دورية أكاديمية
أعرض في EDS

Situation analysis of parasitological and entomological indices of onchocerciasis transmission in three drainage basins of the rain forest of South West Cameroon after a decade of ivermectin treatment.

التفاصيل البيبلوغرافية
العنوان: Situation analysis of parasitological and entomological indices of onchocerciasis transmission in three drainage basins of the rain forest of South West Cameroon after a decade of ivermectin treatment.
المؤلفون: Wanji S; Parasite and Vectors Research Unit, Department of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon. swanji@yahoo.fr.; Research Foundation for Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon. swanji@yahoo.fr., Kengne-Ouafo JA; Parasite and Vectors Research Unit, Department of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon. arnaudkengne@yahoo.com.; Research Foundation for Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon. arnaudkengne@yahoo.com., Esum ME; Parasite and Vectors Research Unit, Department of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon. mathias_mesum@yahoo.fr.; Research Foundation for Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon. mathias_mesum@yahoo.fr., Chounna PW; Parasite and Vectors Research Unit, Department of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon. ndongmopatrick@yahoo.com.; Research Foundation for Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon. ndongmopatrick@yahoo.com., Tendongfor N; Parasite and Vectors Research Unit, Department of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon. ntendongfor@yahoo.com.; Research Foundation for Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon. ntendongfor@yahoo.com., Adzemye BF; Parasite and Vectors Research Unit, Department of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon. adzemye@gmail.com.; Research Foundation for Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon. adzemye@gmail.com., Eyong JE; Research Foundation for Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon. jeebanga@yahho.com.; Department of Biological Sciences, Faculty of Science, University of Bamenda, P.O. Box 39, Bambili, North West Region, Bamenda, Cameroon. jeebanga@yahho.com., Jato I; Tropical Medicine Research station, P.O. Box 55, Kumba, Cameroon. jatojatoisaac@yahoo.com., Datchoua-Poutcheu FR; Parasite and Vectors Research Unit, Department of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon. fabriceroberto@yahoo.fr.; Research Foundation for Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon. fabriceroberto@yahoo.fr., Kah E; Parasite and Vectors Research Unit, Department of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon. kah_elvis@yahoo.fr.; Department of Geography, University of Yaounde1, Yaounde, Cameroon. kah_elvis@yahoo.fr., Enyong P; Parasite and Vectors Research Unit, Department of Microbiology and Parasitology, University of Buea, P.O. Box 63, Buea, Cameroon. enyongap@gmail.com.; Tropical Medicine Research station, P.O. Box 55, Kumba, Cameroon. enyongap@gmail.com., Taylor DW; Division of Pathway Medicine, School for Biomedical Studies, University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK. David.W.Taylor@ed.ac.uk.
المصدر: Parasites & vectors [Parasit Vectors] 2015 Apr 02; Vol. 8, pp. 202. Date of Electronic Publication: 2015 Apr 02.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101462774 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-3305 (Electronic) Linking ISSN: 17563305 NLM ISO Abbreviation: Parasit Vectors Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central
مواضيع طبية MeSH: Disease Transmission, Infectious/*prevention & control , Insecticides/*administration & dosage , Ivermectin/*administration & dosage , Onchocerciasis/*epidemiology , Onchocerciasis/*prevention & control , Simuliidae/*growth & development , Simuliidae/*parasitology, Animals ; Cameroon/epidemiology ; Feeding Behavior ; Humans ; Onchocerca/isolation & purification ; Prevalence ; Rainforest
مستخلص: Background: Community-Directed Treatment with Ivermectin (CDTI) is the main strategy adopted by the African Programme for Onchocerciasis control (APOC). Recent reports from onchocerciasis endemic areas of savannah zones have demonstrated the feasibility of disease elimination through CDTI. Such information is lacking in rain forest zones. In this study, we investigated the parasitological and entomological indices of onchocerciasis transmission in three drainage basins in the rain forest area of Cameroon [after over a decade of CDTI]. River basins differed in terms of river number and their flow rates; and were characterized by high pre-control prevalence rates (60-98%).
Methods: Nodule palpation and skin snipping were carried out in the study communities to determine the nodule rates, microfilarial prevalences and intensity. Simulium flies were caught at capture points and dissected to determine the biting, parous, infection and infective rates and the transmission potential.
Results: The highest mean microfilaria (mf) prevalence was recorded in the Meme (52.7%), followed by Mungo (41.0%) and Manyu drainage basin (33.0%). The same trend was seen with nodule prevalence between the drainage basins. Twenty-three (23/39) communities (among which 13 in the Meme) still had mf prevalence above 40%. All the communities surveyed had community microfilarial loads (CMFL) below 10 mf/skin snip (ss). The infection was more intense in the Mungo and Meme. The intensity of infection was still high in younger individuals and children less than 10 years of age. Transmission potentials as high as 1211.7 infective larvae/person/month were found in some of the study communities. Entomological indices followed the same trend as the parasitological indices in the three river basins with the Meme having the highest values.
Conclusion: When compared with pre-control data, results of the present study show that after over a decade of CDTI, the burden of onchocerciasis has reduced. However, transmission is still going on in this study site where loiasis and onchocerciasis are co-endemic and where ecological factors strongly favour the onchocerciasis transmission. The possible reasons for this persistent and differential transmission despite over a decade of control efforts using ivermectin are discussed.
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معلومات مُعتمدة: 100715 United Kingdom Wellcome Trust
المشرفين على المادة: 0 (Insecticides)
70288-86-7 (Ivermectin)
تواريخ الأحداث: Date Created: 20150418 Date Completed: 20160104 Latest Revision: 20220318
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4393872
DOI: 10.1186/s13071-015-0817-2
PMID: 25886166
قاعدة البيانات: MEDLINE
الوصف
تدمد:1756-3305
DOI:10.1186/s13071-015-0817-2