دورية أكاديمية
أعرض في EDS

Vasorelaxant and Hypotensive Effects of Jaboticaba Fruit (Myrciaria cauliflora) Extract in Rats.

التفاصيل البيبلوغرافية
العنوان: Vasorelaxant and Hypotensive Effects of Jaboticaba Fruit (Myrciaria cauliflora) Extract in Rats.
المؤلفون: Lobo de Andrade DM; Faculty of Pharmacy, Federal University of Goias, Rua 240, Esquina com 5 Avenida, s/n, 74605-170 Goiânia, GO, Brazil., Reis Cde F; Faculty of Pharmacy, Federal University of Goias, Rua 240, Esquina com 5 Avenida, s/n, 74605-170 Goiânia, GO, Brazil., Castro PF; Faculty of Pharmacy, Federal University of Goias, Rua 240, Esquina com 5 Avenida, s/n, 74605-170 Goiânia, GO, Brazil., Borges LL; Faculty of Pharmacy, Federal University of Goias, Rua 240, Esquina com 5 Avenida, s/n, 74605-170 Goiânia, GO, Brazil., Amaral NO; Center for Neuroscience and Cardiovascular Research, Biological Sciences Institute, Federal University of Goias, Campus Samambaia, 74001-970 Goiânia, GO, Brazil., Torres IM; Faculty of Pharmacy, Federal University of Goias, Rua 240, Esquina com 5 Avenida, s/n, 74605-170 Goiânia, GO, Brazil., Rezende SG; Faculty of Pharmacy, Federal University of Goias, Rua 240, Esquina com 5 Avenida, s/n, 74605-170 Goiânia, GO, Brazil., Gil Ede S; Faculty of Pharmacy, Federal University of Goias, Rua 240, Esquina com 5 Avenida, s/n, 74605-170 Goiânia, GO, Brazil., Cardoso da Conceição E; Faculty of Pharmacy, Federal University of Goias, Rua 240, Esquina com 5 Avenida, s/n, 74605-170 Goiânia, GO, Brazil., Pedrino GR; Center for Neuroscience and Cardiovascular Research, Biological Sciences Institute, Federal University of Goias, Campus Samambaia, 74001-970 Goiânia, GO, Brazil., Lavorenti Rocha M; Faculty of Pharmacy, Federal University of Goias, Rua 240, Esquina com 5 Avenida, s/n, 74605-170 Goiânia, GO, Brazil.
المصدر: Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2015; Vol. 2015, pp. 696135. Date of Electronic Publication: 2015 Apr 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub Country of Publication: United States NLM ID: 101215021 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1741-427X (Print) Linking ISSN: 1741427X NLM ISO Abbreviation: Evid Based Complement Alternat Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2011- : New York, NY : Hindawi Pub.
Original Publication: Oxford, UK : Oxford University Press, c2004-
مستخلص: This study's aim was to determine the effect of hydroalcoholic extract of M. cauliflora (HEMC) on vascular tension and blood pressure in rats. In our in vitro studies using precontracted isolated aortas from rats, HEMC and acetylcholine (positive control) induced relaxation only in vessels with endothelium. Pretreatment with L-NAME (NO synthase inhibitor) or ODQ (soluble guanylyl cyclase (sGC) inhibitor) abolished the HEMC-induced relaxation. The treatment with MDL-12,330A (adenylyl cyclase (AC) inhibitor) or diclofenac (COX inhibitor) reduced HEMC-induced vasorelaxation. The blockade of muscarinic and β-adrenergic receptors (by atropine and propranolol, resp.) did not promote changes in HEMC-induced vasorelaxation. In our in vivo studies, catheters were inserted into the right femoral vein and artery of anesthetized rats for HEMC infusion and the measurement of blood pressure, heart rate, and aortic blood flow. The intravenous infusion of HEMC produced hypotension and increased aortic blood flow with no changes in heart rate. These findings showed that HEMC induces endothelium-dependent vascular relaxation and hypotension with no alteration in heart rate. The NO/sGC/cGMP pathway seems to be the main cellular route involved in the vascular responsiveness.
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تواريخ الأحداث: Date Created: 20150512 Date Completed: 20150511 Latest Revision: 20220310
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4413038
DOI: 10.1155/2015/696135
PMID: 25960756
قاعدة البيانات: MEDLINE
الوصف
تدمد:1741-427X
DOI:10.1155/2015/696135