دورية أكاديمية
أعرض في EDS

The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer's disease.

التفاصيل البيبلوغرافية
العنوان: The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer's disease.
المؤلفون: Mesquita SD; Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimaraes, Portugal., Ferreira AC; Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimaraes, Portugal., Gao F; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine - University of California, Los Angeles, CA, USA., Coppola G; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine - University of California, Los Angeles, CA, USA., Geschwind DH; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine - University of California, Los Angeles, CA, USA., Sousa JC; Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimaraes, Portugal., Correia-Neves M; Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimaraes, Portugal., Sousa N; Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimaraes, Portugal., Palha JA; Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimaraes, Portugal., Marques F; Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimaraes, Portugal. Electronic address: fmarques@ecsaude.uminho.pt.
المصدر: Brain, behavior, and immunity [Brain Behav Immun] 2015 Oct; Vol. 49, pp. 280-92. Date of Electronic Publication: 2015 Jun 16.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE
أسماء مطبوعة: Publication: <2000- > : Amsterdam : Elsevier
Original Publication: San Diego : Academic Press, [c1987-
مواضيع طبية MeSH: Transcriptome*, Alzheimer Disease/*genetics , Choroid Plexus/*metabolism , Interferon Type I/*genetics , Interferon-gamma/*genetics, Aging/genetics ; Aging/psychology ; Alzheimer Disease/psychology ; Amyloid beta-Peptides/metabolism ; Animals ; Astrocytes/metabolism ; Disease Models, Animal ; Interferon Type I/cerebrospinal fluid ; Interferon-gamma/cerebrospinal fluid ; Male ; Maze Learning/physiology ; Mice ; Mice, Inbred C57BL ; Neurons/metabolism
مستخلص: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a marked decline in cognition and memory function. Increasing evidence highlights the essential role of neuroinflammatory and immune-related molecules, including those produced at the brain barriers, on brain immune surveillance, cellular dysfunction and amyloid beta (Aβ) pathology in AD. Therefore, understanding the response at the brain barriers may unravel novel pathways of relevance for the pathophysiology of AD. Herein, we focused on the study of the choroid plexus (CP), which constitutes the blood-cerebrospinal fluid barrier, in aging and in AD. Specifically, we used the PDGFB-APPSwInd (J20) transgenic mouse model of AD, which presents early memory decline and progressive Aβ accumulation, and littermate age-matched wild-type (WT) mice, to characterize the CP transcriptome at 3, 5-6 and 11-12months of age. The most striking observation was that the CP of J20 mice displayed an overall overexpression of type I interferon (IFN) response genes at all ages. Moreover, J20 mice presented a high expression of type II IFN genes in the CP at 3months, which became lower than WT at 5-6 and 11-12months. Importantly, along with a marked memory impairment and increased glial activation, J20 mice also presented a similar overexpression of type I IFN genes in the dorsal hippocampus at 3months. Altogether, these findings provide new insights on a possible interplay between type I and II IFN responses in AD and point to IFNs as targets for modulation in cognitive decline.
(Copyright © 2015 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Aging; Alzheimer’s disease; Cerebrospinal fluid; Choroid plexus; Glial cells; Hippocampus; Interferons; Memory; Neuroinflammation; Transcriptome
سلسلة جزيئية: GEO GSE66598
المشرفين على المادة: 0 (Amyloid beta-Peptides)
0 (Interferon Type I)
82115-62-6 (Interferon-gamma)
تواريخ الأحداث: Date Created: 20150621 Date Completed: 20160607 Latest Revision: 20150910
رمز التحديث: 20231215
DOI: 10.1016/j.bbi.2015.06.008
PMID: 26092102
قاعدة البيانات: MEDLINE
الوصف
تدمد:1090-2139
DOI:10.1016/j.bbi.2015.06.008