دورية أكاديمية
أعرض في EDS

Human monocyte heat shock protein 72 responses to acute hypoxic exercise after 3 days of exercise heat acclimation.

التفاصيل البيبلوغرافية
العنوان: Human monocyte heat shock protein 72 responses to acute hypoxic exercise after 3 days of exercise heat acclimation.
المؤلفون: Lee BJ; Exercise Science Applied Research Group, Coventry University, Priory Street, Coventry CV1 5FB, UK., Mackenzie RW; Inflammation and Infection Group, School of Science and Technology, University of Westminster, New Cavendish Street, London W1W 6UW, UK., Cox V; Exercise Science Applied Research Group, Coventry University, Priory Street, Coventry CV1 5FB, UK., James RS; Exercise Science Applied Research Group, Coventry University, Priory Street, Coventry CV1 5FB, UK., Thake CD; Exercise Science Applied Research Group, Coventry University, Priory Street, Coventry CV1 5FB, UK.
المصدر: BioMed research international [Biomed Res Int] 2015; Vol. 2015, pp. 849809. Date of Electronic Publication: 2015 Mar 22.
نوع المنشور: Clinical Trial; Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Co Country of Publication: United States NLM ID: 101600173 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Hindawi Pub. Co.
مواضيع طبية MeSH: Exercise* , Gene Expression Regulation* , Hot Temperature*, HSP72 Heat-Shock Proteins/*biosynthesis , Hypoxia/*metabolism , Monocytes/*metabolism, Acclimatization ; Adult ; Humans ; Male ; Time Factors
مستخلص: The aim of this study was to determine whether short-term heat acclimation (STHA) could confer increased cellular tolerance to acute hypoxic exercise in humans as determined via monocyte HSP72 (mHSP72) expression. Sixteen males were separated into two matched groups. The STHA group completed 3 days of exercise heat acclimation; 60 minutes cycling at 50% V̇O2peak in 40°C 20% relative humidity (RH). The control group (CON) completed 3 days of exercise training in 20°C, 40% RH. Each group completed a hypoxic stress test (HST) one week before and 48 hours following the final day of CON or STHA. Percentage changes in HSP72 concentrations were similar between STHA and CON following HST1 (P = 0.97). STHA induced an increase in basal HSP72 (P = 0.03) with no change observed in CON (P = 0.218). Basal mHSP72 remained elevated before HST2 for the STHA group (P < 0.05) and was unchanged from HST1 in CON (P > 0.05). Percent change in mHSP72 was lower after HST2 in STHA compared to CON (P = 0.02). The mHSP72 response to hypoxic exercise was attenuated following 3 days of heat acclimation. This is indicative of improved tolerance and ability to cope with the hypoxic insult, potentially mediated in part by increased basal reserves of HSP72.
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المشرفين على المادة: 0 (HSP72 Heat-Shock Proteins)
تواريخ الأحداث: Date Created: 20150416 Date Completed: 20151228 Latest Revision: 20181113
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4385626
DOI: 10.1155/2015/849809
PMID: 25874231
قاعدة البيانات: MEDLINE
الوصف
تدمد:2314-6141
DOI:10.1155/2015/849809