دورية أكاديمية
أعرض في EDS

A Severe Accident Caused by an Ocellate River Stingray (Potamotrygon motoro) in Central Brazil: How Well Do We Really Understand Stingray Venom Chemistry, Envenomation, and Therapeutics?

التفاصيل البيبلوغرافية
العنوان: A Severe Accident Caused by an Ocellate River Stingray (Potamotrygon motoro) in Central Brazil: How Well Do We Really Understand Stingray Venom Chemistry, Envenomation, and Therapeutics?
المؤلفون: da Silva NJ Jr; Programa de Pós-Graduação em Ciências Ambientais e Saúde, Pontifícia Universidade Católica de Goiás, Rua 232 nº128 3º andar-Área V. Setor Universitário, CEP 74605-140 Goiânia, Goiás, Brazil. raimundo58@gmail.com.; Departamento de Medicina, Pontifícia Universidade Católica de Goiás, Avenida Universitária, 1069-Setor Universitário, CEP 74605-010 Goiânia, Goiás, Brazil. raimundo58@gmail.com., Ferreira KR; Faculdade de Ciências Médicas do Instituto de Pesquisa e Ensino Médico - IPEMED, Rua Dr. Nogueira Martins nº 706, Saúde, CEP 04143-020 São Paulo, São Paulo, Brazil. kalley.ferreira@me.com., Pinto RN; Departamento de Medicina, Pontifícia Universidade Católica de Goiás, Avenida Universitária, 1069-Setor Universitário, CEP 74605-010 Goiânia, Goiás, Brazil. raimundo58@gmail.com.; Hospital de Doenças Tropicais Dr. Anuar Auad. Rua SC-1 nº 299, Parque Santa Cruz, CEP 74860-270 Goiânia, Goiás, Brazil. raimundo58@gmail.com., Aird SD; Evolution and Ecology Unit, Communications and Public Relations Division, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna-son, Kunigami-gun, Okinawa 904-0495, Japan. steven.aird@oist.jp.
المصدر: Toxins [Toxins (Basel)] 2015 Jun 18; Vol. 7 (6), pp. 2272-88. Date of Electronic Publication: 2015 Jun 18.
نوع المنشور: Case Reports; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101530765 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6651 (Electronic) Linking ISSN: 20726651 NLM ISO Abbreviation: Toxins (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مواضيع طبية MeSH: Bites and Stings*/therapy , Skates, Fish*, Fish Venoms/*toxicity, Accidents ; Adult ; Analgesics/therapeutic use ; Animals ; Anti-Bacterial Agents/therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Brazil ; Debridement ; Humans ; Male
مستخلص: Freshwater stingrays cause many serious human injuries, but identification of the offending species is uncommon. The present case involved a large freshwater stingray, Potamotrygon motoro (Chondrichthyes: Potamotrygonidae), in the Araguaia River in Tocantins, Brazil. Appropriate first aid was administered within ~15 min, except that an ice pack was applied. Analgesics provided no pain relief, although hot compresses did. Ciprofloxacin therapy commenced after ~18 h and continued seven days. Then antibiotic was suspended; however, after two more days and additional tests, cephalosporin therapy was initiated, and proved successful. Pain worsened despite increasingly powerful analgesics, until debridement of the wound was performed after one month. The wound finally closed ~70 days after the accident, but the patient continued to have problems wearing shoes even eight months later. Chemistry and pharmacology of Potamotrygon venom and mucus, and clinical management of freshwater stingray envenomations are reviewed in light of the present case. Bacterial infections of stingray puncture wounds may account for more long-term morbidity than stingray venom. Simultaneous prophylactic use of multiple antibiotics is recommended for all but the most superficial stingray wounds. Distinguishing relative contributions of venom, mucus, and bacteria will require careful genomic and transcriptomic investigations of stingray tissues and contaminating bacteria.
References: Wei Sheng Wu Xue Bao. 2014 Jan 4;54(1):80-8. (PMID: 24783857)
Immunol Ser. 1989;46:477-507. (PMID: 2488867)
Toxicon. 2012 Oct;60(5):821-9. (PMID: 22683678)
Scand J Infect Dis. 1998;30(2):192-3. (PMID: 9730311)
Microbiol Immunol. 2012 Feb;56(2):123-7. (PMID: 22188523)
Biomed Res Int. 2015;2015:168292. (PMID: 25756041)
Curr Microbiol. 1997 Jan;34(1):49-54. (PMID: 8939802)
Toxicon. 2008 May;51(6):1060-7. (PMID: 18346772)
Ann Pharmacother. 2001 Dec;35(12):1540-7. (PMID: 11793615)
J Infect. 2006 Sep;53(3):e161-3. (PMID: 16375973)
Toxicon. 2006 Apr;47(5):575-83. (PMID: 16564065)
Cornea. 2015 Jun;34(6):698-703. (PMID: 25811722)
Clin Infect Dis. 2006 Nov 15;43(10):1309-17. (PMID: 17051499)
Maedica (Buchar). 2014 Jun;9(2):162-7. (PMID: 25705272)
Ann Intensive Care. 2011 Nov 23;1:47. (PMID: 22112929)
Toxicon. 2011 Feb;57(2):297-303. (PMID: 21163287)
J Clin Microbiol. 1984 Nov;20(5):1020-1. (PMID: 6096395)
J Med Microbiol. 1990 Mar;31(3):169-74. (PMID: 2156075)
Toxicon. 2015 Apr;97:32-5. (PMID: 25576234)
Heart Lung. 2000 Jul-Aug;29(4):306-8. (PMID: 10900069)
Toxicon. 2006 Jan;47(1):32-4. (PMID: 16303158)
J Med Vet Mycol. 1990;28(3):209-13. (PMID: 2213436)
Rev Infect Dis. 1979 Mar-Apr;1(2):254-62. (PMID: 232935)
J Accid Emerg Med. 1996 May;13(3):224-5. (PMID: 8733672)
Eur J Clin Invest. 1998 Jul;28(7):528-32. (PMID: 9726031)
J Gen Microbiol. 1983 Apr;129(4):1141-7. (PMID: 6310026)
J Travel Med. 2008 Mar-Apr;15(2):102-9. (PMID: 18346243)
Med Res Rev. 1999 Nov;19(6):497-520. (PMID: 10557367)
Toxicon. 2007 Oct;50(5):688-97. (PMID: 17659760)
Toxicon. 2014 Dec 15;92:97-101. (PMID: 25449099)
J Venom Anim Toxins Incl Trop Dis. 2013 Jul 29;19(1):16. (PMID: 23895313)
Rev Soc Bras Med Trop. 2010 Jan-Feb;43(1):82-8. (PMID: 20305975)
J Proteomics. 2014 Sep 23;109:188-98. (PMID: 24946716)
Clin Experiment Ophthalmol. 2007 Jan-Feb;35(1):102-4. (PMID: 17300586)
Toxicon. 2007 Oct;50(5):676-87. (PMID: 17669455)
Int Immunopharmacol. 2011 Sep;11(9):1368-77. (PMID: 21481330)
Can J Neurol Sci. 2013 Jan;40(1):127-8. (PMID: 23427360)
Adv Exp Med Biol. 1997;418:589-92. (PMID: 9331720)
Braz J Biol. 2010 Feb;70(1):155-62. (PMID: 20231973)
Annu Rev Microbiol. 1998;52:333-60. (PMID: 9891801)
Zootaxa. 2014;3765:249-68. (PMID: 24870898)
J Clin Microbiol. 2013 Apr;51(4):1324-6. (PMID: 23363826)
Toxicon. 2011 Aug;58(2):147-53. (PMID: 21635911)
Proc Soc Exp Biol Med. 1950 Jul;74(3):555-8. (PMID: 15440885)
Infect Immun. 1973 Feb;7(2):212-7. (PMID: 4348965)
N Engl J Med. 2000 Mar 16;342(11):824. (PMID: 10722346)
Matrix Suppl. 1992;1:127-33. (PMID: 1480012)
Toxicon. 2004 Mar 1;43(3):287-94. (PMID: 15033327)
J Bacteriol. 1980 May;142(2):447-54. (PMID: 6247322)
Science. 2010 Nov 12;330(6006):927-31. (PMID: 21071659)
Biochem J. 1992 Feb 1;281 ( Pt 3):703-8. (PMID: 1311172)
Microb Drug Resist. 2013 Dec;19(6):421-7. (PMID: 23789809)
J Clin Microbiol. 1998 Nov;36(11):3188-92. (PMID: 9774563)
J Emerg Med. 2007 Jul;33(1):33-7. (PMID: 17630073)
Peptides. 2009 Dec;30(12):2191-9. (PMID: 19682520)
Water Res. 2011 Nov 1;45(17):5599-611. (PMID: 21907383)
Front Microbiol. 2013 Nov 18;4:339. (PMID: 24302921)
Indian J Pathol Microbiol. 2004 Jan;47(1):82-4. (PMID: 15471144)
Am J Med Sci. 1958 May;235(5):566-84 passim. (PMID: 13533419)
South Med J. 1957 Apr;50(4):533-5. (PMID: 13421937)
Peptides. 2006 Dec;27(12):3039-46. (PMID: 17056153)
Wilderness Environ Med. 1997 Feb;8(1):24-8. (PMID: 11990133)
Trans N Y Acad Sci. 1972 Dec;34(8):677-86. (PMID: 4509224)
فهرسة مساهمة: Keywords: Potamotrygon motoro; antibiotics; pharmacology; stingray envenomation; treatment; venom chemistry
المشرفين على المادة: 0 (Analgesics)
0 (Anti-Bacterial Agents)
0 (Anti-Inflammatory Agents, Non-Steroidal)
0 (Fish Venoms)
تواريخ الأحداث: Date Created: 20150623 Date Completed: 20160331 Latest Revision: 20191210
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4488702
DOI: 10.3390/toxins7062272
PMID: 26094699
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6651
DOI:10.3390/toxins7062272