دورية أكاديمية
Increased expression of neuropilin 1 in melanoma progression and its prognostic significance in patients with melanoma.
العنوان: | Increased expression of neuropilin 1 in melanoma progression and its prognostic significance in patients with melanoma. |
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المؤلفون: | Lu J; Department of Dermatology and Skin Science, Research Pavilion, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC V5Z IL8, Canada., Cheng Y; Department of Dermatology and Skin Science, Research Pavilion, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC V5Z IL8, Canada., Zhang G; Department of Dermatology and Skin Science, Research Pavilion, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC V5Z IL8, Canada., Tang Y; Department of Dermatology and Skin Science, Research Pavilion, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC V5Z IL8, Canada., Dong Z; Department of Pathophysiology, Basic Medical College, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China., McElwee KJ; Department of Dermatology and Skin Science, Research Pavilion, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC V5Z IL8, Canada., Li G; Department of Dermatology and Skin Science, Research Pavilion, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC V5Z IL8, Canada. |
المصدر: | Molecular medicine reports [Mol Med Rep] 2015 Aug; Vol. 12 (2), pp. 2668-76. Date of Electronic Publication: 2015 May 07. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-3004 (Electronic) Linking ISSN: 17912997 NLM ISO Abbreviation: Mol Med Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Athens, Greece : D. A. Spandidos |
مواضيع طبية MeSH: | Melanoma/*diagnosis , Neuropilin-1/*analysis , Skin/*pathology , Skin Neoplasms/*diagnosis, Biomarkers, Tumor/analysis ; Biomarkers, Tumor/biosynthesis ; Disease Progression ; Female ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Male ; Matrix Metalloproteinase 2/analysis ; Melanoma/pathology ; Middle Aged ; Prognosis ; Skin Neoplasms/pathology ; Tissue Array Analysis ; Up-Regulation |
مستخلص: | Neuropilin 1 (NRP1), a receptor of vascular endothelial growth factor (VEGF), promotes angiogenesis, tumor growth, tumor invasion and metastasis. However, the function of NRP1 in melanoma progression, as well as the effect of NRP1 expression on the prognosis of patients with melanoma remains unknown. In the present study, NRP1 expression was examined in 460 cases of melanocytic lesions (28 common nevi, 51 dysplastic nevi, 250 primary melanoma and 131 metastatic melanoma) at different stages, using a tissue microarray. The correlation of NRP1 expression with melanoma progression, and its prognostic value in patients with melanoma was examined. In addition, the correlation between matrix metalloproteinase 2 (MMP2) and NRP1 expression in patients with melanoma was analyzed. The results demonstrated that NRP1 expression was significantly increased in primary (56%) and metastatic melanoma (62%), compared with common nevi (11%) and dysplastic nevi (24%). Notably, increased NRP1 expression was correlated with a poorer overall, and disease-specific, 10-year survival (P=0.03 and P=0.002, respectively). Multivariate Cox regression analyses indicated that NRP1 is an independent prognostic marker for melanoma. Furthermore, a significant positive correlation between NRP1 and MMP2 expression in melanoma biopsies was observed, and their concomitant expression was closely correlated with melanoma patient survival, further supporting the hypothesis that the expression of NRP1 is associated with melanoma invasion and metastasis. In conclusion, increased NRP1 expression is associated with disease progression and reduced survival in patients with melanoma, and is a promising prognostic molecular marker for this disease. |
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معلومات مُعتمدة: | CCI‑117958 Canada Canadian Institutes of Health Research |
المشرفين على المادة: | 0 (Biomarkers, Tumor) 144713-63-3 (Neuropilin-1) EC 3.4.24.24 (Matrix Metalloproteinase 2) |
تواريخ الأحداث: | Date Created: 20150509 Date Completed: 20160310 Latest Revision: 20181113 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC4464456 |
DOI: | 10.3892/mmr.2015.3752 |
PMID: | 25954957 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1791-3004 |
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DOI: | 10.3892/mmr.2015.3752 |