دورية أكاديمية
Lipoprotein apheresis in patients with peripheral artery disease and hyperlipoproteinemia(a).
| العنوان: | Lipoprotein apheresis in patients with peripheral artery disease and hyperlipoproteinemia(a). |
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| المؤلفون: | Poller WC; Klinik für Kardiologie und Angiologie, Campus Mitte, Charité - Universitätsmedizin Berlin, Germany., Dreger H; Klinik für Kardiologie und Angiologie, Campus Mitte, Charité - Universitätsmedizin Berlin, Germany., Morgera S; Schwerpunktpraxis für Nieren- und Hochdruckkrankheiten Berlin, Germany., Berger A; HELIOS Klinikum Emil von Behring, Klinik für Gefäßmedizin, Berlin, Germany., Flessenkämper I; HELIOS Klinikum Emil von Behring, Klinik für Gefäßmedizin, Berlin, Germany., Enke-Melzer K; HELIOS Klinikum Emil von Behring, Klinik für Gefäßmedizin, Berlin, Germany. Electronic address: kathrin.enke-melzer@helios-kliniken.de. |
| المصدر: | Atherosclerosis. Supplements [Atheroscler Suppl] 2015 May; Vol. 18, pp. 187-93. |
| نوع المنشور: | Journal Article; Observational Study; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100973461 Publication Model: Print Cited Medium: Internet ISSN: 1878-5050 (Electronic) Linking ISSN: 15675688 NLM ISO Abbreviation: Atheroscler Suppl Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier Science, 2000- |
| مواضيع طبية MeSH: | Blood Component Removal/*methods , Hyperlipoproteinemias/*therapy , Lipoprotein(a)/*blood , Peripheral Arterial Disease/*surgery, Ankle Brachial Index ; Biomarkers/blood ; Blood Gas Monitoring, Transcutaneous ; Exercise Test ; Exercise Tolerance ; Female ; Germany ; Hemodynamics ; Humans ; Hyperlipoproteinemias/blood ; Hyperlipoproteinemias/complications ; Hyperlipoproteinemias/diagnosis ; Male ; Microcirculation ; Middle Aged ; Pain Measurement ; Peripheral Arterial Disease/complications ; Peripheral Arterial Disease/diagnosis ; Peripheral Arterial Disease/physiopathology ; Predictive Value of Tests ; Prospective Studies ; Recovery of Function ; Registries ; Risk Factors ; Severity of Illness Index ; Time Factors ; Treatment Outcome |
| مستخلص: | Objective: Hyperlipoproteinemia(a) [Lp(a)-HLP] is a major risk factor for severe atherosclerosis. The present investigation sought to assess the effect of lipoprotein apheresis (LA) in patients with peripheral artery disease (PAD) and Lp(a)-HLP. Methods: In January 2013, we started a registry for Lp(a)-HLP patients who receive weekly LA in our center. So far, ten patients with severe PAD and isolated Lp(a)-HLP who recently underwent revascularization (index procedure) have been included. Pain level, ankle-brachial-index (ABI), transcutaneous oxygen pressure (tcpO2) and walking distance were determined before, as well as 1, 3, 6 and 12 months after initiation of LA. Furthermore, the mean time interval between revascularizations within the 12 months prior to the index procedure and up to 12 months after the index procedure was assessed. Results: All analyzed parameters significantly improved under LA. When comparing the results before LA with the results after 12 months, the ankle-brachial-index increased from 0.5 ± 0.2 to 0.9 ± 0.1 (P < 0.001). The tcpO2 levels also increased from 42.9 ± 2.3 mmHg to 59.0 ± 8.9 mmHg (P < 0.001). The improved microcirculation was associated with a reduction of the mean pain level from 7.0 ± 1.5 to 2.0 ± 0.8 (P < 0.001) as determined using the visual analog scale. The walking distance increased from 87 ± 60 m to 313 ± 145 m (P < 0.001). Importantly, the frequency of revascularization procedures was strongly decreased under LA. All patients combined underwent 35 revascularizations within the 12 months prior to the index procedure (mean interval between two revascularizations: 104.3 days). Since the index procedure, only one revascularization was necessary within 79 patient-months under LA (mean interval: 2404.5 days, P < 0.001). Conclusion: LA improves circulation, oxygen supply, level of pain and walking distance in patients with severe PAD and Lp(a)-HLP. The frequency of revascularization procedures is strongly reduced under LA treatment. (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Hyperlipoproteinemia(a); Lipoprotein apheresis; Lipoprotein(a); Peripheral artery disease |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Lipoprotein(a)) |
| تواريخ الأحداث: | Date Created: 20150505 Date Completed: 20160203 Latest Revision: 20150504 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.atherosclerosissup.2015.02.032 |
| PMID: | 25936325 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-5050 |
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| DOI: | 10.1016/j.atherosclerosissup.2015.02.032 |