دورية أكاديمية
Effects of nonsteroidal anti-inflammatory drugs on osseointegration: a review.
| العنوان: | Effects of nonsteroidal anti-inflammatory drugs on osseointegration: a review. |
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| المؤلفون: | Gomes FI; 1 Faculty of Dentistry, Federal University of Ceara, Sobral Campus, Sobral, Ceará, Brazil., Aragão MG, de Paulo Teixeira Pinto V, Gondim DV, Barroso FC, Silva AA, Bezerra MM, Chaves HV |
| المصدر: | The Journal of oral implantology [J Oral Implantol] 2015 Apr; Vol. 41 (2), pp. 219-30. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Academy Of Implant Dentistry Country of Publication: United States NLM ID: 7801086 Publication Model: Print Cited Medium: Internet ISSN: 1548-1336 (Electronic) Linking ISSN: 01606972 NLM ISO Abbreviation: J Oral Implantol |
| أسماء مطبوعة: | Publication: Lawrence Ks : Lawrence, KS : American Academy Of Implant Dentistry ; Co-published by Allen Press Publishing Services Original Publication: Abington, Mass., American Academy of Implant Dentistry. |
| مواضيع طبية MeSH: | Anti-Inflammatory Agents, Non-Steroidal*/pharmacology , Dental Implants* , Osseointegration*, Animals ; Cyclooxygenase 2 ; Double-Blind Method ; Humans ; Randomized Controlled Trials as Topic |
| مستخلص: | The purpose of this study was to review the effects of nonsteroidal anti-inflammatory drugs on osseointegration and determine whether they cause failures in dental implants and whether patients who use them chronically can receive dental implants safely. A bibliographic electronic search was performed using the Cochrane Library, PubMed, and Medline databases, selecting articles published between January 1982 and December 2012. The search included the following keywords, either alone or combined: "nonsteroidal anti-inflammatory drugs," "dental implants," "bone healing," and "osteoprogenitor cells." The inclusion criteria were the following: randomized, double-blind, placebo-controlled clinical studies, in vivo animal model studies of osseointegration, and in vitro studies of the effects of these agents on osteoprogenitor cells. The literature search revealed 360 references. A total of 31 articles met the inclusion criteria, including 2 clinical trials, 20 animal studies, and 9 osteoprogenitor cell studies. The clinical trials revealed that cyclooxygenase-1 (COX-1) inhibitors did not impair osseointegration. The animal studies showed that any drug that is capable of inhibiting COX-2 may impair the osseointegration process. The in vitro studies showed that COX-2 inhibitors are the most potent depressors of osseointegration at the cellular level. Caution must be taken when selecting COX-2 nonsteroidal anti-inflammatory drugs during the postoperative period. |
| فهرسة مساهمة: | Keywords: dental implants; nonsteroidal anti-inflammatory drugs; osseointegration |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents, Non-Steroidal) 0 (Dental Implants) EC 1.14.99.1 (Cyclooxygenase 2) |
| تواريخ الأحداث: | Date Created: 20150410 Date Completed: 20190325 Latest Revision: 20190325 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1563/AAID-JOI-D-13-00125 |
| PMID: | 25856049 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1548-1336 |
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| DOI: | 10.1563/AAID-JOI-D-13-00125 |