دورية أكاديمية
أعرض في EDS

The pluripotency factor NANOG promotes the formation of squamous cell carcinomas.

التفاصيل البيبلوغرافية
العنوان: The pluripotency factor NANOG promotes the formation of squamous cell carcinomas.
المؤلفون: Palla AR, Piazzolla D, Alcazar N, Cañamero M, Graña O, Gómez-López G, Dominguez O, Dueñas M; 1] Molecular Oncology Unit, CIEMAT, Madrid 28040, Spain [2] Oncogenomic Unit, Institute of Biomedical Research, University Hospital '12 de Octubre', Madrid 28040, Spain., Paramio JM; 1] Molecular Oncology Unit, CIEMAT, Madrid 28040, Spain [2] Oncogenomic Unit, Institute of Biomedical Research, University Hospital '12 de Octubre', Madrid 28040, Spain., Serrano M
المصدر: Scientific reports [Sci Rep] 2015 May 19; Vol. 5, pp. 10205. Date of Electronic Publication: 2015 May 19.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Carcinoma, Squamous Cell/*genetics , Epithelial-Mesenchymal Transition/*genetics , Homeodomain Proteins/*genetics , Papilloma/*genetics , Skin Neoplasms/*genetics, Animals ; Base Sequence ; Cell Line, Transformed ; Cell Proliferation/genetics ; Cell Transformation, Neoplastic/genetics ; DNA-Binding Proteins/genetics ; Gene Expression Regulation, Neoplastic ; Homeodomain Proteins/biosynthesis ; Humans ; Keratinocytes/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Nanog Homeobox Protein ; Neoplastic Stem Cells/pathology ; Papilloma/pathology ; Promoter Regions, Genetic/genetics ; Sequence Analysis, RNA ; Skin/metabolism ; Skin Neoplasms/pathology
مستخلص: NANOG is a key pluripotency factor in embryonic stem cells that is frequently expressed in squamous cell carcinomas (SCCs). However, a direct link between NANOG and SCCs remains to be established. Here, we show that inducible overexpression of NANOG in mouse skin epithelia favours the malignant conversion of skin papillomas induced by chemical carcinogenesis, leading to increased SCC formation. Gene expression analyses in pre-malignant skin indicate that NANOG induces genes associated to epithelial-mesenchymal transition (EMT). Some of these genes are directly activated by NANOG, including EMT-associated genes Zeb1, Zeb2, Twist1, Prrx1 and miR-21. Finally, endogenous NANOG binds to the promoters of theses genes in human SCC cells and, moreover, NANOG induces EMT features in primary keratinocytes. These results provide in vivo evidence for the oncogenic role of NANOG in squamous cell carcinomas.
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سلسلة جزيئية: GEO GSE56566
المشرفين على المادة: 0 (DNA-Binding Proteins)
0 (Homeodomain Proteins)
0 (Nanog Homeobox Protein)
0 (Nanog protein, mouse)
تواريخ الأحداث: Date Created: 20150520 Date Completed: 20160325 Latest Revision: 20181113
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4437308
DOI: 10.1038/srep10205
PMID: 25988972
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/srep10205