دورية أكاديمية
Gold nanoparticles and/or N-acetylcysteine mediate carrageenan-induced inflammation and oxidative stress in a concentration-dependent manner.
| العنوان: | Gold nanoparticles and/or N-acetylcysteine mediate carrageenan-induced inflammation and oxidative stress in a concentration-dependent manner. |
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| المؤلفون: | Paula MM; Laboratório De Síntese De Complexos Multifuncionais, Programa De Pós-Graduação Em Ciência E Engenharia De Materiais, Universidade Do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil., Petronilho F; Laboratório De Fisiopatologia Clinica E Experimental, Programa De Pós-Graduação Em Ciências Da Saúde, Universidade Do Sul De Santa Catarina, Tubarão, Santa Catarina, Brazil., Vuolo F; Laboratório De Fisiopatologia Experimental, Programa De Pós-Graduação Em Ciências Da Saúde, Universidade Do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil., Ferreira GK; Laboratório De Síntese De Complexos Multifuncionais, Programa De Pós-Graduação Em Ciência E Engenharia De Materiais, Universidade Do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil., De Costa L; Laboratório De Síntese De Complexos Multifuncionais, Programa De Pós-Graduação Em Ciência E Engenharia De Materiais, Universidade Do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil., Santos GP; Laboratory of Physiology and Biochemistry of Exercise, Post-Graduate Program in Health Sciences, Health Sciences Unit, Universidade Do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil., Effting PS; Laboratory of Physiology and Biochemistry of Exercise, Post-Graduate Program in Health Sciences, Health Sciences Unit, Universidade Do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil., Dal-Pizzol F; Laboratório De Fisiopatologia Experimental, Programa De Pós-Graduação Em Ciências Da Saúde, Universidade Do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil., Dal-Bó AG; Laboratório De Síntese De Complexos Multifuncionais, Programa De Pós-Graduação Em Ciência E Engenharia De Materiais, Universidade Do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil., Frizon TE; Laboratório De Síntese De Complexos Multifuncionais, Programa De Pós-Graduação Em Ciência E Engenharia De Materiais, Universidade Do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil., Silveira PC; Laboratory of Physiology and Biochemistry of Exercise, Post-Graduate Program in Health Sciences, Health Sciences Unit, Universidade Do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil., Pinho RA; Laboratory of Physiology and Biochemistry of Exercise, Post-Graduate Program in Health Sciences, Health Sciences Unit, Universidade Do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil. |
| المصدر: | Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2015 Oct; Vol. 103 (10), pp. 3323-30. Date of Electronic Publication: 2015 Apr 28. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101234237 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4965 (Electronic) Linking ISSN: 15493296 NLM ISO Abbreviation: J Biomed Mater Res A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Hoboken, NJ : John Wiley & Sons, c2002- |
| مواضيع طبية MeSH: | Acetylcysteine*/chemistry , Acetylcysteine*/pharmacology, Carrageenan/*adverse effects , Gold/*chemistry , Metal Nanoparticles/*chemistry , Oxidative Stress/*drug effects, Animals ; Carrageenan/pharmacology ; Dose-Response Relationship, Drug ; Inflammation/chemically induced ; Inflammation/metabolism ; Inflammation/pathology ; Interleukin-10/metabolism ; Interleukin-1beta/metabolism ; Male ; Peroxidase/metabolism ; Rats ; Rats, Wistar ; Tumor Necrosis Factor-alpha/metabolism |
| مستخلص: | We report the effect of gold nanoparticles (AuNP) in an acute inflammation model induced by carrageenan (CG) and compared this effect with those induced by the antioxidant N-acetylcysteine (NAC) alone and by the synergistic effect of NAC and AuNP together. Male Wistar rats received saline or saline containing CG administered into the pleural cavity, and some rats also received NAC (20 mg/kg) subcutaneously and/or AuNP administered into the pleural cavity immediately after surgery. Four hours later, the rats were sacrificed and pleural exudates obtained for evaluation of cytokine levels and myeloperoxidase activities. Oxidative stress parameters were also evaluated in the lungs. The results demonstrated that the inflammatory process caused by the administration of CG into the pleural cavity resulted in a substantial increase in the levels of tumor necrosis factor-α, interleukin-1β, and myeloperoxidase and a reduction in interleukin-10 levels. These levels seem to be reversed after different treatments in animals. Antioxidant enzymes exhibited positive responses after treatment of NAC + AuNP, and all treatments were effective at reducing lipid peroxidation and oxidation of thiol groups induced by CG. These findings suggest that small compounds, such as NAC plus AuNP, may be useful in the treatment of conditions associated with local inflammation. (© 2015 Wiley Periodicals, Inc.) |
| فهرسة مساهمة: | Keywords: carrageenan; gold nanoparticles; inflammation; oxidative stress; pleurisy |
| المشرفين على المادة: | 0 (IL1B protein, rat) 0 (Interleukin-1beta) 0 (Tumor Necrosis Factor-alpha) 130068-27-8 (Interleukin-10) 7440-57-5 (Gold) 9000-07-1 (Carrageenan) EC 1.11.1.7 (Peroxidase) WYQ7N0BPYC (Acetylcysteine) |
| تواريخ الأحداث: | Date Created: 20150429 Date Completed: 20160525 Latest Revision: 20150828 |
| رمز التحديث: | 20230127 |
| DOI: | 10.1002/jbm.a.35469 |
| PMID: | 25917538 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1552-4965 |
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| DOI: | 10.1002/jbm.a.35469 |