دورية أكاديمية
Inner workings and biological impact of phospholipid flippases.
| العنوان: | Inner workings and biological impact of phospholipid flippases. |
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| المؤلفون: | Panatala R; Department of Membrane Enzymology, Bijvoet Center and Institute of Biomembranes, Utrecht University, 3584 Utrecht, The Netherlands Molecular Cell Biology Division, University of Osnabrück, 49076 Osnabrück, Germany., Hennrich H; Department of Membrane Enzymology, Bijvoet Center and Institute of Biomembranes, Utrecht University, 3584 Utrecht, The Netherlands., Holthuis JC; Department of Membrane Enzymology, Bijvoet Center and Institute of Biomembranes, Utrecht University, 3584 Utrecht, The Netherlands Molecular Cell Biology Division, University of Osnabrück, 49076 Osnabrück, Germany holthuis@uos.de. |
| المصدر: | Journal of cell science [J Cell Sci] 2015 Jun 01; Vol. 128 (11), pp. 2021-32. Date of Electronic Publication: 2015 Apr 27. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Company of Biologists Country of Publication: England NLM ID: 0052457 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9137 (Electronic) Linking ISSN: 00219533 NLM ISO Abbreviation: J Cell Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge : Company of Biologists Original Publication: London. |
| مواضيع طبية MeSH: | Phospholipid Transfer Proteins/*metabolism , Phospholipids/*metabolism, Animals ; Cell Membrane/metabolism ; Endosomes/metabolism ; Humans ; trans-Golgi Network/metabolism |
| مستخلص: | The plasma membrane, trans-Golgi network and endosomal system of eukaryotic cells are populated with flippases that hydrolyze ATP to help establish asymmetric phospholipid distributions across the bilayer. Upholding phospholipid asymmetry is vital to a host of cellular processes, including membrane homeostasis, vesicle biogenesis, cell signaling, morphogenesis and migration. Consequently, defining the identity of flippases and their biological impact has been the subject of intense investigations. Recent work has revealed a remarkable degree of kinship between flippases and cation pumps. In this Commentary, we review emerging insights into how flippases work, how their activity is controlled according to cellular demands, and how disrupting flippase activity causes system failure of membrane function, culminating in membrane trafficking defects, aberrant signaling and disease. (© 2015. Published by The Company of Biologists Ltd.) |
| فهرسة مساهمة: | Keywords: Flippase; Golgi complex; Lipid asymmetry; P-type ATPase; Phosphatidylserine; Vesicular transport |
| المشرفين على المادة: | 0 (Phospholipid Transfer Proteins) 0 (Phospholipids) |
| تواريخ الأحداث: | Date Created: 20150429 Date Completed: 20160317 Latest Revision: 20150602 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1242/jcs.102715 |
| PMID: | 25918123 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1477-9137 |
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| DOI: | 10.1242/jcs.102715 |