دورية أكاديمية
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Assessment of TREM2 rs75932628 association with Parkinson's disease and multiple system atrophy in a Chinese population.

التفاصيل البيبلوغرافية
العنوان: Assessment of TREM2 rs75932628 association with Parkinson's disease and multiple system atrophy in a Chinese population.
المؤلفون: Chen Y; Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China., Chen X; Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China., Guo X; Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China., Song W; Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China., Cao B; Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China., Wei Q; Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China., Ou R; Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China., Zhao B; Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China., Shang HF; Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. hfshang@yahoo.com.
المصدر: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2015 Oct; Vol. 36 (10), pp. 1903-6. Date of Electronic Publication: 2015 Jun 10.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100959175 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1590-3478 (Electronic) Linking ISSN: 15901874 NLM ISO Abbreviation: Neurol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Milano, Italy : Springer-Verlag Italia, c2000-
مواضيع طبية MeSH: Genetic Predisposition to Disease/*genetics , Membrane Glycoproteins/*genetics , Multiple System Atrophy/*genetics , Parkinson Disease/*genetics , Polymorphism, Single Nucleotide/*genetics , Receptors, Immunologic/*genetics, Adult ; Aged ; Asian People/genetics ; Female ; Genetic Association Studies ; Genotype ; Humans ; Male ; Middle Aged
مستخلص: Although rs75932628 in triggering receptor expressed on myeloid cells 2 (TREM2) was shown to increase the risk for Alzheimer's disease, there is no agreement on the association between this variant and the risk for Parkinson's disease (PD). Considering the overlapping of clinical manifestation and pathologic characteristics of PD and multiple system atrophy (MSA), we conducted a large-sample study to investigate the associations between this variant and these two neurodegenerative diseases in a Chinese population. A total of 1216 PD, 406 MSA patients, and 869 healthy controls were included. All cases were genotyped for the Single Nucleotide Polymorphisms (SNP) using Sequenom iPLEX Assay technology. The rs75932628-T variant of the TREM2 gene was not identified in PD patients and controls. The genotype frequency of rs75932628-T SNP in MSA patients was 0.25% (1/406). However, no significant correlation was identified between this variant and the risk for MSA. TREM2 rs75932628 is unlikely to play a major role in the pathogenesis of these neurodegenerative diseases. Our findings argue against a generalized immune dysfunction triggered by the variant in the TREM2 gene.
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فهرسة مساهمة: Keywords: Multiple system atrophy; Parkinson’s disease; TREM2; rs75932628
المشرفين على المادة: 0 (Membrane Glycoproteins)
0 (Receptors, Immunologic)
0 (TREM2 protein, human)
تواريخ الأحداث: Date Created: 20150611 Date Completed: 20160629 Latest Revision: 20221207
رمز التحديث: 20221213
DOI: 10.1007/s10072-015-2279-x
PMID: 26058955
قاعدة البيانات: MEDLINE
الوصف
تدمد:1590-3478
DOI:10.1007/s10072-015-2279-x