دورية أكاديمية
Prediagnostic Obesity and Physical Inactivity Are Associated with Shorter Telomere Length in Prostate Stromal Cells.
| العنوان: | Prediagnostic Obesity and Physical Inactivity Are Associated with Shorter Telomere Length in Prostate Stromal Cells. |
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| المؤلفون: | Joshu CE; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland. cjoshu1@jhu.edu., Peskoe SB; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Heaphy CM; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland. James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland., Kenfield SA; Department of Urology, University of California San Francisco, San Francisco, CA., Van Blarigan EL; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California., Mucci LA; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts. Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Giovannucci EL; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts. Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts., Stampfer MJ; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts. Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts., Yoon G; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Lee TK; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Hicks JL; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland., De Marzo AM; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland. James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland., Meeker AK; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland. James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland., Platz EA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland. James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland. |
| المصدر: | Cancer prevention research (Philadelphia, Pa.) [Cancer Prev Res (Phila)] 2015 Aug; Vol. 8 (8), pp. 737-42. Date of Electronic Publication: 2015 May 19. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101479409 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1940-6215 (Electronic) Linking ISSN: 19406215 NLM ISO Abbreviation: Cancer Prev Res (Phila) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia, PA : American Association for Cancer Research |
| مواضيع طبية MeSH: | Life Style*, Obesity/*physiopathology , Prostatic Neoplasms/*genetics , Prostatic Neoplasms/*pathology , Stromal Cells/*pathology , Telomere Shortening/*genetics, Adult ; Aged ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Prognosis ; Risk Factors ; Stromal Cells/metabolism ; Telomere Homeostasis/genetics ; Tissue Array Analysis |
| مستخلص: | Obesity and inactivity have been associated with advanced-stage prostate cancer, and poor prostate cancer outcomes, though the underlying mechanism(s) is unknown. To determine whether telomere shortening, which has been associated with lethal prostate cancer, may be a potential underlying mechanism, we prospectively evaluated the association between measures of adiposity, physical activity, and telomere length in 596 participants in the Health Professionals Follow-up Study, who were surgically treated for prostate cancer. Using tissue microarrays, we measured telomere length in cancer and benign cells using a telomere-specific FISH assay. Adiposity and activity were assessed via questionnaire within 2 years of diagnosis. Adjusting for age, pathologic stage, and grade, the median and SD of the per cell telomere signals were determined for each man for stromal cells and cancer cells by adiposity and activity categories. Overweight/obese men (54%) were similar to normal weight men on most factors, but had higher Gleason sum and lower activity levels. Overweight/obese men had 7.4% shorter telomeres in stromal cells than normal weight men (P = 0.06). The least active men had shorter telomeres in stromal cells than more active men (Ptrend = 0.002). Men who were overweight/obese and the least active had the shortest telomeres in stromal cells (20.7% shorter; P = 0.0005) compared with normal weight men who were the most active. Cancer cell telomere length and telomere length variability did not differ by measures of adiposity or activity. Telomere shortening in prostate cells may be one mechanism through which lifestyle influences prostate cancer risk and outcomes. (©2015 American Association for Cancer Research.) |
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| معلومات مُعتمدة: | CA133891 United States CA NCI NIH HHS; P50 CA058236 United States CA NCI NIH HHS; R01 CA072036 United States CA NCI NIH HHS; P01 CA055075 United States CA NCI NIH HHS; CA141298 United States CA NCI NIH HHS; CA55075 United States CA NCI NIH HHS; R01 CA133891 United States CA NCI NIH HHS; HL35464 United States HL NHLBI NIH HHS; P50 CA58236 United States CA NCI NIH HHS; UM1 CA167552 United States CA NCI NIH HHS; R01 HL035464 United States HL NHLBI NIH HHS; R01 CA141298 United States CA NCI NIH HHS |
| تواريخ الأحداث: | Date Created: 20150521 Date Completed: 20160505 Latest Revision: 20181113 |
| رمز التحديث: | 20240513 |
| مُعرف محوري في PubMed: | PMC4526348 |
| DOI: | 10.1158/1940-6207.CAPR-15-0097 |
| PMID: | 25990087 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1940-6215 |
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| DOI: | 10.1158/1940-6207.CAPR-15-0097 |