دورية أكاديمية
Microsomal lipid peroxidation: effect of vitamin E and its functional interaction with phospholipid hydroperoxide glutathione peroxidase.
| العنوان: | Microsomal lipid peroxidation: effect of vitamin E and its functional interaction with phospholipid hydroperoxide glutathione peroxidase. |
|---|---|
| المؤلفون: | Maiorino M; Department of Biological Chemistry, Padova University, Italy., Coassin M, Roveri A, Ursini F |
| المصدر: | Lipids [Lipids] 1989 Aug; Vol. 24 (8), pp. 721-6. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Subscription Services, Inc Country of Publication: United States NLM ID: 0060450 Publication Model: Print Cited Medium: Print ISSN: 0024-4201 (Print) Linking ISSN: 00244201 NLM ISO Abbreviation: Lipids Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2018- : Hoboken, NJ : Wiley Subscription Services, Inc. Original Publication: Chicago, American Oil Chemists' Society. |
| مواضيع طبية MeSH: | Lipid Peroxidation*, Glutathione/*metabolism , Glutathione Peroxidase/*metabolism , Microsomes, Liver/*metabolism , Vitamin E/*metabolism, Animals ; Hydrogen Peroxide/metabolism ; Lipid Peroxides/metabolism ; Oxygen Consumption ; Rats ; Vitamin E/pharmacology |
| مستخلص: | The role of vitamin E in the protection against iron dependent lipid peroxidation was studied in rat liver microsomes and Triton-dispersed microsomal lipid micelles. In these systems, an antioxidant effect of vitamin E at a physiological ratio to phospholipids could be observed only in the presence of phospholipid hydroperoxide glutathione peroxidase (PHGPX) and glutathione. The rationale of this cooperation is discussed on the basis of the hydroperoxyl radical scavenging capacity of vitamin E and the reduction of membrane hydroperoxides by PHGPX. The scavenging of lipid hydroperoxyl radicals by vitamin E, although inhibiting propagation of the peroxidative chain, produces lipid hydroperoxides from which ferrous iron generates alkoxyl radicals that react with vitamin E almost as fast as with fatty acids. Therefore, only if membrane hydroperoxides are continuously reduced by this specific peroxidase does the scavenging of hydroperoxyl radicals by vitamin E lead to an effective inhibition of lipid peroxidation. |
| References: | Chem Phys Lipids. 1987 Jul-Sep;44(2-4):227-53. (PMID: 3311418) Annu Rev Nutr. 1985;5:323-40. (PMID: 2992548) FEBS Lett. 1973 Feb 1;29(3):205-210. (PMID: 11946914) Anal Biochem. 1987 Dec;167(2):411-7. (PMID: 3442337) J Biol Chem. 1984 Apr 10;259(7):4177-82. (PMID: 6706998) Biochim Biophys Acta. 1982 Feb 15;710(2):197-211. (PMID: 7066358) Methods Enzymol. 1978;52:302-10. (PMID: 672633) Free Radic Biol Med. 1989;6(1):31-6. (PMID: 2492247) Arch Biochem Biophys. 1985 Jul;240(1):117-20. (PMID: 2990339) J Nutr Sci Vitaminol (Tokyo). 1977;23(4):273-80. (PMID: 915559) Methods Enzymol. 1984;105:131-8. (PMID: 6727661) Anal Biochem. 1987 Feb 15;161(1):45-8. (PMID: 3578786) Biochim Biophys Acta. 1985 Mar 29;839(1):62-70. (PMID: 3978121) Biochem Biophys Res Commun. 1963 Aug 14;12:388-94. (PMID: 14070351) |
| المشرفين على المادة: | 0 (Lipid Peroxides) 1406-18-4 (Vitamin E) BBX060AN9V (Hydrogen Peroxide) EC 1.11.1.9 (Glutathione Peroxidase) GAN16C9B8O (Glutathione) |
| تواريخ الأحداث: | Date Created: 19890801 Date Completed: 19891229 Latest Revision: 20190814 |
| رمز التحديث: | 20221208 |
| DOI: | 10.1007/BF02535211 |
| PMID: | 2586229 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 0024-4201 |
|---|---|
| DOI: | 10.1007/BF02535211 |