دورية أكاديمية
Colistin and tobramycin resistance during long- term use of selective decontamination strategies in the intensive care unit: a post hoc analysis.
| العنوان: | Colistin and tobramycin resistance during long- term use of selective decontamination strategies in the intensive care unit: a post hoc analysis. |
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| المؤلفون: | Wittekamp BH; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. B.H.J.Wittekamp@umcutrecht.nl., Oostdijk EA; Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. E.A.N.Oostdijk@umcutrecht.nl., de Smet AM; CAPE, Critical Care, Anesthesiology, Peri-operative and Emergency Medicine Research Program, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands. A.M.G.A.de.Smet@umcg.nl., Bonten MJ; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. MBonten@umcutrecht.nl.; Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. MBonten@umcutrecht.nl. |
| المصدر: | Critical care (London, England) [Crit Care] 2015 Mar 25; Vol. 19, pp. 113. Date of Electronic Publication: 2015 Mar 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 9801902 Publication Model: Electronic Cited Medium: Internet ISSN: 1466-609X (Electronic) Linking ISSN: 13648535 NLM ISO Abbreviation: Crit Care Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London, UK : BioMed Central Ltd Original Publication: London : Current Science Ltd, c1997- |
| مواضيع طبية MeSH: | Drug Resistance, Bacterial*, Anti-Bacterial Agents/*administration & dosage , Colistin/*administration & dosage , Decontamination/*methods , Gastrointestinal Tract/*microbiology , Gram-Negative Bacteria/*drug effects , Respiratory Tract Infections/*microbiology , Tobramycin/*administration & dosage, Gram-Negative Bacteria/isolation & purification ; Humans ; Intensive Care Units ; Oropharynx/microbiology ; Randomized Controlled Trials as Topic |
| مستخلص: | Introduction: Selective decontamination of the digestive tract (SDD) and selective oropharyngeal decontamination (SOD) have been shown to improve intensive care unit (ICU) patients' outcomes. The aim of this study was to determine the effects of long-term use of SDD and SOD on colistin and tobramycin resistance among gram-negative bacteria. Methods: We performed a post hoc analysis of two consecutive multicentre cluster-randomised trials with crossover of interventions. SDD and SOD were alternately but continuously used during 7 years in five Dutch ICUs participating in two consecutive cluster-randomised trials. In both trials, to measure colistin and tobramycin resistance among gram-negative bacteria, rectal and respiratory samples were obtained monthly from all patients present in the ICU. Results: The prevalence of tobramycin resistance in respiratory and rectal samples decreased significantly during long-term use of SOD and SDD. (rectal samples risk ratio (RR) 0.35 (0.23 to 0.53); respiratory samples RR 0.48 (0.32 to 0.73), SDD compared to standard care). Colistin resistance in rectal and respiratory samples did not change (rectal samples RR 0.63 (0.29 to 1.38); respiratory samples RR 1.26 (0.35 to 4.57), SDD compared to standard care). Conclusions: In this study, in a setting with low antimicrobial resistance rates, the prevalence of resistance against colistin and tobramycin among gram-negative isolates did not increase during a mean of 7 years of SDD or SOD use. |
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| المشرفين على المادة: | 0 (Anti-Bacterial Agents) VZ8RRZ51VK (Tobramycin) Z67X93HJG1 (Colistin) |
| تواريخ الأحداث: | Date Created: 20150417 Date Completed: 20160104 Latest Revision: 20181113 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC4373110 |
| DOI: | 10.1186/s13054-015-0838-4 |
| PMID: | 25880968 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1466-609X |
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| DOI: | 10.1186/s13054-015-0838-4 |