دورية أكاديمية
Assessment of TREM2 rs75932628 association with amyotrophic lateral sclerosis in a Chinese population.
| العنوان: | Assessment of TREM2 rs75932628 association with amyotrophic lateral sclerosis in a Chinese population. |
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| المؤلفون: | Chen X; Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China., Chen Y; Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China., Wei Q; Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China., Guo X; Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China., Cao B; Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China., Ou R; Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China., Zhao B; Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China., Shang HF; Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address: hfshang2002@163.com. |
| المصدر: | Journal of the neurological sciences [J Neurol Sci] 2015 Aug 15; Vol. 355 (1-2), pp. 193-5. Date of Electronic Publication: 2015 May 16. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375403 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5883 (Electronic) Linking ISSN: 0022510X NLM ISO Abbreviation: J Neurol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier, <19 -> |
| مواضيع طبية MeSH: | Amyotrophic Lateral Sclerosis/*genetics , Genetic Predisposition to Disease/*genetics , Membrane Glycoproteins/*genetics , Polymorphism, Single Nucleotide/*genetics , Receptors, Immunologic/*genetics, Adult ; Aged ; Asian People/genetics ; Female ; Genetic Association Studies ; Genotype ; Humans ; Male ; Middle Aged |
| مستخلص: | Although, rs75932628 in triggering receptor expressed on myeloid cells 2 (TREM2) was shown to increase the risk for Alzheimer's disease, there is no agreement on the association between this variant and the risk for amyotrophic lateral sclerosis (ALS). We conducted a large-sample study to investigate if this variant is associated with ALS in a Chinese population. A total of 868 sporadic ALS (SALS) and 869 healthy controls were included. All cases were genotyped for the single nucleotide polymorphisms (SNP) using Sequenom iPLEX Assay technology. The rs75932628-T variant of the TREM2 gene was not identified in SALS patients and controls. It is unlikely to play a role in the pathogenesis of ALS in Chinese patients with SALS. (Copyright © 2015 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Alzheimer's disease; Amyotrophic lateral sclerosis; Genotyping; Single nucleotide polymorphisms; TREM2; rs75932628 |
| المشرفين على المادة: | 0 (Membrane Glycoproteins) 0 (Receptors, Immunologic) 0 (TREM2 protein, human) |
| تواريخ الأحداث: | Date Created: 20150601 Date Completed: 20160328 Latest Revision: 20221207 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jns.2015.05.010 |
| PMID: | 26026943 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1878-5883 |
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| DOI: | 10.1016/j.jns.2015.05.010 |