دورية أكاديمية
Abnormal tuning of saccade-related cells in pontine reticular formation of strabismic monkeys.
| العنوان: | Abnormal tuning of saccade-related cells in pontine reticular formation of strabismic monkeys. |
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| المؤلفون: | Walton MM; Washington National Primate Research Center, University of Washington, Seattle, Washington; mark.walton@wanprc.org., Mustari MJ; Washington National Primate Research Center, University of Washington, Seattle, Washington; Department of Ophthalmology, University of Washington, Seattle, Washington; and Department of Biological Structure, University of Washington, Seattle, Washington. |
| المصدر: | Journal of neurophysiology [J Neurophysiol] 2015 Aug; Vol. 114 (2), pp. 857-68. Date of Electronic Publication: 2015 Jun 10. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 0375404 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1598 (Electronic) Linking ISSN: 00223077 NLM ISO Abbreviation: J Neurophysiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Bethesda Md : American Physiological Society Original Publication: Washington [etc.] |
| مواضيع طبية MeSH: | Neurons/*physiology , Pontine Tegmentum/*physiopathology , Saccades/*physiology , Strabismus/*physiopathology, Action Potentials ; Animals ; Disease Models, Animal ; Electric Stimulation ; Female ; Functional Laterality ; Lenses ; Macaca mulatta ; Microelectrodes ; Motor Activity/physiology ; Neural Pathways/physiopathology ; Photic Stimulation ; Regression Analysis ; Visual Perception/physiology |
| مستخلص: | Strabismus is a common disorder, characterized by a chronic misalignment of the eyes and numerous visual and oculomotor abnormalities. For example, saccades are often highly disconjugate. For humans with pattern strabismus, the horizontal and vertical disconjugacies vary with eye position. In monkeys, manipulations that disturb binocular vision during the first several weeks of life result in a chronic strabismus with characteristics that closely match those in human patients. Early onset strabismus is associated with altered binocular sensitivity of neurons in visual cortex. Here we test the hypothesis that brain stem circuits specific to saccadic eye movements are abnormal. We targeted the pontine paramedian reticular formation, a structure that directly projects to the ipsilateral abducens nucleus. In normal animals, neurons in this structure are characterized by a high-frequency burst of spikes associated with ipsiversive saccades. We recorded single-unit activity from 84 neurons from four monkeys (two normal, one exotrope, and one esotrope), while they made saccades to a visual target on a tangent screen. All 24 neurons recorded from the normal animals had preferred directions within 30° of pure horizontal. For the strabismic animals, the distribution of preferred directions was normal on one side of the brain, but highly variable on the other. In fact, 12/60 neurons recorded from the strabismic animals preferred vertical saccades. Many also had unusually weak or strong bursts. These data suggest that the loss of corresponding binocular vision during infancy impairs the development of normal tuning characteristics for saccade-related neurons in brain stem. (Copyright © 2015 the American Physiological Society.) |
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| معلومات مُعتمدة: | P51OD010425 United States OD NIH HHS; U54 HD083091 United States HD NICHD NIH HHS; P51 OD010425 United States OD NIH HHS; R01 EY024248 United States EY NEI NIH HHS; P30 EY001730 United States EY NEI NIH HHS; EY-024848 United States EY NEI NIH HHS; EY-06069 United States EY NEI NIH HHS; R01 EY006069 United States EY NEI NIH HHS |
| فهرسة مساهمة: | Keywords: PPRF; esotropia; exotropia; monkey; strabismus |
| تواريخ الأحداث: | Date Created: 20150612 Date Completed: 20160425 Latest Revision: 20240522 |
| رمز التحديث: | 20240522 |
| مُعرف محوري في PubMed: | PMC4533063 |
| DOI: | 10.1152/jn.00238.2015 |
| PMID: | 26063778 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1522-1598 |
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| DOI: | 10.1152/jn.00238.2015 |