دورية أكاديمية
Vasorelaxant and Hypotensive Effects of Jaboticaba Fruit (Myrciaria cauliflora) Extract in Rats.
العنوان: | Vasorelaxant and Hypotensive Effects of Jaboticaba Fruit (Myrciaria cauliflora) Extract in Rats. |
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المؤلفون: | Lobo de Andrade DM; Faculty of Pharmacy, Federal University of Goias, Rua 240, Esquina com 5 Avenida, s/n, 74605-170 Goiânia, GO, Brazil., Reis Cde F; Faculty of Pharmacy, Federal University of Goias, Rua 240, Esquina com 5 Avenida, s/n, 74605-170 Goiânia, GO, Brazil., Castro PF; Faculty of Pharmacy, Federal University of Goias, Rua 240, Esquina com 5 Avenida, s/n, 74605-170 Goiânia, GO, Brazil., Borges LL; Faculty of Pharmacy, Federal University of Goias, Rua 240, Esquina com 5 Avenida, s/n, 74605-170 Goiânia, GO, Brazil., Amaral NO; Center for Neuroscience and Cardiovascular Research, Biological Sciences Institute, Federal University of Goias, Campus Samambaia, 74001-970 Goiânia, GO, Brazil., Torres IM; Faculty of Pharmacy, Federal University of Goias, Rua 240, Esquina com 5 Avenida, s/n, 74605-170 Goiânia, GO, Brazil., Rezende SG; Faculty of Pharmacy, Federal University of Goias, Rua 240, Esquina com 5 Avenida, s/n, 74605-170 Goiânia, GO, Brazil., Gil Ede S; Faculty of Pharmacy, Federal University of Goias, Rua 240, Esquina com 5 Avenida, s/n, 74605-170 Goiânia, GO, Brazil., Cardoso da Conceição E; Faculty of Pharmacy, Federal University of Goias, Rua 240, Esquina com 5 Avenida, s/n, 74605-170 Goiânia, GO, Brazil., Pedrino GR; Center for Neuroscience and Cardiovascular Research, Biological Sciences Institute, Federal University of Goias, Campus Samambaia, 74001-970 Goiânia, GO, Brazil., Lavorenti Rocha M; Faculty of Pharmacy, Federal University of Goias, Rua 240, Esquina com 5 Avenida, s/n, 74605-170 Goiânia, GO, Brazil. |
المصدر: | Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2015; Vol. 2015, pp. 696135. Date of Electronic Publication: 2015 Apr 15. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Hindawi Pub Country of Publication: United States NLM ID: 101215021 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1741-427X (Print) Linking ISSN: 1741427X NLM ISO Abbreviation: Evid Based Complement Alternat Med Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Publication: 2011- : New York, NY : Hindawi Pub. Original Publication: Oxford, UK : Oxford University Press, c2004- |
مستخلص: | This study's aim was to determine the effect of hydroalcoholic extract of M. cauliflora (HEMC) on vascular tension and blood pressure in rats. In our in vitro studies using precontracted isolated aortas from rats, HEMC and acetylcholine (positive control) induced relaxation only in vessels with endothelium. Pretreatment with L-NAME (NO synthase inhibitor) or ODQ (soluble guanylyl cyclase (sGC) inhibitor) abolished the HEMC-induced relaxation. The treatment with MDL-12,330A (adenylyl cyclase (AC) inhibitor) or diclofenac (COX inhibitor) reduced HEMC-induced vasorelaxation. The blockade of muscarinic and β-adrenergic receptors (by atropine and propranolol, resp.) did not promote changes in HEMC-induced vasorelaxation. In our in vivo studies, catheters were inserted into the right femoral vein and artery of anesthetized rats for HEMC infusion and the measurement of blood pressure, heart rate, and aortic blood flow. The intravenous infusion of HEMC produced hypotension and increased aortic blood flow with no changes in heart rate. These findings showed that HEMC induces endothelium-dependent vascular relaxation and hypotension with no alteration in heart rate. The NO/sGC/cGMP pathway seems to be the main cellular route involved in the vascular responsiveness. |
References: | Am J Clin Nutr. 2008 Feb;87(2):323-31. (PMID: 18258621) Oecologia. 1987 Apr;72 (1):137-147. (PMID: 28312910) Arch Latinoam Nutr. 2008 Dec;58(4):416-21. (PMID: 19368305) Mol Aspects Med. 2010 Dec;31(6):513-39. (PMID: 20837052) J Agric Food Chem. 2012 Aug 1;60(30):7513-25. (PMID: 22809264) PLoS One. 2012;7(5):e37587. (PMID: 22629424) Prostaglandins Other Lipid Mediat. 2007 Jan;82(1-4):109-18. (PMID: 17164138) Nat Prod Res. 2010 May;24(9):873-98. (PMID: 20461632) Clin Exp Pharmacol Physiol. 2009 Dec;36(12):e83-9. (PMID: 19719753) Nature. 1980 Nov 27;288(5789):373-6. (PMID: 6253831) Br J Pharmacol. 1992 Nov;107(3):684-90. (PMID: 1335334) Oecologia. 1987 Apr;72 (1):148-156. (PMID: 28312911) Food Chem. 2008 Aug 15;109(4):883-890. (PMID: 21340048) N Engl J Med. 2008 Feb 7;358(6):615-24. (PMID: 18256396) Thromb Res. 1977 Sep;11(3):323-44. (PMID: 335560) Br J Pharmacol. 2006 Jan;147 Suppl 1:S252-7. (PMID: 16402111) J Med Food. 2014 Feb;17(2):262-7. (PMID: 24283277) Wien Klin Wochenschr. 1991;103(14):422-34. (PMID: 1926869) Br J Nutr. 2013 Aug 28;110(3):447-55. (PMID: 23415177) Crit Rev Food Sci Nutr. 2009 Mar;49(3):283-98. (PMID: 19093271) J Sci Food Agric. 2012 Jun;92(8):1679-87. (PMID: 22173652) J Med Food. 2010 Oct;13(5):1027-35. (PMID: 20626254) |
تواريخ الأحداث: | Date Created: 20150512 Date Completed: 20150511 Latest Revision: 20220310 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC4413038 |
DOI: | 10.1155/2015/696135 |
PMID: | 25960756 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1741-427X |
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DOI: | 10.1155/2015/696135 |