دورية أكاديمية
أعرض في EDS

Dissecting the calcium-induced differentiation of human primary keratinocytes stem cells by integrative and structural network analyses.

التفاصيل البيبلوغرافية
العنوان: Dissecting the calcium-induced differentiation of human primary keratinocytes stem cells by integrative and structural network analyses.
المؤلفون: Toufighi K; EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain., Yang JS; EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain., Luis NM; EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain., Aznar Benitah S; EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Institute for Research in Biomedicine, Parc Científic de Barcelona, Barcelona, Spain., Lehner B; EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain., Serrano L; EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain., Kiel C; EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain.
المصدر: PLoS computational biology [PLoS Comput Biol] 2015 May 06; Vol. 11 (5), pp. e1004256. Date of Electronic Publication: 2015 May 06 (Print Publication: 2015).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7358 (Electronic) Linking ISSN: 1553734X NLM ISO Abbreviation: PLoS Comput Biol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science, [2005]-
مواضيع طبية MeSH: Calcium/*chemistry , Computational Biology/*methods , Keratinocytes/*cytology , Stem Cells/*cytology, Cell Differentiation ; Cluster Analysis ; Epidermal Cells ; Gene Expression Profiling ; Humans ; Models, Statistical ; NF-kappa B/metabolism ; Oligonucleotide Array Sequence Analysis ; Protein Interaction Mapping ; Signal Transduction ; Software ; Transcriptome ; Tumor Necrosis Factor-alpha/metabolism
مستخلص: The molecular details underlying the time-dependent assembly of protein complexes in cellular networks, such as those that occur during differentiation, are largely unexplored. Focusing on the calcium-induced differentiation of primary human keratinocytes as a model system for a major cellular reorganization process, we look at the expression of genes whose products are involved in manually-annotated protein complexes. Clustering analyses revealed only moderate co-expression of functionally related proteins during differentiation. However, when we looked at protein complexes, we found that the majority (55%) are composed of non-dynamic and dynamic gene products ('di-chromatic'), 19% are non-dynamic, and 26% only dynamic. Considering three-dimensional protein structures to predict steric interactions, we found that proteins encoded by dynamic genes frequently interact with a common non-dynamic protein in a mutually exclusive fashion. This suggests that during differentiation, complex assemblies may also change through variation in the abundance of proteins that compete for binding to common proteins as found in some cases for paralogous proteins. Considering the example of the TNF-α/NFκB signaling complex, we suggest that the same core complex can guide signals into diverse context-specific outputs by addition of time specific expressed subunits, while keeping other cellular functions constant. Thus, our analysis provides evidence that complex assembly with stable core components and competition could contribute to cell differentiation.
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معلومات مُعتمدة: 13-1064 United Kingdom AICR_ Worldwide Cancer Research
المشرفين على المادة: 0 (NF-kappa B)
0 (Tumor Necrosis Factor-alpha)
SY7Q814VUP (Calcium)
تواريخ الأحداث: Date Created: 20150507 Date Completed: 20160222 Latest Revision: 20220129
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4422705
DOI: 10.1371/journal.pcbi.1004256
PMID: 25946651
قاعدة البيانات: MEDLINE
الوصف
تدمد:1553-7358
DOI:10.1371/journal.pcbi.1004256