دورية أكاديمية
A new family of StART domain proteins at membrane contact sites has a role in ER-PM sterol transport.
العنوان: | A new family of StART domain proteins at membrane contact sites has a role in ER-PM sterol transport. |
---|---|
المؤلفون: | Gatta AT; Department of Cell Biology, UCL Institute of Ophthalmology, London, United Kingdom., Wong LH; Department of Cell Biology, UCL Institute of Ophthalmology, London, United Kingdom., Sere YY; Department of Biochemistry, Weill Cornell Medical College, New York, United States., Calderón-Noreña DM; Department of Biochemistry, Weill Cornell Medical College, New York, United States., Cockcroft S; Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom., Menon AK; Department of Biochemistry, Weill Cornell Medical College, New York, United States., Levine TP; Department of Cell Biology, UCL Institute of Ophthalmology, London, United Kingdom. |
المصدر: | ELife [Elife] 2015 May 22; Vol. 4. Date of Electronic Publication: 2015 May 22. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012- |
مواضيع طبية MeSH: | Carrier Proteins/*metabolism , Cell Membrane/*metabolism , Endoplasmic Reticulum/*metabolism , Mitochondrial Proteins/*metabolism , Saccharomyces cerevisiae Proteins/*metabolism , Sterols/*metabolism, Biological Transport/physiology ; Computational Biology ; HL-60 Cells ; Humans ; Plasmids/genetics ; Polymerase Chain Reaction |
مستخلص: | Sterol traffic between the endoplasmic reticulum (ER) and plasma membrane (PM) is a fundamental cellular process that occurs by a poorly understood non-vesicular mechanism. We identified a novel, evolutionarily diverse family of ER membrane proteins with StART-like lipid transfer domains and studied them in yeast. StART-like domains from Ysp2p and its paralog Lam4p specifically bind sterols, and Ysp2p, Lam4p and their homologs Ysp1p and Sip3p target punctate ER-PM contact sites distinct from those occupied by known ER-PM tethers. The activity of Ysp2p, reflected in amphotericin-sensitivity assays, requires its second StART-like domain to be positioned so that it can reach across ER-PM contacts. Absence of Ysp2p, Ysp1p or Sip3p reduces the rate at which exogenously supplied sterols traffic from the PM to the ER. Our data suggest that these StART-like proteins act in trans to mediate a step in sterol exchange between the PM and ER. |
References: | Annu Rev Biochem. 2009;78:827-56. (PMID: 19489735) Bioinformatics. 2010 Aug 15;26(16):1927-31. (PMID: 20554689) Biochim Biophys Acta. 2014 Oct;1842(10):1483-90. (PMID: 25066473) Elife. 2014;3. doi: 10.7554/eLife.02882. (PMID: 24920391) PLoS Biol. 2014 Oct;12(10):e1001969. (PMID: 25313861) BMC Biol. 2014;12:70. (PMID: 25159688) Traffic. 2015 Jan;16(1):1-18. (PMID: 25243850) Sci Rep. 2015;5:9685. (PMID: 25965669) J Cell Biol. 2009 Jun 29;185(7):1209-25. (PMID: 19564404) Cell. 2010 Dec 10;143(6):870-4. (PMID: 21145454) J Neurosci. 2011 Feb 9;31(6):2248-57. (PMID: 21307261) J Cell Biol. 2011 Apr 18;193(2):333-46. (PMID: 21502358) J Cell Biol. 2011 May 2;193(3):521-35. (PMID: 21518793) Traffic. 2011 Oct;12(10):1341-55. (PMID: 21689253) Mol Biol Cell. 2011 Nov;22(21):4004-15. (PMID: 21900492) Nat Methods. 2012 Feb;9(2):173-5. (PMID: 22198341) J Cell Sci. 2012 Jan 1;125(Pt 1):49-58. (PMID: 22250200) Methods Cell Biol. 2012;108:367-93. (PMID: 22325611) Nat Cell Biol. 2012 Jul;14(7):707-16. (PMID: 22729086) Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16882-7. (PMID: 23027975) Science. 2012 Nov 9;338(6108):815-8. (PMID: 23042293) Dev Cell. 2012 Dec 11;23(6):1129-40. (PMID: 23237950) Cell Rep. 2013 Feb 21;3(2):577-85. (PMID: 23416056) EMBO Rep. 2013 May;14(5):434-40. (PMID: 23519169) Biochim Biophys Acta. 2013 Nov;1833(11):2526-41. (PMID: 23380708) Nature. 2013 Sep 12;501(7466):257-61. (PMID: 23934110) PLoS Biol. 2013 Oct;11(10):e1001692. (PMID: 24204207) Cell. 2013 Nov 7;155(4):830-43. (PMID: 24209621) Antimicrob Agents Chemother. 2014;58(4):2409-14. (PMID: 24395234) J Biol Chem. 2014 Apr 11;289(15):10748-60. (PMID: 24569996) Nat Chem Biol. 2014 May;10(5):400-6. (PMID: 24681535) Nature. 2014 Jun 5;510(7503):48-57. (PMID: 24899304) J Cell Biol. 2014 Jun 23;205(6):759-69. (PMID: 24958771) Nature. 2014 Jun 26;510(7506):552-5. (PMID: 24847877) Nucleic Acids Res. 2009 Jul;37(Web Server issue):W492-7. (PMID: 19483096) Mol Biol Cell. 2009 Nov;20(22):4630-9. (PMID: 19776347) J Cell Biol. 2009 Dec 14;187(6):889-903. (PMID: 20008566) Eur Biophys J. 2010 Mar;39(4):565-78. (PMID: 20238256) Nat Genet. 2010 Aug;42(8):661-4. (PMID: 20639881) Mol Biol Cell. 2000 Jul;11(7):2445-57. (PMID: 10888680) Mol Cell. 2000 Jul;6(1):11-22. (PMID: 10949023) Science. 2000 Dec 1;290(5497):1721-6. (PMID: 11099405) Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2329-33. (PMID: 11226239) Eur J Biochem. 2001 Apr;268(8):2351-61. (PMID: 11298754) Mol Biol Cell. 2001 Jun;12(6):1633-44. (PMID: 11408574) EMBO J. 2003 May 1;22(9):2025-35. (PMID: 12727870) Syst Biol. 2003 Oct;52(5):696-704. (PMID: 14530136) Nature. 2003 Dec 18;426(6968):803-9. (PMID: 14685229) Biochem Cell Biol. 2004 Feb;82(1):87-98. (PMID: 15052330) J Biol Chem. 2004 Oct 22;279(43):45226-34. (PMID: 15316012) Cell. 1980 Aug;21(1):205-15. (PMID: 6996832) J Biol Chem. 1990 May 5;265(13):7248-56. (PMID: 2332429) Curr Opin Cell Biol. 1990 Aug;2(4):652-63. (PMID: 2252591) J Cell Biol. 1993 Sep;122(5):1013-22. (PMID: 8354691) EMBO J. 1993 Dec;12(12):4775-84. (PMID: 8223486) Nucleic Acids Res. 1994 Feb 25;22(4):597-603. (PMID: 8127709) J Bacteriol. 1998 Aug;180(16):4177-83. (PMID: 9696767) J Cell Biol. 2005 Jan 17;168(2):257-69. (PMID: 15657396) Nat Rev Mol Cell Biol. 2005 Mar;6(3):209-20. (PMID: 15738987) Biochemistry. 2005 Apr 19;44(15):5816-26. (PMID: 15823040) Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W244-8. (PMID: 15980461) Nature. 2005 Sep 1;437(7055):154-8. (PMID: 16136145) J Biol Chem. 2005 Dec 30;280(52):42627-35. (PMID: 16230336) J Cell Biol. 2006 Apr 10;173(1):107-19. (PMID: 16585271) J Cell Biol. 2006 Sep 11;174(6):803-13. (PMID: 16966422) Biochim Biophys Acta. 2006 Sep-Oct;1757(9-10):1366-70. (PMID: 16962064) Science. 2008 Apr 18;320(5874):362-5. (PMID: 18420932) Mol Biol Cell. 2008 Sep;19(9):3871-84. (PMID: 18614794) Nat Genet. 2008 Oct;40(10):1204-10. (PMID: 18758461) Nature. 2008 Dec 4;456(7222):605-10. (PMID: 19052620) Eukaryot Cell. 2009 Feb;8(2):161-9. (PMID: 19060182) |
معلومات مُعتمدة: | BB/M011801/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; MR/J006580/1 United Kingdom MRC_ Medical Research Council |
فهرسة مساهمة: | Keywords: S. cerevisiae; StART protein; VASt domains; cell biology; cholesterol; ergosterol; lipid traffic; membrane contact sites; polyenes |
المشرفين على المادة: | 0 (Carrier Proteins) 0 (Mitochondrial Proteins) 0 (Saccharomyces cerevisiae Proteins) 0 (Sterols) 0 (Ysp2 protein, S cerevisiae) |
تواريخ الأحداث: | Date Created: 20150523 Date Completed: 20160308 Latest Revision: 20210109 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC4463742 |
DOI: | 10.7554/eLife.07253 |
PMID: | 26001273 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2050-084X |
---|---|
DOI: | 10.7554/eLife.07253 |