دورية أكاديمية
أعرض في EDS

WNT/β-Catenin Signaling Is Required for Integration of CD24+ Renal Progenitor Cells into Glycerol-Damaged Adult Renal Tubules.

التفاصيل البيبلوغرافية
العنوان: WNT/β-Catenin Signaling Is Required for Integration of CD24+ Renal Progenitor Cells into Glycerol-Damaged Adult Renal Tubules.
المؤلفون: Zhang Z; Department of Paediatrics, Montreal Children's Hospital Research Institute, McGill University, Montreal, QC, Canada., Iglesias DM; Department of Paediatrics, Montreal Children's Hospital Research Institute, McGill University, Montreal, QC, Canada., Corsini R; Department of Paediatrics, Montreal Children's Hospital Research Institute, McGill University, Montreal, QC, Canada., Chu L; Department of Paediatrics, Montreal Children's Hospital Research Institute, McGill University, Montreal, QC, Canada., Goodyer P; Department of Paediatrics, Montreal Children's Hospital Research Institute, McGill University, Montreal, QC, Canada ; Department of Human Genetics, Montreal Children's Hospital Research Institute, McGill University, Montreal, QC, Canada.
المصدر: Stem cells international [Stem Cells Int] 2015; Vol. 2015, pp. 391043. Date of Electronic Publication: 2015 May 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Country of Publication: United States NLM ID: 101535822 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1687-966X (Print) NLM ISO Abbreviation: Stem Cells Int Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2011- : New York : Hindawi
Original Publication: London, England ; New York, NY : SAGE-Hindawi Access to Research
مستخلص: During development, nephron progenitor cells (NPC) are induced to differentiate by WNT9b signals from the ureteric bud. Although nephrogenesis ends in the perinatal period, acute kidney injury (AKI) elicits repopulation of damaged nephrons. Interestingly, embryonic NPC infused into adult mice with AKI are incorporated into regenerating tubules. Since WNT/β-catenin signaling is crucial for primary nephrogenesis, we reasoned that it might also be needed for the endogenous repair mechanism and for integration of exogenous NPC. When we examined glycerol-induced AKI in adult mice bearing a β-catenin/TCF reporter transgene, endogenous tubular cells reexpressed the NPC marker, CD24, and showed widespread β-catenin/TCF signaling. We isolated CD24+ cells from E15 kidneys of mice with the canonical WNT signaling reporter. 40% of cells responded to WNT3a in vitro and when infused into glycerol-injured adult, the cells exhibited β-catenin/TCF reporter activity when integrated into damaged tubules. When embryonic CD24+ cells were treated with a β-catenin/TCF pathway inhibitor (IWR-1) prior to infusion into glycerol-injured mice, tubular integration of cells was sharply reduced. Thus, the endogenous canonical β-catenin/TCF pathway is reactivated during recovery from AKI and is required for integration of exogenous embryonic renal progenitor cells into damaged tubules. These events appear to recapitulate the WNT-dependent inductive process which drives primary nephrogenesis.
References: Kidney Int. 2007 Aug;72(4):430-41. (PMID: 17507906)
Nature. 1994 Dec 15;372(6507):679-83. (PMID: 7990960)
Dev Genet. 1999;24(3-4):241-51. (PMID: 10322632)
Dev Biol. 2004 Jul 1;271(1):98-108. (PMID: 15196953)
Stem Cells. 2009 Sep;27(9):2247-53. (PMID: 19739254)
J Am Soc Nephrol. 2007 Dec;18(12 ):3128-38. (PMID: 17978305)
Proc Natl Acad Sci U S A. 2011 May 31;108(22):9226-31. (PMID: 21576461)
PLoS One. 2012;7(8):e42840. (PMID: 22912749)
Stem Cells. 2012 Aug;30(8):1714-25. (PMID: 22628275)
J Am Soc Nephrol. 2004 Sep;15(9):2344-57. (PMID: 15339983)
Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4640-5. (PMID: 23487745)
Am J Pathol. 2010 Oct;177(4):2011-21. (PMID: 20724594)
Dev Biol. 2008 Dec 1;324(1):88-98. (PMID: 18835385)
Hum Mol Genet. 2011 Nov 1;20(21):4167-74. (PMID: 21821672)
J Am Soc Nephrol. 2006 Sep;17 (9):2443-56. (PMID: 16885410)
Dev Dyn. 2010 Jul;239(7):2014-23. (PMID: 20549720)
J Am Soc Nephrol. 2008 Apr;19(4):667-71. (PMID: 18287559)
Blood. 2009 Sep 17;114(12):2542-52. (PMID: 19506297)
Exp Cell Res. 2004 Aug 15;298(2):369-87. (PMID: 15265686)
Dev Cell. 2005 Aug;9(2):283-92. (PMID: 16054034)
Nature. 2009 Oct 1;461(7264):614-20. (PMID: 19759537)
Fibrogenesis Tissue Repair. 2009 Jun 26;2(1):3. (PMID: 19558670)
Am J Physiol Renal Physiol. 2007 Aug;293(2):F494-500. (PMID: 17494089)
تواريخ الأحداث: Date Created: 20150620 Date Completed: 20150619 Latest Revision: 20220309
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4452100
DOI: 10.1155/2015/391043
PMID: 26089915
قاعدة البيانات: MEDLINE
الوصف
تدمد:1687-966X
DOI:10.1155/2015/391043