دورية أكاديمية
[Pharmacokinetic evaluation of afobazole pharmaceutical composition with modified release].
| العنوان: | [Pharmacokinetic evaluation of afobazole pharmaceutical composition with modified release]. |
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| المؤلفون: | Bochkov PO, Litvin AA, Kolyvanov GB, Viglinskaya AO, Zherdev VP, Blynskaya EV, Alekseev KV |
| المصدر: | Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2015; Vol. 78 (3), pp. 27-9. |
| نوع المنشور: | Evaluation Study; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Izd-vo Meditsina Country of Publication: Russia (Federation) NLM ID: 9215981 Publication Model: Print Cited Medium: Print ISSN: 0869-2092 (Print) Linking ISSN: 08692092 NLM ISO Abbreviation: Eksp Klin Farmakol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva : Izd-vo Meditsina |
| مواضيع طبية MeSH: | Benzimidazoles/*pharmacokinetics , Benzimidazoles/*pharmacology , Morpholines/*pharmacokinetics , Morpholines/*pharmacology, Administration, Oral ; Animals ; Delayed-Action Preparations/pharmacokinetics ; Delayed-Action Preparations/pharmacology ; Male ; Rats |
| مستخلص: | The main pharmacokinetic parameters (AUC0-∞, Tmax, Cmax, Cl/F, t1/2 el, MRT, Cmax/AUC0-I, Vd/F) of afobazole base in a new pharmaceutical composition and afobazole dihydrochloride substance after single peroral administration have been determined in rats. The availability of afobazole base pharmaceutical composition relative to that of the substance amounted to 153.2%. |
| المشرفين على المادة: | 0 (2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole) 0 (Benzimidazoles) 0 (Delayed-Action Preparations) 0 (Morpholines) |
| تواريخ الأحداث: | Date Created: 20150604 Date Completed: 20150707 Latest Revision: 20191210 |
| رمز التحديث: | 20221213 |
| PMID: | 26036008 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0869-2092 |
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