesda, Maryland, USA., Siscovick DS; New York Academy of Medicine, New York, New York, USA., Tracy RP; Departments of Pathology and Biochemistry, University of Vermont, Burlington, Vermont, USA., Heckbert SR; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, and Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, and Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA., Kizer JR; Department of Medicine, and Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
المصدر: Heart (British Cardiac Society) [Heart] 2015 Sep; Vol. 101 (17), pp. 1368-74. Date of Electronic Publication: 2015 Apr 08.
نوع المنشور: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 9602087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-201X (Electronic) Linking ISSN: 13556037 NLM ISO Abbreviation: Heart Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BMJ Pub. Group, c1996-
مواضيع طبية MeSH: Adiponectin/*blood , Aging/*blood , Atrial Fibrillation/*blood, Age Factors ; Aged ; Aged, 80 and over ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Biomarkers/blood ; Female ; Humans ; Incidence ; Linear Models ; Male ; Multivariate Analysis ; Natriuretic Peptide, Brain/blood ; Peptide Fragments/blood ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; United States/epidemiology ; Up-Regulation
مستخلص: Background: Adiponectin has cardioprotective properties, suggesting that lower levels seen in obesity and diabetes could heighten risk of atrial fibrillation (AF). Among older adults, however, higher adiponectin has been linked to greater incidence of adverse outcomes associated with AF, although recent reports have shown this association to be U-shaped. We postulated that higher adiponectin would be linked to increased risk for AF in older adults in a U-shaped manner.
Methods: We examined the associations of total and high-molecular-weight (HMW) adiponectin with incident AF among individuals free of prevalent cardiovascular disease (CVD) participating in a population-based cohort study of older adults (n=3190; age=74±5 years).
Results: During median follow-up of 11.4 years, there were 886 incident AF events. Adjusted cubic splines showed a positive and linear association between adiponectin and incident AF. After adjusting for potential confounders, including amino-terminal pro-B-type natriuretic peptide 1-76, the HR (95% CI) for AF per SD increase in total adiponectin was 1.14 (1.05 to 1.24), while that for HMW adiponectin was 1.17 (1.08 to 1.27). Additional adjustment for putative mediators, including subclinical CVD, diabetes, lipids and inflammation, did not significantly affect these estimates.
Conclusions: The present findings demonstrate that higher, not lower, levels of adiponectin are independently associated with increased risk of AF in older adults despite its documented cardiometabolic benefits. Additional work is necessary to determine if adiponectin is a marker of failed counter-regulatory pathways or whether this hormone is directly harmful in the setting of or as a result of advanced age.
Competing Interests: Disclosures: None.
(Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.)
التعليقات: Comment in: Heart. 2015 Sep;101(17):1351-2. (PMID: 26025085)
Comment in: Heart. 2016 Feb;102(3):254. (PMID: 26769380)
Comment in: Heart. 2016 Feb;102(3):254. (PMID: 26769381)
References: Circulation. 2009 Nov 3;120(18):1768-74. (PMID: 19841297)
Diabetes. 2013 Apr;62(4):1007-9. (PMID: 23520272)
JAMA. 2010 Dec 8;304(22):2494-502. (PMID: 21078811)
Circulation. 2009 Feb 3;119(4):606-18. (PMID: 19188521)
Am Heart J. 2012 Jan;163(1):119-124.e1. (PMID: 22172445)
Circulation. 2012 Dec 18;126(25):2951-61. (PMID: 23159554)
J Clin Endocrinol Metab. 2013 Jan;98(1):255-63. (PMID: 23162097)
Circulation. 2014 Jan 21;129(3):e28-e292. (PMID: 24352519)
J Gerontol A Biol Sci Med Sci. 2010 Nov;65(11):1208-14. (PMID: 20616148)
Eur J Epidemiol. 2014 Mar;29(3):181-90. (PMID: 24389686)
Ann Epidemiol. 1995 Jul;5(4):270-7. (PMID: 8520708)
Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1219-21. (PMID: 18565846)
Circulation. 2003 Dec 16;108(24):3006-10. (PMID: 14623805)
Circulation. 2008 Mar 11;117(10):1255-60. (PMID: 18285562)
Cardiovasc Res. 2008 Jul 15;79(2):279-86. (PMID: 18474523)
Circ Heart Fail. 2012 May 1;5(3):340-8. (PMID: 22379072)
Circulation. 2010 Jan 19;121(2):200-7. (PMID: 20048208)
J Am Coll Cardiol. 2009 Jun 2;53(22):2070-7. (PMID: 19477358)
Nat Med. 2005 Oct;11(10):1096-103. (PMID: 16155579)
Am J Cardiol. 2014 Jan 15;113(2):328-34. (PMID: 24169012)
Clin Chem. 1995 Feb;41(2):264-70. (PMID: 7874780)
Eur Heart J. 2008 May;29(9):1168-80. (PMID: 18390538)
Int J Cardiol. 2009 Feb 20;132(2):221-6. (PMID: 18192035)
Kidney Int. 1995 Jan;47(1):312-8. (PMID: 7731163)
Metabolism. 2014 Sep;63(9):1079-83. (PMID: 25038728)
PLoS Genet. 2012;8(3):e1002607. (PMID: 22479202)
JAMA. 2004 Nov 24;292(20):2471-7. (PMID: 15562125)
Ann Epidemiol. 1991 Feb;1(3):263-76. (PMID: 1669507)
Circ Heart Fail. 2010 Mar;3(2):185-94. (PMID: 20103776)
Diabetologia. 1985 Jul;28(7):412-9. (PMID: 3899825)
معلومات مُعتمدة: U01 HL080295 United States HL NHLBI NIH HHS; HHSN268200800007C United States HL NHLBI NIH HHS; N01HC55222 United States HL NHLBI NIH HHS; R01 HL094555 United States HL NHLBI NIH HHS; N01HC85086 United States HL NHLBI NIH HHS; HHSN268201200036C United States HL NHLBI NIH HHS; R01 HL080295 United States HL NHLBI NIH HHS; HHSN268200800007C United States PHS HHS; N01HC85082 United States HL NHLBI NIH HHS; N01HC85083 United States HL NHLBI NIH HHS; HHSN268201200036C United States PHS HHS; HL080295 United States HL NHLBI NIH HHS; N01HC85079 United States HL NHLBI NIH HHS; R01 AG023629 United States AG NIA NIH HHS; N01HC85080 United States HL NHLBI NIH HHS; AG023629 United States AG NIA NIH HHS; R56 AG023629 United States AG NIA NIH HHS; N01HC85081 United States HL NHLBI NIH HHS
المشرفين على المادة: 0 (ADIPOQ protein, human)
0 (Adiponectin)
0 (Biomarkers)
0 (Peptide Fragments)
0 (pro-brain natriuretic peptide (1-76))
114471-18-0 (Natriuretic Peptide, Brain)
تواريخ الأحداث: Date Created: 20150410 Date Completed: 20151105 Latest Revision: 20220321
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5161822
DOI: 10.1136/heartjnl-2014-307015
PMID: 25855796
قاعدة البيانات: MEDLINE
الوصف
تدمد:1468-201X
DOI:10.1136/heartjnl-2014-307015