دورية أكاديمية
أعرض في EDS

Microparticles Containing Curcumin Solid Dispersion: Stability, Bioavailability and Anti-Inflammatory Activity.

التفاصيل البيبلوغرافية
العنوان: Microparticles Containing Curcumin Solid Dispersion: Stability, Bioavailability and Anti-Inflammatory Activity.
المؤلفون: Teixeira CC; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Via do Café, s/n, Campus USP, Ribeirão Preto, 14040-903, Brazil., Mendonça LM; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Via do Café, s/n, Campus USP, Ribeirão Preto, 14040-903, Brazil., Bergamaschi MM; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Via do Café, s/n, Campus USP, Ribeirão Preto, 14040-903, Brazil., Queiroz RH; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Via do Café, s/n, Campus USP, Ribeirão Preto, 14040-903, Brazil., Souza GE; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Via do Café, s/n, Campus USP, Ribeirão Preto, 14040-903, Brazil., Antunes LM; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Via do Café, s/n, Campus USP, Ribeirão Preto, 14040-903, Brazil., Freitas LA; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Via do Café, s/n, Campus USP, Ribeirão Preto, 14040-903, Brazil. lapdfrei@usp.br.
المصدر: AAPS PharmSciTech [AAPS PharmSciTech] 2016 Apr; Vol. 17 (2), pp. 252-61. Date of Electronic Publication: 2015 Jun 04.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 100960111 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-9932 (Electronic) Linking ISSN: 15309932 NLM ISO Abbreviation: AAPS PharmSciTech Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Springer
Original Publication: Arlington, VA : American Association of Pharmaceutical Scientists, c2000-
مواضيع طبية MeSH: Drug Stability*, Anti-Inflammatory Agents/*chemistry , Anti-Inflammatory Agents/*pharmacokinetics , Curcumin/*chemistry , Curcumin/*pharmacokinetics, Animals ; Anti-Inflammatory Agents/pharmacology ; Biological Availability ; Chemistry, Pharmaceutical/methods ; Curcumin/pharmacology ; Fats/chemistry ; Fats/pharmacokinetics ; Fats/pharmacology ; Male ; Oils/chemistry ; Oils/pharmacokinetics ; Oils/pharmacology ; Rats ; Rats, Wistar ; Silicon Dioxide/chemistry ; Silicon Dioxide/pharmacokinetics ; Silicon Dioxide/pharmacology ; Solubility ; Technology, Pharmaceutical/methods ; X-Ray Diffraction/methods
مستخلص: This work aimed at improving the solubility of curcumin by the preparation of spray-dried ternary solid dispersions containing Gelucire®50/13-Aerosil® and quantifying the resulting in vivo oral bioavailability and anti-inflammatory activity. The solid dispersion containing 40% of curcumin was characterised by calorimetry, infrared spectroscopy and X-ray powder diffraction. The solubility and dissolution rate of curcumin in aqueous HCl or phosphate buffer improved up to 3600- and 7.3-fold, respectively. Accelerated stability test demonstrated that the solid dispersion was stable for 9 months. The pharmacokinetic study showed a 5.5-fold increase in curcumin in rat blood plasma when compared to unprocessed curcumin. The solid dispersion also provided enhanced anti-inflammatory activity in rat paw oedema. Finally, the solid dispersion proposed here is a promising way to enhance curcumin bioavailability at an industrial pharmaceutical perspective, since its preparation applies the spray drying, which is an easy to scale up technique. The findings herein stimulate further in vivo evaluations and clinical tests as a cancer and Alzheimer chemoprevention agent.
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فهرسة مساهمة: Keywords: bioavailability; blood level; dissolution; rat paw oedema; solubility; spray drying; thermal analysis; turmeric
المشرفين على المادة: 0 (Anti-Inflammatory Agents)
0 (Fats)
0 (Oils)
121548-05-8 (Gelucire 50-13)
7631-86-9 (Silicon Dioxide)
IT942ZTH98 (Curcumin)
تواريخ الأحداث: Date Created: 20150605 Date Completed: 20161216 Latest Revision: 20181113
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4984877
DOI: 10.1208/s12249-015-0337-6
PMID: 26040724
قاعدة البيانات: MEDLINE
الوصف
تدمد:1530-9932
DOI:10.1208/s12249-015-0337-6