دورية أكاديمية
أعرض في EDS

Thyroid hormone and estrogen regulate exercise-induced growth hormone release.

التفاصيل البيبلوغرافية
العنوان: Thyroid hormone and estrogen regulate exercise-induced growth hormone release.
المؤلفون: Ignacio DL; Institute of Biophysics Carlos Chagas Filho and School of Physical Education and Sports, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., da S Silvestre DH; Institute of Biophysics Carlos Chagas Filho and School of Physical Education and Sports, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Cavalcanti-de-Albuquerque JP; Institute of Biophysics Carlos Chagas Filho and School of Physical Education and Sports, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Louzada RA; Institute of Biophysics Carlos Chagas Filho and School of Physical Education and Sports, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Carvalho DP; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Werneck-de-Castro JP; Institute of Biophysics Carlos Chagas Filho and School of Physical Education and Sports, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Department of Endocrinology and Metabolism, Rush University Medical Center, Chicago, Illinois, United States of America.
المصدر: PloS one [PLoS One] 2015 Apr 13; Vol. 10 (4), pp. e0122556. Date of Electronic Publication: 2015 Apr 13 (Print Publication: 2015).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Estrogens/*metabolism , Growth Hormone/*metabolism , Iodide Peroxidase/*metabolism , Thyroid Hormones/*metabolism, Animals ; Humans ; Iodide Peroxidase/antagonists & inhibitors ; Physical Conditioning, Animal ; Pituitary Gland/metabolism ; Propylthiouracil/administration & dosage ; Rats
مستخلص: Growth hormone (GH) regulates whole body metabolism, and physical exercise is the most potent stimulus to induce its secretion in humans. The mechanisms underlying GH secretion after exercise remain to be defined. The aim of this study was to elucidate the role of estrogen and pituitary type 1 deiodinase (D1) activation on exercise-induced GH secretion. Ten days after bilateral ovariectomy, animals were submitted to 20 min of treadmill exercise at 75% of maximum aerobic capacity and tissues were harvested immediately or 30 min after exercise. Non-exercised animals were used as controls. A significant increase in D1 activity occurred immediately after exercise (~60%) in sham-operated animals and GH was higher (~6-fold) 30 min after exercise. Estrogen deficient rats exhibited basal levels of GH and D1 activity comparable to those found in control rats. However, after exercise both D1 activity and serum GH levels were blunted compared to sedentary rats. To understand the potential cause-effect of D1 activation in exercise-induced GH release, we pharmacologically blocked D1 activity by propylthiouracil (PTU) injection into intact rats and submitted them to the acute exercise session. D1 inhibition blocked exercise-induced GH secretion, although basal levels were unaltered. In conclusion, estrogen deficiency impairs the induction of thyroid hormone activating enzyme D1 in the pituitary, and GH release by acute exercise. Also, acute D1 activation is essential for exercise-induced GH response.
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المشرفين على المادة: 0 (Estrogens)
0 (Thyroid Hormones)
721M9407IY (Propylthiouracil)
9002-72-6 (Growth Hormone)
EC 1.11.1.8 (Iodide Peroxidase)
تواريخ الأحداث: Date Created: 20150416 Date Completed: 20160108 Latest Revision: 20240714
رمز التحديث: 20240714
مُعرف محوري في PubMed: PMC4395113
DOI: 10.1371/journal.pone.0122556
PMID: 25874614
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0122556