دورية أكاديمية
Genital inflammation and the risk of HIV acquisition in women.
| العنوان: | Genital inflammation and the risk of HIV acquisition in women. |
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| المؤلفون: | Masson L; Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, University of Cape Town., Passmore JA; Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, University of Cape Town National Health Laboratory Services, Cape Town, South Africa., Liebenberg LJ; Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban., Werner L; Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban., Baxter C; Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban., Arnold KB; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge., Williamson C; Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, University of Cape Town., Little F; Department of Statistical Sciences, University of Cape Town., Mansoor LE; Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban., Naranbhai V; Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban., Lauffenburger DA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge., Ronacher K; National Research Foundation of South Africa/Department of Science and Technology Centre of Excellence for TB Biomedical Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, South Africa., Walzl G; National Research Foundation of South Africa/Department of Science and Technology Centre of Excellence for TB Biomedical Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, South Africa., Garrett NJ; Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban., Williams BL; Center for Infection and Immunity., Couto-Rodriguez M; Center for Infection and Immunity., Hornig M; Center for Infection and Immunity., Lipkin WI; Center for Infection and Immunity., Grobler A; Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban., Abdool Karim Q; Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York., Abdool Karim SS; Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York. |
| المصدر: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2015 Jul 15; Vol. 61 (2), pp. 260-9. Date of Electronic Publication: 2015 Apr 21. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: Chicago, IL : The University of Chicago Press, c1992- |
| مواضيع طبية MeSH: | Chemokines/*analysis , Cytokines/*analysis , Genital Diseases, Female/*diagnosis , Genitalia, Female/*immunology , Genitalia, Female/*virology , HIV Infections/*immunology , HIV Infections/*transmission, Africa ; Cervix Uteri/immunology ; Chemokine CCL2/analysis ; Chemokine CCL2/blood ; Chemokine CCL2/immunology ; Chemokines/blood ; Chemokines/genetics ; Chemokines/immunology ; Cytokines/blood ; Cytokines/genetics ; Cytokines/immunology ; Disease Susceptibility ; Female ; HIV Infections/virology ; Humans ; Inflammation/diagnosis ; Interferon-gamma/analysis ; Interferon-gamma/blood ; Interferon-gamma/immunology ; Interleukin-10/analysis ; Interleukin-10/immunology ; Interleukin-6/analysis ; Interleukin-6/blood ; Interleukin-6/immunology ; Interleukin-8/analysis ; Interleukin-8/blood ; Interleukin-8/immunology ; Sexually Transmitted Diseases ; South Africa ; Tumor Necrosis Factor-alpha/analysis ; Tumor Necrosis Factor-alpha/blood ; Tumor Necrosis Factor-alpha/immunology ; Uterine Cervicitis/diagnosis ; Vagina/immunology ; Vaginal Douching ; Vaginitis/diagnosis ; Young Adult |
| مستخلص: | Background: Women in Africa, especially young women, have very high human immunodeficiency virus (HIV) incidence rates that cannot be fully explained by behavioral risks. We investigated whether genital inflammation influenced HIV acquisition in this group. Methods: Twelve selected cytokines, including 9 inflammatory cytokines and chemokines (interleukin [IL]-1α, IL-1β, IL-6, tumor necrosis factor-α, IL-8, interferon-γ inducible protein-10 [IP-10], monocyte chemoattractant protein-1, macrophage inflammatory protein [MIP]-1α, MIP-1β), hematopoietic IL-7, and granulocyte macrophage colony-stimulating factor, and regulatory IL-10 were measured prior to HIV infection in cervicovaginal lavages from 58 HIV seroconverters and 58 matched uninfected controls and in plasma from a subset of 107 of these women from the Centre for the AIDS Programme of Research in South Africa 004 tenofovir gel trial. Results: HIV seroconversion was associated with raised genital inflammatory cytokines (including chemokines MIP-1α, MIP-1β, and IP-10). The risk of HIV acquisition was significantly higher in women with evidence of genital inflammation, defined by at least 5 of 9 inflammatory cytokines being raised (odds ratio, 3.2; 95% confidence interval, 1.3-7.9; P = .014). Genital cytokine concentrations were persistently raised (for about 1 year before infection), with no readily identifiable cause despite extensive investigation of several potential factors, including sexually transmitted infections and systemic cytokines. Conclusions: Elevated genital concentrations of HIV target cell-recruiting chemokines and a genital inflammatory profile contributes to the high risk of HIV acquisition in these African women. (© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.) |
| التعليقات: | Comment in: Clin Infect Dis. 2016 Jan 15;62(2):265-6. doi: 10.1093/cid/civ842. (PMID: 26394671) |
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| معلومات مُعتمدة: | U19-AI0859 United States AI NIAID NIH HHS; AI51794 United States AI NIAID NIH HHS; U19 AI051794 United States AI NIAID NIH HHS; United Kingdom WT_ Wellcome Trust; Z01 AI000859 United States ImNIH Intramural NIH HHS |
| فهرسة مساهمة: | Keywords: HIV transmission; cytokine; female genital tract; inflammation |
| المشرفين على المادة: | 0 (CCL2 protein, human) 0 (Chemokine CCL2) 0 (Chemokines) 0 (Cytokines) 0 (IL10 protein, human) 0 (Interleukin-6) 0 (Interleukin-8) 0 (TNF protein, human) 0 (Tumor Necrosis Factor-alpha) 130068-27-8 (Interleukin-10) 82115-62-6 (Interferon-gamma) |
| تواريخ الأحداث: | Date Created: 20150423 Date Completed: 20160415 Latest Revision: 20240709 |
| رمز التحديث: | 20240709 |
| مُعرف محوري في PubMed: | PMC4565995 |
| DOI: | 10.1093/cid/civ298 |
| PMID: | 25900168 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6591 |
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| DOI: | 10.1093/cid/civ298 |