دورية أكاديمية
أعرض في EDS

Ameliorative Effect of Vicenin-2 and Scolymoside on TGFBIp-Induced Septic Responses.

التفاصيل البيبلوغرافية
العنوان: Ameliorative Effect of Vicenin-2 and Scolymoside on TGFBIp-Induced Septic Responses.
المؤلفون: Lee W; College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Kyungpook National University, 80 Dahak-ro, Buk-gu, Daegu, 702-701, Republic of Korea.; Department of Biochemistry and Cell Biology, BK21 Plus KNU Biomedical Convergence Program, School of Medicine, Kyungpook National University, Daegu, 702-701, Republic of Korea., Ku SK; Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan, 712-715, Republic of Korea., Bae JS; College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Kyungpook National University, 80 Dahak-ro, Buk-gu, Daegu, 702-701, Republic of Korea. baejs@knu.ac.kr.
المصدر: Inflammation [Inflammation] 2015 Dec; Vol. 38 (6), pp. 2166-77.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 7600105 Publication Model: Print Cited Medium: Internet ISSN: 1573-2576 (Electronic) Linking ISSN: 03603997 NLM ISO Abbreviation: Inflammation Subsets: MEDLINE
أسماء مطبوعة: Publication: 1999- : New York, NY : Kluwer Academic/Plenum Publishers
Original Publication: New York, Plenum Press.
مواضيع طبية MeSH: Cyclopia Plant*/chemistry, Anti-Inflammatory Agents/*pharmacology , Apigenin/*pharmacology , Extracellular Matrix Proteins/*metabolism , Glucosides/*pharmacology , Human Umbilical Vein Endothelial Cells/*metabolism , Luteolin/*pharmacology , Plant Extracts/*pharmacology , Sepsis/*prevention & control , Transforming Growth Factor beta/*metabolism, Animals ; Anti-Inflammatory Agents/isolation & purification ; Apigenin/isolation & purification ; Capillary Permeability/drug effects ; Cell Adhesion/drug effects ; Cell Adhesion Molecules/metabolism ; Cells, Cultured ; Chemotaxis, Leukocyte/drug effects ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Enzyme Activation ; Extracellular Matrix Proteins/immunology ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Glucosides/isolation & purification ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/immunology ; Inflammation Mediators/metabolism ; Luteolin/isolation & purification ; Male ; Mice, Inbred C57BL ; Neutrophils/drug effects ; Neutrophils/immunology ; Neutrophils/metabolism ; Phytotherapy ; Plant Extracts/isolation & purification ; Plants, Medicinal ; Pulmonary Edema/immunology ; Pulmonary Edema/prevention & control ; Sepsis/immunology ; Sepsis/metabolism ; Sepsis/microbiology ; Time Factors ; Transforming Growth Factor beta/immunology
مستخلص: Transforming growth factor β-induced protein (TGFBIp) is an extracellular matrix protein whose expression in several cell types is greatly increased by TGF-β. TGFBIp is released by the human umbilical vein endothelial cells (HUVECs) and functions as a mediator of experimental sepsis. Cyclopia subternata is a medicinal plant commonly used in traditional medicine to relieve pain in biological processes. In this study, we investigated the antiseptic effects and underlying mechanisms of vicenin-2 and scolymoside, two active compounds in C. subternata against TGFBIp-mediated septic responses in HUVECs and mice. The anti-inflammatory activities of vicenin-2 or scolymoside were determined by measuring permeability, human neutrophils adhesion and migration, and activation of pro-inflammatory proteins in TGFBIp-activated HUVECs and mice. According to the results, vicenin-2 or scolymoside effectively inhibited lipopolysaccharide-induced release of TGFBIp and suppressed TGFBIp-mediated septic responses, such as hyperpermeability, adhesion and migration of leukocytes, and expression of cell adhesion molecules. In addition, vicenin-2 or scolymoside suppressed the production of tumor necrosis factor-α and interleukin 6 and activation of nuclear factor-κB and extracellular regulated kinases 1/2 by TGFBIp. Vicenin-2 or scolymoside reduced cecal ligation and puncture (CLP)-induced septic mortality and pulmonary injury. Collectively, these results indicate that vicenin-2 and scolymoside could be a potential therapeutic agent for treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway.
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فهرسة مساهمة: Keywords: HUVEC; TGFBIp; inflammation; scolymoside; sepsis; vicenin-2
المشرفين على المادة: 0 (Anti-Inflammatory Agents)
0 (Cell Adhesion Molecules)
0 (Extracellular Matrix Proteins)
0 (Glucosides)
0 (Inflammation Mediators)
0 (Plant Extracts)
0 (Transforming Growth Factor beta)
0 (apigenin-6,8-di-C-glycopyranoside)
0 (scolymoside)
148710-76-3 (betaIG-H3 protein)
7V515PI7F6 (Apigenin)
EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
KUX1ZNC9J2 (Luteolin)
تواريخ الأحداث: Date Created: 20150619 Date Completed: 20160822 Latest Revision: 20181113
رمز التحديث: 20240628
DOI: 10.1007/s10753-015-0199-9
PMID: 26084452
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-2576
DOI:10.1007/s10753-015-0199-9