دورية أكاديمية
أعرض في EDS

The effect of neuronal conditional knock-out of peroxisome proliferator-activated receptors in the MPTP mouse model of Parkinson's disease.

التفاصيل البيبلوغرافية
العنوان: The effect of neuronal conditional knock-out of peroxisome proliferator-activated receptors in the MPTP mouse model of Parkinson's disease.
المؤلفون: Mounsey RB; School of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom., Martin HL; School of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom; Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom., Nelson MC; Gene Expression Laboratory, Salk Institute, La Jolla, CA, USA., Evans RM; Gene Expression Laboratory, Salk Institute, La Jolla, CA, USA., Teismann P; School of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom. Electronic address: p.teismann@abdn.ac.uk.
المصدر: Neuroscience [Neuroscience] 2015 Aug 06; Vol. 300, pp. 576-84. Date of Electronic Publication: 2015 May 29.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE
أسماء مطبوعة: Publication: [New York?] : Elsevier Science
Original Publication: Oxford, Elmsford, N. Y., Pergamon Press
مواضيع طبية MeSH: MPTP Poisoning/*metabolism , PPAR delta/*metabolism , PPAR gamma/*metabolism, 3,4-Dihydroxyphenylacetic Acid/metabolism ; Animals ; Brain/metabolism ; Brain/pathology ; Chromatography, High Pressure Liquid ; Dopamine/metabolism ; Dopaminergic Neurons/metabolism ; Dopaminergic Neurons/pathology ; Fluorescent Antibody Technique ; Immunohistochemistry ; MPTP Poisoning/pathology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Neuroglia/metabolism ; Neuroglia/pathology ; PPAR delta/genetics ; PPAR gamma/genetics ; Tyrosine 3-Monooxygenase/metabolism
مستخلص: Activation of peroxisome proliferator-activated receptors (PPARs), namely PPARγ and PPARδ, has been shown to provide neuroprotection in a number of neurodegenerative disorders, such as Alzheimer's and Parkinson's disease (PD). The observed neuroprotective effects in experimental models of PD have been linked to anti-oxidant and anti-inflammatory actions. This study aimed to analyze the full influence of these receptors in neuroprotection by generating a nerve cell-specific conditional knock-out of these receptors and subjecting these genetically modified mice to the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to model dopaminergic degeneration. Mice null for both receptors show the lowest levels of tyrosine hydroxylase (TH)-positive cell bodies following MPTP administration. Presence of one or both these receptors show a trend toward protection against this degeneration, as higher dopaminergic cell immunoreactivity and striatal monoamine levels are evident. These data supplement recent studies that have elected to use agonists of the receptors to regulate immune responses. The results place further importance on the activation of PPARs and the neuroprotective roles these have in inflammatory processes linked to neurodegenerative processes.
(Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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معلومات مُعتمدة: DK057978 United States DK NIDDK NIH HHS; United Kingdom BB_ Biotechnology and Biological Sciences Research Council; United States HHMI Howard Hughes Medical Institute; R37 DK057978 United States DK NIDDK NIH HHS; WT080782MF United Kingdom WT_ Wellcome Trust; United Kingdom WT_ Wellcome Trust; R01 DK057978 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: MPTP; Parkinson’s disease; neurodegeneration; peroxisome proliferator-activated receptor
المشرفين على المادة: 0 (PPAR delta)
0 (PPAR gamma)
102-32-9 (3,4-Dihydroxyphenylacetic Acid)
EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
VTD58H1Z2X (Dopamine)
تواريخ الأحداث: Date Created: 20150602 Date Completed: 20160329 Latest Revision: 20230712
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4512257
DOI: 10.1016/j.neuroscience.2015.05.048
PMID: 26028469
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-7544
DOI:10.1016/j.neuroscience.2015.05.048