دورية أكاديمية
A probabilistic map of the human ventral sensorimotor cortex using electrical stimulation.
| العنوان: | A probabilistic map of the human ventral sensorimotor cortex using electrical stimulation. |
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| المؤلفون: | Breshears JD; Departments of 1 Neurological Surgery., Molinaro AM; Departments of 1 Neurological Surgery.; Epidemiology and Biostatistics, and., Chang EF; Departments of 1 Neurological Surgery.; Physiology, and.; Center for Integrative Neuroscience, University of California, San Francisco; and.; Center for Neural Engineering and Prostheses, University of California, Berkeley and San Francisco, California. |
| المصدر: | Journal of neurosurgery [J Neurosurg] 2015 Aug; Vol. 123 (2), pp. 340-9. Date of Electronic Publication: 2015 May 15. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association of Neurological Surgeons Country of Publication: United States NLM ID: 0253357 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1933-0693 (Electronic) Linking ISSN: 00223085 NLM ISO Abbreviation: J Neurosurg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Charlottesville, VA : American Association of Neurological Surgeons Original Publication: Chicago [etc.] |
| مواضيع طبية MeSH: | Electric Stimulation*, Brain Diseases/*surgery , Brain Mapping/*methods , Sensorimotor Cortex/*physiology, Adult ; Aged ; Brain Diseases/physiopathology ; Craniotomy ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Young Adult |
| مستخلص: | Object: The human ventral sensorimotor cortex (vSMC) is involved in facial expression, mastication, and swallowing, as well as the dynamic and highly coordinated movements of human speech production. However, vSMC organization remains poorly understood, and previously published population-driven maps of its somatotopy do not accurately reflect the variability across individuals in a quantitative, probabilistic fashion. The goal of this study was to describe the responses to electrical stimulation of the vSMC, generate probabilistic maps of function in the vSMC, and quantify the variability across individuals. Methods: Photographic, video, and stereotactic MRI data of intraoperative electrical stimulation of the vSMC were collected for 33 patients undergoing awake craniotomy. Stimulation sites were converted to a 2D coordinate system based on anatomical landmarks. Motor, sensory, and speech stimulation responses were reviewed and classified. Probabilistic maps of stimulation responses were generated, and spatial variance was quantified. Results: In 33 patients, the authors identified 194 motor, 212 sensory, 61 speech-arrest, and 27 mixed responses. Responses were complex, stereotyped, and mostly nonphysiological movements, involving hand, orofacial, and laryngeal musculature. Within individuals, the presence of oral movement representations varied; however, the dorsal-ventral order was always preserved. The most robust motor responses were jaw (probability 0.85), tongue (0.64), lips (0.58), and throat (0.52). Vocalizations were seen in 6 patients (0.18), more dorsally near lip and dorsal throat areas. Sensory responses were spatially dispersed; however, patients' subjective reports were highly precise in localization within the mouth. The most robust responses included tongue (0.82) and lips (0.42). The probability of speech arrest was 0.85, highest 15-20 mm anterior to the central sulcus and just dorsal to the sylvian fissure, in the anterior precentral gyrus or pars opercularis. Conclusions: The authors report probabilistic maps of function in the human vSMC based on intraoperative cortical electrical stimulation. These results define the expected range of mapping outcomes in the vSMC of a single individual and shed light on the functional organization of the vSMC supporting speech motor control and nonspeech functions. |
| معلومات مُعتمدة: | DP2-OD00862 United States OD NIH HHS; R00-NS065120 United States NS NINDS NIH HHS; R01-DC012379 United States DC NIDCD NIH HHS |
| فهرسة مساهمة: | Keywords: AIC = Akaike information criterion; AP = anterior-posterior; CN = cranial nerve; CS = central sulcus; DV = dorsal-ventral; ECS = electrocortical stimulation; ECoG = electrocorticography; MNI = Montreal Neurological Institute; SF = sylvian fissure; SMC = sensorimotor cortex; brain mapping; corticobulbar; dSMC = dorsal SMC; diagnostic and operative techniques; fMRI = functional MRI; probabilistic maps; sensorimotor cortex; vSMC = ventral SMC |
| تواريخ الأحداث: | Date Created: 20150516 Date Completed: 20151016 Latest Revision: 20220309 |
| رمز التحديث: | 20231215 |
| DOI: | 10.3171/2014.11.JNS14889 |
| PMID: | 25978714 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1933-0693 |
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| DOI: | 10.3171/2014.11.JNS14889 |