دورية أكاديمية
Resveratrol improves hepatic insulin signaling and reduces the inflammatory response in streptozotocin-induced diabetes.
| العنوان: | Resveratrol improves hepatic insulin signaling and reduces the inflammatory response in streptozotocin-induced diabetes. |
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| المؤلفون: | Sadi G; Department of Biology, K.Ö.Science Faculty, Karamanoglu Mehmetbey University, Karaman, Turkey. Electronic address: sadi@kmu.edu.tr., Pektaş MB; Department of Medical Pharmacology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey. Electronic address: mbpektas@hotmail.com., Koca HB; Department of Medical Biochemistry, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey. Electronic address: bugrakoca@yahoo.com., Tosun M; Department of Histology Embryology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey. Electronic address: drmtosun@yahoo.com., Koca T; Department of Medical Laboratory, Ataturk Vocational School of Health Services, Afyon Kocatepe University, Afyonkarahisar, Turkey. Electronic address: tulay_akan@yahoo.com. |
| المصدر: | Gene [Gene] 2015 Oct 10; Vol. 570 (2), pp. 213-20. Date of Electronic Publication: 2015 Jun 10. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 7706761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0038 (Electronic) Linking ISSN: 03781119 NLM ISO Abbreviation: Gene Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland, 1976- |
| مواضيع طبية MeSH: | Diabetes Mellitus, Experimental/*metabolism , Inflammation/*prevention & control , Insulin/*metabolism , Liver/*drug effects , Signal Transduction/*drug effects , Stilbenes/*pharmacology, Animals ; Liver/metabolism ; Male ; Rats ; Rats, Wistar ; Resveratrol ; Streptozocin |
| مستخلص: | Diabetes mellitus is a heterogeneous metabolic disorder essentially characterized by deficiency of insulin secretion, insulin receptor or post-receptor events. This study aims to investigate the effects of resveratrol administration on the metabolic characteristics, hepatic functions, histopathological features and insulin signaling pathway components in streptozotocin induced diabetes. Male Wistar rats were randomly divided into four groups: (1) control/vehicle; (2) control/20mg/kg resveratrol; (3) diabetic/vehicle; and (4) diabetic/20mg/kg resveratrol. Histopathological examinations were carried out to reveal hepatic tissue damage and inflammation. In addition to hepatic glucose, lipid, insulin, ALT, AST, resistin and XOD contents, gene and protein expressions of insulin signaling pathway components such as insulin Rβ, IRS-1, IRS-2, eNOS, PI3K, Akt, and FOXO3a were analyzed by qRT-PCR and Western blot. The rats in the diabetes group had significantly lower terminal body weight and hepatic insulin level, but significantly higher hepatic glucose, total cholesterol, triglyceride and resistin concentrations. Diabetes triggered the inflammatory process in the liver tissues that was evidenced by histopathological deformations and increase in the hepatic ALT and AST levels. Hepatic inflammation was considerably associated with insulin signaling pathway ever since a significant down-regulation of insulin signaling components; IRS-1, IRS-2, PI3K, Akt and mTOR have been identified in the diabetic group. To some extent, resveratrol treatment reversed the diabetes-induced changes in the liver tissues. Taken together, resveratrol partly improved hepatic dysfunction induced by diabetes. This may be due to the healing activity of resveratrol on insulin signaling pathway, resistin levels and hepatic glucose-lipid contents. (Copyright © 2015 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Diabetes; Insulin signaling; Liver; PI3K/Akt; Resistin; Resveratrol |
| المشرفين على المادة: | 0 (Insulin) 0 (Stilbenes) 5W494URQ81 (Streptozocin) Q369O8926L (Resveratrol) |
| تواريخ الأحداث: | Date Created: 20150614 Date Completed: 20151117 Latest Revision: 20220317 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.gene.2015.06.019 |
| PMID: | 26071184 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0038 |
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| DOI: | 10.1016/j.gene.2015.06.019 |