دورية أكاديمية
Morphometric Examination of Mitochondrial Ultrastructure in Aging Cardiomyocytes.
| العنوان: | Morphometric Examination of Mitochondrial Ultrastructure in Aging Cardiomyocytes. |
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| المؤلفون: | El'darov ChM; Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology, Moscow, 119991, Russia. fhb@belozersky.msu.ru., Vays VB, Vangeli IM, Kolosova NG, Bakeeva LE |
| المصدر: | Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2015 May; Vol. 80 (5), pp. 604-9. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: MAIK Nauka/Interperiodica Country of Publication: United States NLM ID: 0376536 Publication Model: Print Cited Medium: Internet ISSN: 1608-3040 (Electronic) Linking ISSN: 00062979 NLM ISO Abbreviation: Biochemistry (Mosc) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2007->: Moscow : MAIK Nauka/Interperiodica Original Publication: New York, Consultants Bureau [etc.] |
| مواضيع طبية MeSH: | Aging/*pathology , Mitochondria, Heart/*ultrastructure , Mitochondrial Membranes/*ultrastructure , Myocytes, Cardiac/*ultrastructure, Aging/metabolism ; Animals ; Cellular Senescence ; Male ; Mitochondria, Heart/metabolism ; Mitochondrial Membranes/metabolism ; Myocytes, Cardiac/metabolism ; Rats ; Rats, Wistar |
| مستخلص: | Mitochondrial ultrastructure in cardiomyocytes from 3- and 24-month-old Wistar and OXYS rats was investigated using a new approach designed for morphometric analysis. The data fully confirm the electron microscopy data: the area of the inner mitochondrial membrane per unit volume of mitochondria was significantly decreased with age, as found on heart muscle section. In 3-month-old Wistar rats from the control group, this parameter was 41.3 ± 1.52 µm(2)/µm(3), whereas in OXYS rats it was decreased to 30.57 ± 1.74 µm(2)/µm(3). With age, an area of the inner mitochondrial membrane per unit volume of mitochondria declined in both rat strains: Wistar - from 41.3 ± 1.52 to 21.47 ± 1.22 µm(2)/µm(3), OXYS - from 30.57 ± 1.74 to 16.3 ± 0.89 µm(2)/µm(3). A new method that we designed and used for morphometric analysis notably simplifies the process of morphometric measurements and opens up good opportunities for its further optimization using image recognition technology. |
| تواريخ الأحداث: | Date Created: 20150615 Date Completed: 20160310 Latest Revision: 20171116 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1134/S0006297915050132 |
| PMID: | 26071780 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1608-3040 |
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| DOI: | 10.1134/S0006297915050132 |